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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Apoptosis related genes mediated molecular subtypes depict the hallmarks of the tumor microenvironment and guide immunotherapy in bladder cancer

Fig. 3

The molecular subtypes categorization of BLCA base on 4 ARGs. A Kaplan–Meier curve showed a significant difference between the two ARGs clusters. B UMAP analysis for the transcriptome profiles of ARGs.cluster.A and ARGs.cluster.B, showing a remarkable difference on transcriptome between different group. C GO enrichment analysis, D KEGG enrichment analysis for the different expression that were correlated with OS genes. E The correlation of tumor microenvironment condition and ARGs.cluster. F The abundance of each TME infiltrating cell in two ARGs.clusters. The upper and lower ends of the boxes represented the interquartile range of values. The lines in the boxes represented median value, and black dots showed outliers. G–J The ESTIMATE score, stromal score, immune score, and tumor immunity levels in the ARGs.cluster.A and ARGs.cluster.B groups by using ESTIMATE algorithm. K–M The PD-1, PD-L1 and CATA4 levels in the ARGs.cluster.A and ARGs.cluster.B groups. (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001)

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BMC Medical Genomics

ISSN: 1755-8794

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