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  1. Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide. At present no reliable biomarkers are available to guide the management of this condition. Microarray technology may allow...

    Authors: Austin Tanney, Gavin R Oliver, Vadim Farztdinov, Richard D Kennedy, Jude M Mulligan, Ciaran E Fulton, Susan M Farragher, John K Field, Patrick G Johnston, D Paul Harkin, Vitali Proutski and Karl A Mulligan

    Citation: BMC Medical Genomics 2008 1:20

    Content type: Research article

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  2. The major histocompatibility complex (MHC) is essential for human immunity and is highly associated with common diseases, including cancer. While the genetics of the MHC has been studied intensively for many d...

    Authors: Eleni M Tomazou, Vardhman K Rakyan, Gregory Lefebvre, Robert Andrews, Peter Ellis, David K Jackson, Cordelia Langford, Matthew D Francis, Liselotte Bäckdahl, Marcos Miretti, Penny Coggill, Diego Ottaviani, Denise Sheer, Adele Murrell and Stephan Beck

    Citation: BMC Medical Genomics 2008 1:19

    Content type: Research article

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  3. Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects ~8 million annually culminating in ~2 million deaths. Moreover, about one third of the population is latently infected, 10% of which ...

    Authors: Anat Zvi, Naomi Ariel, John Fulkerson, Jerald C Sadoff and Avigdor Shafferman

    Citation: BMC Medical Genomics 2008 1:18

    Content type: Research article

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  4. The aberrant transcription in cancer of genes normally associated with embryonic tissue differentiation at various organ sites may be a hallmark of tumour progression. For example, neuroendocrine differentiati...

    Authors: Maria Vias, Charlie E Massie, Philip East, Helen Scott, Anne Warren, Zongxiang Zhou, Alexander Yu Nikitin, David E Neal and Ian G Mills

    Citation: BMC Medical Genomics 2008 1:17

    Content type: Research article

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  5. Atherosclerotic peripheral arterial disease (PAD) affects 8–10 million people in the United States and is associated with a marked impairment in quality of life and an increased risk of cardiovascular events. ...

    Authors: Sharon LR Kardia, M Todd Greene, Eric Boerwinkle, Stephen T Turner and Iftikhar J Kullo

    Citation: BMC Medical Genomics 2008 1:16

    Content type: Research article

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  6. DNA amplifications alter gene dosage in cancer genomes by multiplying the gene copy number. Amplifications are quintessential in a considerable number of advanced cancers of various anatomical locations. The a...

    Authors: Samuel Myllykangas, Jarkko Tikka, Tom Böhling, Sakari Knuutila and Jaakko Hollmén

    Citation: BMC Medical Genomics 2008 1:15

    Content type: Research article

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  7. Obesity and insulin resistance are two major risk factors underlying the metabolic syndrome. The development of these metabolic disorders is frequently studied, but mainly in liver, skeletal muscle, and adipos...

    Authors: Nicole JW de Wit, Hanneke Bosch-Vermeulen, Philip J de Groot, Guido JEJ Hooiveld, Mechteld M Grootte Bromhaar, Jenny Jansen, Michael Müller and Roelof van der Meer

    Citation: BMC Medical Genomics 2008 1:14

    Content type: Research article

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  8. The process of malignant transformation, progression and metastasis of melanoma is poorly understood. Gene expression profiling of human cancer has allowed for a unique insight into the genes that are involved...

    Authors: Adam I Riker, Steven A Enkemann, Oystein Fodstad, Suhu Liu, Suping Ren, Christopher Morris, Yaguang Xi, Paul Howell, Brandon Metge, Rajeev S Samant, Lalita A Shevde, Wenbin Li, Steven Eschrich, Adil Daud, Jingfang Ju and Jaime Matta

    Citation: BMC Medical Genomics 2008 1:13

    Content type: Research article

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  9. With the introduction of increasingly powerful mass spectrometry (MS) techniques for clinical research, several recent large-scale MS proteomics studies have sought to characterize the entire human plasma prot...

    Authors: Sudipto Saha, Scott H Harrison, Changyu Shen, Haixu Tang, Predrag Radivojac, Randy J Arnold, Xiang Zhang and Jake Yue Chen

    Citation: BMC Medical Genomics 2008 1:12

    Content type: Database

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  10. Dupuytren's contracture (DC) is the most common inherited connective tissue disease of humans and is hypothesized to be associated with aberrant wound healing of the palmar fascia. Fibroblasts and myofibroblas...

    Authors: Latha Satish, William A LaFramboise, David B O'Gorman, Sandra Johnson, Benjamin Janto, Bing Siang Gan, Mark E Baratz, Fen Z Hu, J Christopher Post, Garth D Ehrlich and Sandeep Kathju

    Citation: BMC Medical Genomics 2008 1:10

    Content type: Research article

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  11. Molecular characterization of breast and other cancers by gene expression profiling has corroborated existing classifications and revealed novel subtypes. Most profiling studies are based on fresh frozen (FF) ...

    Authors: Andrea Oberli, Vlad Popovici, Mauro Delorenzi, Anna Baltzer, Janine Antonov, Sybille Matthey, Stefan Aebi, Hans Jörg Altermatt and Rolf Jaggi

    Citation: BMC Medical Genomics 2008 1:9

    Content type: Technical advance

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  12. Pterostilbene, a naturally occurring phenolic compound produced by agronomically important plant genera such as Vitis and Vacciunium, is a phytoalexin exhibiting potent antifungal activity. Additionally, recent s...

    Authors: Zhiqiang Pan, Ameeta K Agarwal, Tao Xu, Qin Feng, Scott R Baerson, Stephen O Duke and Agnes M Rimando

    Citation: BMC Medical Genomics 2008 1:7

    Content type: Research article

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  13. Midkine is a heparin-binding growth factor that is over-expressed in various human cancers and plays important roles in cell transformation, growth, survival, migration, and angiogenesis. However, little is kn...

    Authors: Zongbing You, Ying Dong, Xiangtian Kong, Laurel A Beckett, Regina Gandour-Edwards and Jonathan Melamed

    Citation: BMC Medical Genomics 2008 1:6

    Content type: Research article

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  14. Arrayed primer extension (APEX) is a microarray-based rapid minisequencing methodology that may have utility in 'personalized medicine' applications that involve genetic diagnostics of single nucleotide polymo...

    Authors: Mohua Podder, Jian Ruan, Ben W Tripp, Zane E Chu and Scott J Tebbutt

    Citation: BMC Medical Genomics 2008 1:5

    Content type: Research article

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  15. Although the PBS-IIc SELDI-TOF MS apparatus has been extensively used in the search for better biomarkers, issues have been raised concerning the semi-quantitative nature of the technique and its reproducibili...

    Authors: Marie-Christine W Gast, Judith YMN Engwegen, Jan HM Schellens and Jos H Beijnen

    Citation: BMC Medical Genomics 2008 1:4

    Content type: Research article

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  16. Urothelial carcinoma (UC) is characterized by nonrandom chromosomal aberrations, varying from one or a few changes in early-stage and low-grade tumors, to highly rearranged karyotypes in muscle-invasive lesion...

    Authors: Markus Heidenblad, David Lindgren, Tord Jonson, Fredrik Liedberg, Srinivas Veerla, Gunilla Chebil, Sigurdur Gudjonsson, Åke Borg, Wiking Månsson and Mattias Höglund

    Citation: BMC Medical Genomics 2008 1:3

    Content type: Research article

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  17. The early detection of prostate cancer has resulted in an increase in the number of patients with localized prostate cancer and has paralleled the reported reduction in prostate cancer mortality. The increased...

    Authors: Timothy J McDonnell, Nikhil S Chari, Jeong Hee Cho-Vega, Patricia Troncoso, Xuemei Wang, Carlos E Bueso-Ramos, Kevin Coombes, Shawn Brisbay, Remigio Lopez, George Prendergast, Christopher Logothetis and Kim-Anh Do

    Citation: BMC Medical Genomics 2008 1:1

    Content type: Research article

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