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  1. Increased mammographic density is one of the strongest independent risk factors for breast cancer. It is believed that one third of breast cancers are derived from breasts with more than 50% density. Mammograp...

    Authors: Margarethe Biong, Inger T Gram, Ilene Brill, Fredrik Johansen, Hiroko K Solvang, Grethe IG Alnaes, Toril Fagerheim, Yngve Bremnes, Stephen J Chanock, Laurie Burdett, Meredith Yeager, Giske Ursin and Vessela N Kristensen
    Citation: BMC Medical Genomics 2010 3:9
  2. Current prostate cancer prognostic models are based on pre-treatment prostate specific antigen (PSA) levels, biopsy Gleason score, and clinical staging but in practice are inadequate to accurately predict dise...

    Authors: Andrea Sboner, Francesca Demichelis, Stefano Calza, Yudi Pawitan, Sunita R Setlur, Yujin Hoshida, Sven Perner, Hans-Olov Adami, Katja Fall, Lorelei A Mucci, Philip W Kantoff, Meir Stampfer, Swen-Olof Andersson, Eberhard Varenhorst, Jan-Erik Johansson, Mark B Gerstein…
    Citation: BMC Medical Genomics 2010 3:8
  3. Public proteomics databases such as PeptideAtlas contain peptides and proteins identified in mass spectrometry experiments. However, these databases lack information about human disease for researchers studyin...

    Authors: Jeremy Handcock, Eric W Deutsch and John Boyle
    Citation: BMC Medical Genomics 2010 3:7
  4. Childhood leukemia is characterized by the presence of balanced chromosomal translocations or by other structural or numerical chromosomal changes. It is well know that leukemias with specific molecular abnorm...

    Authors: Anna Andersson, Patrik Edén, Tor Olofsson and Thoas Fioretos
    Citation: BMC Medical Genomics 2010 3:6
  5. Chronic systemic low-grade inflammation in obese subjects is associated with health complications including cardiovascular diseases, insulin resistance and diabetes. Reducing inflammatory responses may reduce ...

    Authors: Marjan J van Erk, Suzan Wopereis, Carina Rubingh, Trinette van Vliet, Elwin Verheij, Nicole HP Cnubben, Theresa L Pedersen, John W Newman, Age K Smilde, Jan van der Greef, Henk FJ Hendriks and Ben van Ommen
    Citation: BMC Medical Genomics 2010 3:5
  6. Abberant DNA methylation at CpG dinucleotides represents a common mechanism of transcriptional silencing in cancer. Since CpG methylation is a reversible event, tumor supressor genes that have undergone silenc...

    Authors: Jill C Rubinstein, Nam Tran, Shuangge Ma, Ruth Halaban and Michael Krauthammer
    Citation: BMC Medical Genomics 2010 3:4
  7. Prevalence of obesity is increasing to pandemic proportions. However, obese subjects differ in insulin resistance, adipokine production and co-morbidities. Based on fasting plasma analysis, obese subjects were...

    Authors: Robin E MacLaren, Wei Cui, HuiLing Lu, Serge Simard and Katherine Cianflone
    Citation: BMC Medical Genomics 2010 3:3
  8. Acute erythro- and megakaryoblastic leukaemias are associated with very poor prognoses and the mechanism of blastic transformation is insufficiently elucidated. The murine Graffi leukaemia retrovirus induces e...

    Authors: Veronique Voisin, Philippe Legault, Diana Paulina Salazar Ospina, Yaacov Ben-David and Eric Rassart
    Citation: BMC Medical Genomics 2010 3:2
  9. The genetic contributions to human common disorders and mouse genetic models of disease are complex and often overlapping. In common human diseases, unlike classical Mendelian disorders, genetic factors genera...

    Authors: Yonqing Zhang, Supriyo De, John R Garner, Kirstin Smith, S Alex Wang and Kevin G Becker
    Citation: BMC Medical Genomics 2010 3:1
  10. Genome-wide association studies (GWAS) have emerged as a powerful approach for identifying susceptibility loci associated with polygenetic diseases such as type 2 diabetes mellitus (T2DM). However, it is still...

    Authors: Hemang Parikh, Valeriya Lyssenko and Leif C Groop
    Citation: BMC Medical Genomics 2009 2:72
  11. Accumulating evidence suggests that somatic stem cells undergo mutagenic transformation into cancer initiating cells. The serous subtype of ovarian adenocarcinoma in humans has been hypothesized to arise from ...

    Authors: Nathan J Bowen, L DeEtte Walker, Lilya V Matyunina, Sanjay Logani, Kimberly A Totten, Benedict B Benigno and John F McDonald
    Citation: BMC Medical Genomics 2009 2:71
  12. Prostate cancer is a world wide leading cancer and it is characterized by its aggressive metastasis. According to the clinical heterogeneity, prostate cancer displays different stages and grades related to the...

    Authors: Hsiang-Yuan Yeh, Shih-Wu Cheng, Yu-Chun Lin, Cheng-Yu Yeh, Shih-Fang Lin and Von-Wun Soo
    Citation: BMC Medical Genomics 2009 2:70
  13. Microarray technology has allowed to molecularly characterize many different cancer sites. This technology has the potential to individualize therapy and to discover new drug targets. However, due to technolog...

    Authors: Olivier Gevaert, Anneleen Daemen, Bart De Moor and Louis Libbrecht
    Citation: BMC Medical Genomics 2009 2:69
  14. Mastic oil from Pistacia lentiscus variation chia, a blend of bioactive terpenes with recognized medicinal properties, has been recently shown to exert anti-tumor growth activity through inhibition of cancer cell...

    Authors: Panagiotis Moulos, Olga Papadodima, Aristotelis Chatziioannou, Heleni Loutrari, Charis Roussos and Fragiskos N Kolisis
    Citation: BMC Medical Genomics 2009 2:68
  15. Despite the significant progress made in colon cancer chemotherapy, advanced disease remains largely incurable and novel efficacious chemotherapies are urgently needed. Histone deacetylase inhibitors (HDACi) r...

    Authors: Melissa J LaBonte, Peter M Wilson, William Fazzone, Susan Groshen, Heinz-Josef Lenz and Robert D Ladner
    Citation: BMC Medical Genomics 2009 2:67
  16. In molecular profiling studies of cancer patients, experimental and clinical data are combined in order to understand the clinical heterogeneity of the disease: clinical information for each subject needs to b...

    Authors: Irene Papatheodorou, Charles Crichton, Lorna Morris, Peter Maccallum, Jim Davies, James D Brenton and Carlos Caldas
    Citation: BMC Medical Genomics 2009 2:66
  17. Sinonasal adenocarcinomas are uncommon tumors which develop in the ethmoid sinus after exposure to wood dust. Although the etiology of these tumors is well defined, very little is known about their molecular b...

    Authors: Dominique Tripodi, Sylvia Quéméner, Karine Renaudin, Christophe Ferron, Olivier Malard, Isabelle Guisle-Marsollier, Véronique Sébille-Rivain, Christian Verger, Christian Géraut and Catherine Gratas-Rabbia-Ré
    Citation: BMC Medical Genomics 2009 2:65
  18. One intractable problem with using microarray data analysis for cancer classification is how to reduce the extremely high-dimensionality gene feature data to remove the effects of noise. Feature selection is o...

    Authors: Xiaosheng Wang and Osamu Gotoh
    Citation: BMC Medical Genomics 2009 2:64
  19. Autoimmune diabetes (T1D) onset is preceded by a long inflammatory process directed against the insulin-secreting β cells of the pancreas. Deciphering the early autoimmune mechanisms represents a challenge due...

    Authors: Béatrice Regnault, José Osorio y Fortea, Dongmei Miao, George Eisenbarth and Evie Melanitou
    Citation: BMC Medical Genomics 2009 2:63
  20. The purpose of this study was to examine the effects of glucose reduction stress on lymphoblastic cell line (LCL) gene expression in subjects with schizophrenia compared to non-psychotic relatives.

    Authors: Maureen V Martin, Brandi Rollins, P Adolfo Sequeira, Andrea Mesén, William Byerley, Richard Stein, Emily A Moon, Huda Akil, Edward G Jones, Stanley J Watson, Jack Barchas, Lynn E DeLisi, Richard M Myers, Alan Schatzberg, William E Bunney and Marquis P Vawter
    Citation: BMC Medical Genomics 2009 2:62
  21. Identification of novel cancer-causing genes is one of the main goals in cancer research. The rapid accumulation of genome-wide protein-protein interaction (PPI) data in humans has provided a new basis for stu...

    Authors: Li Li, Kangyu Zhang, James Lee, Shaun Cordes, David P Davis and Zhijun Tang
    Citation: BMC Medical Genomics 2009 2:61
  22. Full-thickness articular cartilage lesions that reach to the subchondral bone yet are restricted to the chondral compartment usually fill with a fibrocartilage-like repair tissue which is structurally and biom...

    Authors: Michael J Mienaltowski, Liping Huang, David D Frisbie, C Wayne McIlwraith, Arnold J Stromberg, Arne C Bathke and James N MacLeod
    Citation: BMC Medical Genomics 2009 2:60
  23. Pathway discovery from gene expression data can provide important insight into the relationship between signaling networks and cancer biology. Oncogenic signaling pathways are commonly inferred by comparison w...

    Authors: Sandeep Sanga, Bradley M Broom, Vittorio Cristini and Mary E Edgerton
    Citation: BMC Medical Genomics 2009 2:59
  24. In addition to their well-documented ocular therapeutic effects, glucocorticoids (GCs) can cause sight-threatening side-effects including ocular hypertension presumably via morphological and biochemical change...

    Authors: Alissar Nehmé, Edward K Lobenhofer, W Daniel Stamer and Jeffrey L Edelman
    Citation: BMC Medical Genomics 2009 2:58
  25. MicroRNAs (miRNAs) are a class of approximately 22 nucleotide long, widely expressed RNA molecules that play important regulatory roles in eukaryotes. To investigate miRNA function, it is essential that method...

    Authors: Julie M Cunningham, Ann L Oberg, Pedro M Borralho, Betsy T Kren, Amy J French, Liang Wang, Brian M Bot, Bruce W Morlan, Kevin AT Silverstein, Rod Staggs, Yan Zeng, Anne-Francoise Lamblin, Christopher A Hilker, Jian-Bing Fan, Clifford J Steer and Stephen N Thibodeau
    Citation: BMC Medical Genomics 2009 2:57
  26. Tobacco smoking is associated with lung cancer and other respiratory diseases. However, little is known about the global molecular changes that precede the appearance of clinically detectable symptoms. In this...

    Authors: Sabina Halappanavar, Marsha Russell, Martin R Stampfli, Andrew Williams and Carole L Yauk
    Citation: BMC Medical Genomics 2009 2:56
  27. Monoamine oxidase A (MAO-A), a mitochondrial enzyme that degrades monoamines including neurotransmitters, is highly expressed in basal cells of the normal human prostatic epithelium and in poorly differentiate...

    Authors: Hongjuan Zhao, Vincent Flamand and Donna M Peehl
    Citation: BMC Medical Genomics 2009 2:55
  28. MicroRNAs (miRNAs) are non-coding RNA molecules involved in post-transcriptional control of gene expression of a wide number of genes, including those involved in glucose homeostasis. Type 2 diabetes (T2D) is ...

    Authors: Blanca M Herrera, Helen E Lockstone, Jennifer M Taylor, Quin F Wills, Pamela J Kaisaki, Amy Barrett, Carme Camps, Christina Fernandez, Jiannis Ragoussis, Dominique Gauguier, Mark I McCarthy and Cecilia M Lindgren
    Citation: BMC Medical Genomics 2009 2:54
  29. One of the most striking features of the childhood malignancy neuroblastoma (NB) is its clinical heterogeneity. Although there is a great need for better clinical and biological markers to distinguish between ...

    Authors: Kaisa Thorell, Annika Bergman, Helena Carén, Staffan Nilsson, Per Kogner, Tommy Martinsson and Frida Abel
    Citation: BMC Medical Genomics 2009 2:53
  30. Microarray diagnostics of tumour samples is based on measurement of prognostic and/or predictive gene expression profiles. Typically, diagnostic profiles have been developed using bulk tumour samples with a su...

    Authors: Paul Roepman, Arenda Schuurman, Leonie JMJ Delahaye, Anke T Witteveen, Arno N Floore and Annuska M Glas
    Citation: BMC Medical Genomics 2009 2:52
  31. The pathogenesis of inflammation and fibrosis in chronic hepatitis C virus (HCV) infection remains unclear. Transgenic mice with constitutive HCV core over-expression display steatosis only. While the reasons ...

    Authors: Ming-Ling Chang, Chau-Ting Yeh, Deng-Yn Lin, Yu-Pin Ho, Chen-Ming Hsu and D Montgomery Bissell
    Citation: BMC Medical Genomics 2009 2:51
  32. Kaposi's sarcoma (KS) associated herpesvirus (KSHV) is the etiological agent of KS, a neoplasm characterized by proliferating spindle cells, extensive neoangiogenesis and a prominent inflammatory infiltrate. I...

    Authors: Vasu Punj, Hittu Matta, Sandra Schamus and Preet M Chaudhary
    Citation: BMC Medical Genomics 2009 2:50
  33. Gene expression studies require appropriate normalization methods. One such method uses stably expressed reference genes. Since suitable reference genes appear to be unique for each tissue, we have identified ...

    Authors: Boryana S Stamova, Michelle Apperson, Wynn L Walker, Yingfang Tian, Huichun Xu, Peter Adamczy, Xinhua Zhan, Da-Zhi Liu, Bradley P Ander, Isaac H Liao, Jeffrey P Gregg, Renee J Turner, Glen Jickling, Lisa Lit and Frank R Sharp
    Citation: BMC Medical Genomics 2009 2:49
  34. The genetic mechanisms of prostate tumorigenesis remain poorly understood, but with the advent of gene expression array capabilities, we can now produce a large amount of data that can be used to explore the m...

    Authors: Ivan P Gorlov, Jinyoung Byun, Olga Y Gorlova, Ana M Aparicio, Eleni Efstathiou and Christopher J Logothetis
    Citation: BMC Medical Genomics 2009 2:48
  35. The ability to predict the spatial frequency of relapses in multiple sclerosis (MS) would enable physicians to decide when to intervene more aggressively and to plan clinical trials more accurately.

    Authors: Michael Gurevich, Tamir Tuller, Udi Rubinstein, Rotem Or-Bach and Anat Achiron
    Citation: BMC Medical Genomics 2009 2:46
  36. Cerebral palsy (CP) is an upper motor neuron disease that results in a progressive movement disorder. Secondary to the neurological insult, muscles from CP patients often become spastic. Spastic muscle is char...

    Authors: Lucas R Smith, Eva Pontén, Yvette Hedström, Samuel R Ward, Henry G Chambers, Shankar Subramaniam and Richard L Lieber
    Citation: BMC Medical Genomics 2009 2:44
  37. Genomic copy number alteration (CNA) that are recurrent across multiple samples often harbor critical genes that can drive either the initiation or the progression of cancer disease. Up to now, most researcher...

    Authors: Philippe Broët, Patrick Tan, Marco Alifano, Sophie Camilleri-Broët and Sylvia Richardson
    Citation: BMC Medical Genomics 2009 2:43
  38. Meningiomas may occur either as familial tumors in two distinct disorders, familial multiple meningioma and neurofibromatosis 2 (NF2), or sporadically, as either single or multiple tumors in individuals with n...

    Authors: Yiping Shen, Fabio Nunes, Anat Stemmer-Rachamimov, Marianne James, Gayatry Mohapatra, Scott Plotkin, Rebecca A Betensky, David A Engler, Jennifer Roy, Vijaya Ramesh and James F Gusella
    Citation: BMC Medical Genomics 2009 2:42
  39. Hyperglycaemia in diabetes mellitus (DM) alters gene expression regulation in various organs and contributes to long term vascular and renal complications. We aimed to generate novel renal genome-wide gene tra...

    Authors: Yaomin Hu, Pamela J Kaisaki, Karène Argoud, Steven P Wilder, Karin J Wallace, Peng Y Woon, Christine Blancher, Lise Tarnow, Per-Henrik Groop, Samy Hadjadj, Michel Marre, Hans-Henrik Parving, Martin Farrall, Roger D Cox, Mark Lathrop, Nathalie Vionnet…
    Citation: BMC Medical Genomics 2009 2:41
  40. We have previously shown that the Gene expression Grade Index (GGI) was able to identify two subtypes of estrogen receptor (ER)-positive tumors that were associated with statistically distinct clinical outcome...

    Authors: Christine Desmedt, Anita Giobbie-Hurder, Patrick Neven, Robert Paridaens, Marie-Rose Christiaens, Ann Smeets, Françoise Lallemand, Benjamin Haibe-Kains, Giuseppe Viale, Richard D Gelber, Martine Piccart and Christos Sotiriou
    Citation: BMC Medical Genomics 2009 2:40
  41. Gastric cancers frequently show chromosomal alterations which can cause activation of oncogenes, and/or inactivation of tumour suppressor genes. In gastric cancer several chromosomal regions are described to b...

    Authors: Tineke E Buffart, Marianne Tijssen, Jamila El-Bchiri, Alex Duval, Mark A van de Wiel, Bauke Ylstra, Gerrit A Meijer and Beatriz Carvalho
    Citation: BMC Medical Genomics 2009 2:39
  42. At present, there are no clinically reliable disease markers for chronic fatigue syndrome. DNA chip microarray technology provides a method for examining the differential expression of mRNA from a large number...

    Authors: John W Gow, Suzanne Hagan, Pawel Herzyk, Celia Cannon, Peter O Behan and Abhijit Chaudhuri
    Citation: BMC Medical Genomics 2009 2:38
  43. Within estrogen receptor-positive breast cancer (ER+ BC), the expression levels of proliferation-related genes can define two clinically distinct molecular subtypes. When treated with adjuvant tamoxifen, those...

    Authors: Sherene Loi, Christos Sotiriou, Benjamin Haibe-Kains, Francoise Lallemand, Nelly M Conus, Martine J Piccart, Terence P Speed and Grant A McArthur
    Citation: BMC Medical Genomics 2009 2:37
  44. The presence of MLL rearrangements in acute leukemia results in a complex number of biological modifications that still remain largely unexplained. Armstrong et al. proposed MLL rearrangement positive ALL as a di...

    Authors: Andrea Zangrando, Marta Campo Dell'Orto, Geertruy te Kronnie and Giuseppe Basso
    Citation: BMC Medical Genomics 2009 2:36
  45. MiRNAs play important roles in cellular control and in various disease states such as cancers, where they may serve as markers or possibly even therapeutics. Identifying the whole repertoire of miRNAs and unde...

    Authors: Sanne Nygaard, Anders Jacobsen, Morten Lindow, Jens Eriksen, Eva Balslev, Henrik Flyger, Niels Tolstrup, Søren Møller, Anders Krogh and Thomas Litman
    Citation: BMC Medical Genomics 2009 2:35
  46. Cisplatin and carboplatin are the primary first-line therapies for the treatment of ovarian cancer. However, resistance to these platinum-based drugs occurs in the large majority of initially responsive tumors...

    Authors: Meng Li, Curt Balch, John S Montgomery, Mikyoung Jeong, Jae Hoon Chung, Pearlly Yan, Tim HM Huang, Sun Kim and Kenneth P Nephew
    Citation: BMC Medical Genomics 2009 2:34
  47. The use of gene expression in venous blood either as a pharmacodynamic marker in clinical trials of drugs or as a diagnostic test requires knowledge of the variability in expression over time in healthy volunt...

    Authors: Chris Karlovich, Guillemette Duchateau-Nguyen, Andrea Johnson, Patricia McLoughlin, Mercidita Navarro, Carole Fleurbaey, Lori Steiner, Michel Tessier, Tracy Nguyen, Monika Wilhelm-Seiler and John P Caulfield
    Citation: BMC Medical Genomics 2009 2:33
  48. It is well known that a persistent infection with high-risk human papillomavirus (hrHPV) is causally involved in the development of squamous cell carcinomas of the uterine cervix (CxSCCs) and a subset of SCCs ...

    Authors: Saskia M Wilting, Serge J Smeets, Peter JF Snijders, Wessel N van Wieringen, Mark A van de Wiel, Gerrit A Meijer, Bauke Ylstra, C René Leemans, Chris JLM Meijer, Ruud H Brakenhoff, Boudewijn JM Braakhuis and Renske DM Steenbergen
    Citation: BMC Medical Genomics 2009 2:32

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