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  1. Upon co-stimulation with CD3/CD28 antibodies, activated CD4 + T cells were found to lose their susceptibility to HIV-1 infection, exhibiting an induced resistant phenotype. This rather unexpected phenomenon ha...

    Authors: Wen-Wen Xu, Miao-Jun Han, Dai Chen, Ling Chen, Yan Guo, Andrew Willden, Di-Qiu Liu and Hua-Tang Zhang
    Citation: BMC Medical Genomics 2013 6:15
  2. Metabolic syndrome (MetS) is an aberration associated with increased risk for cancer and inflammation. Adiponectin, an adipocyte-produced abundant protein hormone, has countering effect on the diabetogenic and...

    Authors: Yi Zhang, Jack W Kent Jr, Michael Olivier, Omar Ali, Diana Cerjak, Ulrich Broeckel, Reham M Abdou, Thomas D Dyer, Anthony Comuzzie, Joanne E Curran, Melanie A Carless, David L Rainwater, Harald H H Göring, John Blangero and Ahmed H Kissebah
    Citation: BMC Medical Genomics 2013 6:14
  3. Hereditary non-polyposis colorectal cancer (HNPCC)/Lynch syndrome (LS) is a cancer syndrome characterised by early-onset epithelial cancers, especially colorectal cancer (CRC) and endometrial cancer. The aim o...

    Authors: Bente A Talseth-Palmer, Elizabeth G Holliday, Tiffany-Jane Evans, Mark McEvoy, John Attia, Desma M Grice, Amy L Masson, Cliff Meldrum, Allan Spigelman and Rodney J Scott
    Citation: BMC Medical Genomics 2013 6:10
  4. Fatty acid-binding proteins (FABPs) play regulatory roles at the nexus of lipid metabolism and signaling. Dyslipidemia in clinical manifestation frequently co-occurs with obesity, insulin resistance and hypert...

    Authors: Yi Zhang, Jack W Kent, Adam Lee, Diana Cerjak, Omar Ali, Robert Diasio, Michael Olivier, John Blangero, Melanie A Carless and Ahmed H Kissebah
    Citation: BMC Medical Genomics 2013 6:9
  5. The editors of BMC Medical Genomics would like to thank all our reviewers who have contributed to the journal in Volume 5 (2012).

    Authors: Tim Sands
    Citation: BMC Medical Genomics 2013 6:6
  6. Consumption of high-fat diets has negative impacts on health and well-being, some of which may be epigenetically regulated. Selenium and folate are two compounds which influence epigenetic mechanisms. We inves...

    Authors: Emma N Bermingham, Shalome A Bassett, Wayne Young, Nicole C Roy, Warren C McNabb, Janine M Cooney, Di T Brewster, William A Laing and Matthew PG Barnett
    Citation: BMC Medical Genomics 2013 6:7
  7. Cryptorchidism is the most frequent congenital disorder in male children; however the genetic causes of cryptorchidism remain poorly investigated. Comparative integratomics combined with systems biology approa...

    Authors: Carlo V Cannistraci, Jernej Ogorevc, Minja Zorc, Timothy Ravasi, Peter Dovc and Tanja Kunej
    Citation: BMC Medical Genomics 2013 6:5
  8. Human Immunodeficiency Virus-1 (HIV) infection frequently results in neurocognitive impairment. While the cause remains unclear, recent gene expression studies have identified genes whose transcription is dysr...

    Authors: Andrew J Levine, Jeremy A Miller, Paul Shapshak, Benjamin Gelman, Elyse J Singer, Charles H Hinkin, Deborah Commins, Susan Morgello, Igor Grant and Steve Horvath
    Citation: BMC Medical Genomics 2013 6:4
  9. Ring chromosome 6 is a rare constitutional abnormality that generally occurs de novo. The related phenotype may be highly variable ranging from an almost normal phenotype to severe malformations and mental retard...

    Authors: Laura Ciocca, Cecilia Surace, Maria Cristina Digilio, Maria Cristina Roberti, Pietro Sirleto, Antonietta Lombardo, Serena Russo, Valerio Brizi, Simona Grotta, Claudio Cini and Adriano Angioni
    Citation: BMC Medical Genomics 2013 6:3
  10. Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited. We hypothesize that more gene sets can be created by next-gene...

    Authors: Kristina M Hettne, André Boorsma, Dorien A M van Dartel, Jelle J Goeman, Esther de Jong, Aldert H Piersma, Rob H Stierum, Jos C Kleinjans and Jan A Kors
    Citation: BMC Medical Genomics 2013 6:2
  11. A number of neurodevelopmental syndromes are caused by mutations in genes encoding proteins that normally function in epigenetic regulation. Identification of epigenetic alterations occurring in these disorder...

    Authors: Daria Grafodatskaya, Barian HY Chung, Darci T Butcher, Andrei L Turinsky, Sarah J Goodman, Sana Choufani, Yi-An Chen, Youliang Lou, Chunhua Zhao, Rageen Rajendram, Fatima E Abidi, Cindy Skinner, James Stavropoulos, Carolyn A Bondy, Jill Hamilton, Shoshana Wodak…
    Citation: BMC Medical Genomics 2013 6:1
  12. Schizophrenia (SCZ) and type 2 diabetes mellitus (T2D) are both complex diseases. Accumulated studies indicate that schizophrenia patients are prone to present the type 2 diabetes symptoms, but the potential m...

    Authors: Yanli Liu, Zezhi Li, Meixia Zhang, Youping Deng, Zhenghui Yi and Tieliu Shi
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S17

    This article is part of a Supplement: Volume 6 Supplement 1

  13. Next generation sequencing (NGS) technologies have greatly facilitated the rapid and economical detection of pathogenic mutations in human disorders. However, mutation descriptions are hard to be compared and ...

    Authors: Meiwen Jia, Yanli Liu, Zhongchao Shen, Chen Zhao, Meixia Zhang, Zhenghui Yi, Chengping Wen, Youping Deng and Tieliu Shi
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S16

    This article is part of a Supplement: Volume 6 Supplement 1

  14. In HBV-infected patients, different genotypes of the hepatitis B virus influence liver disease progression and response to antiviral therapy. Moreover, long-term antiviral therapy will eventually select for dr...

    Authors: Fanjun Wang, Lili Lu, Changshun Yu, Zhanwu Lv, Xuelian Luo, Chao Wan, Zhaohui Hu, Qinyi Zhu, Youping Deng and Chuyu Zhang
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S15

    This article is part of a Supplement: Volume 6 Supplement 1

  15. MicroRNAs (miRNAs) are short non-coding RNA molecules that regulate mRNA transcript levels and translation. Deregulation of microRNAs is indicated in a number of diseases and microRNAs are seen as a promising ...

    Authors: Rehman Qureshi and Ahmet Sacan
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S14

    This article is part of a Supplement: Volume 6 Supplement 1

  16. DNA methylation is an inheritable chemical modification of cytosine, and represents one of the most important epigenetic events. Computational prediction of the DNA methylation status can be employed to speed ...

    Authors: Hao Zheng, Hongwei Wu, Jinping Li and Shi-Wen Jiang
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S13

    This article is part of a Supplement: Volume 6 Supplement 1

  17. Insulin resistance is a key element in the pathogenesis of type 2 diabetes mellitus. Plasma free fatty acids were assumed to mediate the insulin resistance, while the relationship between lipid and glucose dis...

    Authors: Chen Zhao, Jinghe Mao, Junmei Ai, Ming Shenwu, Tieliu Shi, Daqing Zhang, Xiaonan Wang, Yunliang Wang and Youping Deng
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S12

    This article is part of a Supplement: Volume 6 Supplement 1

  18. Understanding how genes are expressed specifically in particular tissues is a fundamental question in developmental biology. Many tissue-specific genes are involved in the pathogenesis of complex human disease...

    Authors: Shaolei Teng, Jack Y Yang and Liangjiang Wang
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S10

    This article is part of a Supplement: Volume 6 Supplement 1

  19. It is well known that DNA methylation, as an epigenetic factor, has an important effect on gene expression and disease development. Detecting differentially methylated loci under different conditions, such as ...

    Authors: Zhongxue Chen, Hanwen Huang, Jianzhong Liu, Hon Keung Tony Ng, Saralees Nadarajah, Xudong Huang and Youping Deng
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S9

    This article is part of a Supplement: Volume 6 Supplement 1

  20. Computational genomics of Alzheimer disease (AD), the most common form of senile dementia, is a nascent field in AD research. The field includes AD gene clustering by computing gene order which generates highe...

    Authors: Benqiong Hu, Gang Jiang, Chaoyang Pang, Shipeng Wang, Qingzhong Liu, Zhongxue Chen, Charles R Vanderburg, Jack T Rogers, Youping Deng and Xudong Huang
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S8

    This article is part of a Supplement: Volume 6 Supplement 1

  21. Over 10,000 long intergenic non-coding RNAs (lincRNAs) have been identified in the human genome. Some have been well characterized and known to participate in various stages of gene regulation. In the post-tra...

    Authors: Liran Juan, Guohua Wang, Milan Radovich, Bryan P Schneider, Susan E Clare, Yadong Wang and Yunlong Liu
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S7

    This article is part of a Supplement: Volume 6 Supplement 1

  22. Early detection of breast cancer in blood is both appealing clinically and challenging technically due to the disease's illusive nature and heterogeneity. Today, even though major breast cancer subtypes have b...

    Authors: Fan Zhang and Jake Y Chen
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S6

    This article is part of a Supplement: Volume 6 Supplement 1

  23. Bidirectional promoters are shared promoter sequences between divergent gene pair (genes proximal to each other on opposite strands), and can regulate the genes in both directions. In the human genome, > 10% o...

    Authors: Guohua Wang, Ke Qi, Yuming Zhao, Yu Li, Liran Juan, Mingxiang Teng, Lang Li, Yunlong Liu and Yadong Wang
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S5

    This article is part of a Supplement: Volume 6 Supplement 1

  24. Breast cancer is worldwide the second most common type of cancer after lung cancer. Traditional mammography and Tissue Microarray has been studied for early cancer detection and cancer prediction. However, the...

    Authors: Fan Zhang, Howard L Kaufman, Youping Deng and Renee Drabier
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S4

    This article is part of a Supplement: Volume 6 Supplement 1

  25. One of the challenges in classification of cancer tissue samples based on gene expression data is to establish an effective method that can select a parsimonious set of informative genes. The Top Scoring Pair ...

    Authors: Haiyan Wang, Hongyan Zhang, Zhijun Dai, Ming-shun Chen and Zheming Yuan
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S3

    This article is part of a Supplement: Volume 6 Supplement 1

  26. Cadmium (Cd2+) is a known nephrotoxin causing tubular necrosis during acute exposure and potentially contributing to renal failure in chronic long-term exposure. To investigate changes in global gene expression e...

    Authors: Scott H Garrett, Kaitlin Clarke, Donald A Sens, Youping Deng, Seema Somji and Ke K Zhang
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S2

    This article is part of a Supplement: Volume 6 Supplement 1

  27. This is an introduction to the supplement to BMC Medical Genomics that includes16 papers selected from the 2011 World Congress in Computer Science, Computer Engineering, Applied Computing as well as other sources...

    Authors: Ke K Zhang, Hamid R Arabnia, Yunliang Wang and Youping Deng
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S1

    This article is part of a Supplement: Volume 6 Supplement 1

  28. Colorectal cancer (CRC) is a heterogeneous and biologically poorly understood disease. To tailor CRC treatment, it is essential to first model this heterogeneity by defining subtypes of patients with homogeneo...

    Authors: Andreas Schlicker, Garry Beran, Christine M Chresta, Gael McWalter, Alison Pritchard, Susie Weston, Sarah Runswick, Sara Davenport, Kerry Heathcote, Denis Alferez Castro, George Orphanides, Tim French and Lodewyk FA Wessels
    Citation: BMC Medical Genomics 2012 5:66
  29. The SH2B1 gene (Src-homology 2B adaptor protein 1 gene) is a solid candidate gene for obesity. Large scale GWAS studies depicted markers in the vicinity of the gene; animal models suggest a potential relevance fo...

    Authors: Anna-Lena Volckmar, Florian Bolze, Ivonne Jarick, Nadja Knoll, André Scherag, Thomas Reinehr, Thomas Illig, Harald Grallert, Heinz-Erich Wichmann, Susanna Wiegand, Heike Biebermann, Heiko Krude, Pamela Fischer-Posovszky, Winfried Rief, Martin Wabitsch, Martin Klingenspor…
    Citation: BMC Medical Genomics 2012 5:65
  30. Chronic obstructive pulmonary disease (COPD) is influenced by both environmental and genetic factors. Few gene studies of the Chinese population have focused on COPD. We investigated candidate genes associated...

    Authors: Yi Guo, Yi Gong, Chunming Pan, Yanrong Qian, Guochao Shi, Qijian Cheng, Qingyun Li, Lei Ren, Qiuling Weng, Yi Chen, Ting Cheng, Liang Fan, Zhihong Jiang and Huanying Wan
    Citation: BMC Medical Genomics 2012 5:64
  31. We explore the benefits of applying a new proportional hazard model to analyze survival of breast cancer patients. As a parametric model, the hypertabastic survival model offers a closer fit to experimental da...

    Authors: Mohammad A Tabatabai, Wayne M Eby, Nadim Nimeh, Hong Li and Karan P Singh
    Citation: BMC Medical Genomics 2012 5:63
  32. Mitochondrial proteomic alterations of nasopharyngeal carcinoma metastasis remain unknown. Our purpose is to screen mitochondrial proteins for the elucidation of the molecular mechanisms of nasopharyngeal carc...

    Authors: Jianping Liu, Xianquan Zhan, Maoyu Li, Guoqing Li, Pengfei Zhang, Zhefeng Xiao, Meiying Shao, Fang Peng, Rong Hu and Zhuchu Chen
    Citation: BMC Medical Genomics 2012 5:62
  33. High serum triglyceride (TG) levels is an established risk factor for coronary heart disease (CHD). Fat is stored in the form of TGs in human adipose tissue. We hypothesized that gene co-expression networks in...

    Authors: Blake E Haas, Steve Horvath, Kirsi H Pietiläinen, Rita M Cantor, Elina Nikkola, Daphna Weissglas-Volkov, Aila Rissanen, Mete Civelek, Ivette Cruz-Bautista, Laura Riba, Johanna Kuusisto, Jaakko Kaprio, Teresa Tusie-Luna, Markku Laakso, Carlos A Aguilar-Salinas and Päivi Pajukanta
    Citation: BMC Medical Genomics 2012 5:61
  34. Alternative exon usage (AEU) is an important component of gene regulation. Exon expression platforms allow the detection of associations between AEU and phenotypes such as cancer. Numerous studies have identif...

    Authors: Ahmed Sadeque, Nicola VL Serão, Bruce R Southey, Kristin R Delfino and Sandra L Rodriguez-Zas
    Citation: BMC Medical Genomics 2012 5:59
  35. Smoking is the leading cause of preventable death worldwide and has been shown to increase the risk of multiple diseases including coronary artery disease (CAD). We sought to identify genes whose levels of exp...

    Authors: Philip Beineke, Karen Fitch, Heng Tao, Michael R Elashoff, Steven Rosenberg, William E Kraus and James A Wingrove
    Citation: BMC Medical Genomics 2012 5:58
  36. Conventional prenatal screening tests, such as maternal serum tests and ultrasound scan, have limited resolution and accuracy.

    Authors: Fuman Jiang, Jinghui Ren, Fang Chen, Yuqiu Zhou, Jiansheng Xie, Shan Dan, Yue Su, Jianhong Xie, Baomin Yin, Wen Su, Huakun Zhang, Wei Wang, Xianghua Chai, Linhua Lin, Hui Guo, Qiyun Li…
    Citation: BMC Medical Genomics 2012 5:57
  37. The genetic etiology of autism is heterogeneous. Multiple disorders share genotypic and phenotypic traits with autism. Network based cross-disorder analysis can aid in the understanding and characterization of...

    Authors: Tristan H Nelson, Jae-Yoon Jung, Todd F DeLuca, Byron K Hinebaugh, Kristian Che St Gabriel and Dennis P Wall
    Citation: BMC Medical Genomics 2012 5:56
  38. Despite entering complete remission after primary treatment, a substantial proportion of patients with early stage breast cancer will develop metastases. Prediction of such an outcome remains challenging despi...

    Authors: Françoise Bonnet, Mickael Guedj, Natalie Jones, Sana Sfar, Véronique Brouste, Nabila Elarouci, Guillaume Banneau, Béatrice Orsetti, Charlotte Primois, Christine Tunon de Lara, Marc Debled, Isabelle de Mascarel, Charles Theillet, Nicolas Sévenet, Aurélien de Reynies, Gaëtan MacGrogan…
    Citation: BMC Medical Genomics 2012 5:54
  39. Leukocyte infiltration plays an important role in the pathogenesis and progression of myositis, and is highly associated with disease severity. Currently, there is a lack of: efficacious therapies for myositis...

    Authors: Wei Zhu, Katie Streicher, Nan Shen, Brandon W Higgs, Chris Morehouse, Lydia Greenlees, Anthony A Amato, Koustubh Ranade, Laura Richman, David Fiorentino, Bahija Jallal, Steven A Greenberg and Yihong Yao
    Citation: BMC Medical Genomics 2012 5:53
  40. Rectal cancer is one of the most common cancers in the world. Early detection and early therapy are important for the control of death caused by rectal cancer. The present study aims to investigate the genomic...

    Authors: Zhi-Zhou Shi, Yue-Ming Zhang, Li Shang, Jia-Jie Hao, Tong-Tong Zhang, Bo-Shi Wang, Jian-Wei Liang, Xi Chen, Ying Zhang, Gui-Qi Wang, Ming-Rong Wang and Yu Zhang
    Citation: BMC Medical Genomics 2012 5:52
  41. The purpose of this study is to assess the predictive accuracy of a multi-gene predictor of response to docetaxel, 5-fluorouracil, epirubicin and cyclophosphamide combination chemotherapy on gene expression da...

    Authors: Kui Shen, Yuan Qi, Nan Song, Chunqiao Tian, Shara D Rice, Michael J Gabrin, Stacey L Brower, William Fraser Symmans, Joyce A O’Shaughnessy, Frankie A Holmes, Lina Asmar and Lajos Pusztai
    Citation: BMC Medical Genomics 2012 5:51
  42. Anatomic and physiological similarities to the human make swine an excellent large animal model for human health and disease.

    Authors: Eric M Walters, Eckhard Wolf, Jeffery J Whyte, Jiude Mao, Simone Renner, Hiroshi Nagashima, Eiji Kobayashi, Jianguo Zhao, Kevin D Wells, John K Critser, Lela K Riley and Randall S Prather
    Citation: BMC Medical Genomics 2012 5:55
  43. Aortopathies are a group of disorders characterized by aneurysms, dilation, and tortuosity of the aorta. Because of the phenotypic overlap and genetic heterogeneity of diseases featuring aortopathy, molecular ...

    Authors: Whitney L Wooderchak-Donahue, Brendan O’Fallon, Larissa V Furtado, Jacob D Durtschi, Parker Plant, Perry G Ridge, Alan F Rope, Angela T Yetman and Pinar Bayrak-Toydemir
    Citation: BMC Medical Genomics 2012 5:50
  44. Inattentiveness, impulsivity and hyperactivity are the primary behaviors associated with attention-deficit hyperactivity disorder (ADHD). Previous studies showed that peripheral blood gene expression signature...

    Authors: Yingfang Tian, Boryana Stamova, Bradley P Ander, Glen C Jickling, Joan R Gunther, Blythe A Corbett, Netty GP Bos-Veneman, Pieter J Hoekstra, Julie B Schweitzer and Frank R Sharp
    Citation: BMC Medical Genomics 2012 5:49

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