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  1. Schizophrenia (SCZ) and type 2 diabetes mellitus (T2D) are both complex diseases. Accumulated studies indicate that schizophrenia patients are prone to present the type 2 diabetes symptoms, but the potential m...

    Authors: Yanli Liu, Zezhi Li, Meixia Zhang, Youping Deng, Zhenghui Yi and Tieliu Shi
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S17
    Content type: Research Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  2. MicroRNAs (miRNAs) are short non-coding RNA molecules that regulate mRNA transcript levels and translation. Deregulation of microRNAs is indicated in a number of diseases and microRNAs are seen as a promising ...

    Authors: Rehman Qureshi and Ahmet Sacan
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S14
    Content type: Research Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  3. DNA methylation is an inheritable chemical modification of cytosine, and represents one of the most important epigenetic events. Computational prediction of the DNA methylation status can be employed to speed ...

    Authors: Hao Zheng, Hongwei Wu, Jinping Li and Shi-Wen Jiang
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S13
    Content type: Research Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  4. Computational genomics of Alzheimer disease (AD), the most common form of senile dementia, is a nascent field in AD research. The field includes AD gene clustering by computing gene order which generates highe...

    Authors: Benqiong Hu, Gang Jiang, Chaoyang Pang, Shipeng Wang, Qingzhong Liu, Zhongxue Chen, Charles R Vanderburg, Jack T Rogers, Youping Deng and Xudong Huang
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S8
    Content type: Research Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  5. Early detection of breast cancer in blood is both appealing clinically and challenging technically due to the disease's illusive nature and heterogeneity. Today, even though major breast cancer subtypes have b...

    Authors: Fan Zhang and Jake Y Chen
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S6
    Content type: Research Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  6. Breast cancer is worldwide the second most common type of cancer after lung cancer. Traditional mammography and Tissue Microarray has been studied for early cancer detection and cancer prediction. However, the...

    Authors: Fan Zhang, Howard L Kaufman, Youping Deng and Renee Drabier
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S4
    Content type: Research Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  7. Cadmium (Cd2+) is a known nephrotoxin causing tubular necrosis during acute exposure and potentially contributing to renal failure in chronic long-term exposure. To investigate changes in global gene expression e...

    Authors: Scott H Garrett, Kaitlin Clarke, Donald A Sens, Youping Deng, Seema Somji and Ke K Zhang
    Citation: BMC Medical Genomics 2013 6(Suppl 1):S2
    Content type: Research Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  8. Colorectal cancer (CRC) is a heterogeneous and biologically poorly understood disease. To tailor CRC treatment, it is essential to first model this heterogeneity by defining subtypes of patients with homogeneo...

    Authors: Andreas Schlicker, Garry Beran, Christine M Chresta, Gael McWalter, Alison Pritchard, Susie Weston, Sarah Runswick, Sara Davenport, Kerry Heathcote, Denis Alferez Castro, George Orphanides, Tim French and Lodewyk FA Wessels
    Citation: BMC Medical Genomics 2012 5:66
    Content type: Research article Published on:

  9. The SH2B1 gene (Src-homology 2B adaptor protein 1 gene) is a solid candidate gene for obesity. Large scale GWAS studies depicted markers in the vicinity of the gene; animal models suggest a potential relevance fo...

    Authors: Anna-Lena Volckmar, Florian Bolze, Ivonne Jarick, Nadja Knoll, André Scherag, Thomas Reinehr, Thomas Illig, Harald Grallert, Heinz-Erich Wichmann, Susanna Wiegand, Heike Biebermann, Heiko Krude, Pamela Fischer-Posovszky, Winfried Rief, Martin Wabitsch, Martin Klingenspor…
    Citation: BMC Medical Genomics 2012 5:65
    Content type: Research article Published on:

  10. Chronic obstructive pulmonary disease (COPD) is influenced by both environmental and genetic factors. Few gene studies of the Chinese population have focused on COPD. We investigated candidate genes associated...

    Authors: Yi Guo, Yi Gong, Chunming Pan, Yanrong Qian, Guochao Shi, Qijian Cheng, Qingyun Li, Lei Ren, Qiuling Weng, Yi Chen, Ting Cheng, Liang Fan, Zhihong Jiang and Huanying Wan
    Citation: BMC Medical Genomics 2012 5:64
    Content type: Research article Published on:

  11. We explore the benefits of applying a new proportional hazard model to analyze survival of breast cancer patients. As a parametric model, the hypertabastic survival model offers a closer fit to experimental da...

    Authors: Mohammad A Tabatabai, Wayne M Eby, Nadim Nimeh, Hong Li and Karan P Singh
    Citation: BMC Medical Genomics 2012 5:63
    Content type: Research article Published on:

  12. Mitochondrial proteomic alterations of nasopharyngeal carcinoma metastasis remain unknown. Our purpose is to screen mitochondrial proteins for the elucidation of the molecular mechanisms of nasopharyngeal carc...

    Authors: Jianping Liu, Xianquan Zhan, Maoyu Li, Guoqing Li, Pengfei Zhang, Zhefeng Xiao, Meiying Shao, Fang Peng, Rong Hu and Zhuchu Chen
    Citation: BMC Medical Genomics 2012 5:62
    Content type: Research article Published on:

  13. High serum triglyceride (TG) levels is an established risk factor for coronary heart disease (CHD). Fat is stored in the form of TGs in human adipose tissue. We hypothesized that gene co-expression networks in...

    Authors: Blake E Haas, Steve Horvath, Kirsi H Pietiläinen, Rita M Cantor, Elina Nikkola, Daphna Weissglas-Volkov, Aila Rissanen, Mete Civelek, Ivette Cruz-Bautista, Laura Riba, Johanna Kuusisto, Jaakko Kaprio, Teresa Tusie-Luna, Markku Laakso, Carlos A Aguilar-Salinas and Päivi Pajukanta
    Citation: BMC Medical Genomics 2012 5:61
    Content type: Research article Published on:

  15. Alternative exon usage (AEU) is an important component of gene regulation. Exon expression platforms allow the detection of associations between AEU and phenotypes such as cancer. Numerous studies have identif...

    Authors: Ahmed Sadeque, Nicola VL Serão, Bruce R Southey, Kristin R Delfino and Sandra L Rodriguez-Zas
    Citation: BMC Medical Genomics 2012 5:59
    Content type: Research article Published on:

  16. Smoking is the leading cause of preventable death worldwide and has been shown to increase the risk of multiple diseases including coronary artery disease (CAD). We sought to identify genes whose levels of exp...

    Authors: Philip Beineke, Karen Fitch, Heng Tao, Michael R Elashoff, Steven Rosenberg, William E Kraus and James A Wingrove
    Citation: BMC Medical Genomics 2012 5:58
    Content type: Research article Published on:

  17. Conventional prenatal screening tests, such as maternal serum tests and ultrasound scan, have limited resolution and accuracy.

    Authors: Fuman Jiang, Jinghui Ren, Fang Chen, Yuqiu Zhou, Jiansheng Xie, Shan Dan, Yue Su, Jianhong Xie, Baomin Yin, Wen Su, Huakun Zhang, Wei Wang, Xianghua Chai, Linhua Lin, Hui Guo, Qiyun Li…
    Citation: BMC Medical Genomics 2012 5:57
    Content type: Technical advance Published on:

  18. The genetic etiology of autism is heterogeneous. Multiple disorders share genotypic and phenotypic traits with autism. Network based cross-disorder analysis can aid in the understanding and characterization of...

    Authors: Tristan H Nelson, Jae-Yoon Jung, Todd F DeLuca, Byron K Hinebaugh, Kristian Che St Gabriel and Dennis P Wall
    Citation: BMC Medical Genomics 2012 5:56
    Content type: Database Published on:

  19. Despite entering complete remission after primary treatment, a substantial proportion of patients with early stage breast cancer will develop metastases. Prediction of such an outcome remains challenging despi...

    Authors: Françoise Bonnet, Mickael Guedj, Natalie Jones, Sana Sfar, Véronique Brouste, Nabila Elarouci, Guillaume Banneau, Béatrice Orsetti, Charlotte Primois, Christine Tunon de Lara, Marc Debled, Isabelle de Mascarel, Charles Theillet, Nicolas Sévenet, Aurélien de Reynies, Gaëtan MacGrogan…
    Citation: BMC Medical Genomics 2012 5:54
    Content type: Research article Published on:

  20. Leukocyte infiltration plays an important role in the pathogenesis and progression of myositis, and is highly associated with disease severity. Currently, there is a lack of: efficacious therapies for myositis...

    Authors: Wei Zhu, Katie Streicher, Nan Shen, Brandon W Higgs, Chris Morehouse, Lydia Greenlees, Anthony A Amato, Koustubh Ranade, Laura Richman, David Fiorentino, Bahija Jallal, Steven A Greenberg and Yihong Yao
    Citation: BMC Medical Genomics 2012 5:53
    Content type: Research article Published on:

  21. Rectal cancer is one of the most common cancers in the world. Early detection and early therapy are important for the control of death caused by rectal cancer. The present study aims to investigate the genomic...

    Authors: Zhi-Zhou Shi, Yue-Ming Zhang, Li Shang, Jia-Jie Hao, Tong-Tong Zhang, Bo-Shi Wang, Jian-Wei Liang, Xi Chen, Ying Zhang, Gui-Qi Wang, Ming-Rong Wang and Yu Zhang
    Citation: BMC Medical Genomics 2012 5:52
    Content type: Research article Published on:

  22. The purpose of this study is to assess the predictive accuracy of a multi-gene predictor of response to docetaxel, 5-fluorouracil, epirubicin and cyclophosphamide combination chemotherapy on gene expression da...

    Authors: Kui Shen, Yuan Qi, Nan Song, Chunqiao Tian, Shara D Rice, Michael J Gabrin, Stacey L Brower, William Fraser Symmans, Joyce A O’Shaughnessy, Frankie A Holmes, Lina Asmar and Lajos Pusztai
    Citation: BMC Medical Genomics 2012 5:51
    Content type: Research article Published on:

  23. Anatomic and physiological similarities to the human make swine an excellent large animal model for human health and disease.

    Authors: Eric M Walters, Eckhard Wolf, Jeffery J Whyte, Jiude Mao, Simone Renner, Hiroshi Nagashima, Eiji Kobayashi, Jianguo Zhao, Kevin D Wells, John K Critser, Lela K Riley and Randall S Prather
    Citation: BMC Medical Genomics 2012 5:55
    Content type: Review Published on:

  24. Aortopathies are a group of disorders characterized by aneurysms, dilation, and tortuosity of the aorta. Because of the phenotypic overlap and genetic heterogeneity of diseases featuring aortopathy, molecular ...

    Authors: Whitney L Wooderchak-Donahue, Brendan O’Fallon, Larissa V Furtado, Jacob D Durtschi, Parker Plant, Perry G Ridge, Alan F Rope, Angela T Yetman and Pinar Bayrak-Toydemir
    Citation: BMC Medical Genomics 2012 5:50
    Content type: Research article Published on:

  25. Inattentiveness, impulsivity and hyperactivity are the primary behaviors associated with attention-deficit hyperactivity disorder (ADHD). Previous studies showed that peripheral blood gene expression signature...

    Authors: Yingfang Tian, Boryana Stamova, Bradley P Ander, Glen C Jickling, Joan R Gunther, Blythe A Corbett, Netty GP Bos-Veneman, Pieter J Hoekstra, Julie B Schweitzer and Frank R Sharp
    Citation: BMC Medical Genomics 2012 5:49
    Content type: Research article Published on:

  26. Pheochromocytoma and neuroblastoma are the most common neural crest-derived tumors in adults and children, respectively. We have performed a large-scale in silico analysis of altogether 1784 neuroblastoma and ...

    Authors: Peter M Szabó, Miklós Pintér, Diana Rita Szabó, Adrienn Zsippai, Attila Patócs, András Falus, Károly Rácz and Peter Igaz
    Citation: BMC Medical Genomics 2012 5:48
    Content type: Research article Published on:

  27. Epithelial ovarian cancer is characterized by multiple genomic alterations; most are passenger alterations which do not confer tumor growth. Like many cancers, it is a heterogeneous disease and can be broadly ...

    Authors: Ruby YunJu Huang, Geng Bo Chen, Noriomi Matsumura, Hung-Cheng Lai, Seiichi Mori, Jingjing Li, Meng Kang Wong, Ikuo Konishi, Jean-Paul Thiery and Liang Goh
    Citation: BMC Medical Genomics 2012 5:47
    Content type: Research article Published on:

  28. It is accepted that a woman's lifetime risk of developing breast cancer after menopause is reduced by early full term pregnancy and multiparity. This phenomenon is thought to be associated with the development...

    Authors: Suraj Peri, Ricardo López de Cicco, Julia Santucci-Pereira, Michael Slifker, Eric A Ross, Irma H Russo, Patricia A Russo, Alan A Arslan, Ilana Belitskaya-Lévy, Anne Zeleniuch-Jacquotte, Pal Bordas, Per Lenner, Janet Åhman, Yelena Afanasyeva, Robert Johansson, Fathima Sheriff…
    Citation: BMC Medical Genomics 2012 5:46
    Content type: Research article Published on:

  30. Many methodologies have been used in research to identify the “intrinsic” subtypes of breast cancer commonly known as Luminal A, Luminal B, HER2-Enriched (HER2-E) and Basal-like. The PAM50 gene set is often us...

    Authors: Roy RL Bastien, Álvaro Rodríguez-Lescure, Mark TW Ebbert, Aleix Prat, Blanca Munárriz, Leslie Rowe, Patricia Miller, Manuel Ruiz-Borrego, Daniel Anderson, Bradley Lyons, Isabel Álvarez, Tracy Dowell, David Wall, Miguel Ángel Seguí, Lee Barley, Kenneth M Boucher…
    Citation: BMC Medical Genomics 2012 5:44
    Content type: Research article Published on:

  31. The identification of genes that predict in vitro cellular chemosensitivity of cancer cells is of great importance. Chemosensitivity related genes (CRGs) have been widely utilized to guide clinical and cancer ...

    Authors: Xin Chen, Wei Jiang, Qianghu Wang, Teng Huang, Peng Wang, Yan Li, Xiaowen Chen, Yingli Lv and Xia Li
    Citation: BMC Medical Genomics 2012 5:43
    Content type: Research article Published on:

  32. We carried out a candidate gene association study in pediatric acute lymphoblastic leukemia (ALL) to identify possible genetic risk factors in a Hungarian population.

    Authors: Orsolya Lautner-Csorba, András Gézsi, Ágnes F Semsei, Péter Antal, Dániel J Erdélyi, Géza Schermann, Nóra Kutszegi, Katalin Csordás, Márta Hegyi, Gábor Kovács, András Falus and Csaba Szalai
    Citation: BMC Medical Genomics 2012 5:42
    Content type: Research article Published on:

  33. Glioblastoma (GBM) is the most common and lethal primary brain tumor in adults. Several recent transcriptomic studies in GBM have identified different signatures involving immune genes associated with GBM path...

    Authors: Elodie Vauléon, Avril Tony, Abderrahmane Hamlat, Amandine Etcheverry, Dan Cristian Chiforeanu, Philippe Menei, Jean Mosser, Véronique Quillien and Marc Aubry
    Citation: BMC Medical Genomics 2012 5:41
    Content type: Research article Published on:

  34. MicroRNA is a naturally occurring class of non-coding RNA molecules that mediate posttranscriptional gene regulation and are strongly implicated in cellular processes such as cell proliferation, carcinogenesis...

    Authors: Iver Nordentoft, Karin Birkenkamp-Demtroder, Mads Agerbæk, Dan Theodorescu, Marie Stampe Ostenfeld, Arndt Hartmann, Michael Borre, Torben F Ørntoft and Lars Dyrskjøt
    Citation: BMC Medical Genomics 2012 5:40
    Content type: Research article Published on:

  35. Breast cancer is a heterogeneous disease for which prognosis and treatment strategies are largely governed by the receptor status (estrogen, progesterone and Her2) of the tumor cells. Gene expression profiling...

    Authors: Julia Tchou, Andrew V Kossenkov, Lisa Chang, Celine Satija, Meenhard Herlyn, Louise C Showe and Ellen Puré
    Citation: BMC Medical Genomics 2012 5:39
    Content type: Research article Published on:

  36. By regulating digestion and absorption of nutrients and providing a barrier against the external environment the intestine provides a crucial contribution to the maintenance of health. To what extent aging-rel...

    Authors: Wilma T Steegenga, Nicole JW de Wit, Mark V Boekschoten, Noortje IJssennagger, Carolien Lute, Shohreh Keshtkar, Mechteld M Grootte Bromhaar, Ellen Kampman, Lisette C de Groot and Michael Muller
    Citation: BMC Medical Genomics 2012 5:38
    Content type: Research article Published on:

  37. Imatinib mesylate is currently the drug of choice to treat chronic myeloid leukemia. However, patient resistance and cytotoxicity make secondary lines of treatment, such as omacetaxine mepesuccinate, a necessi...

    Authors: Hemant Kulkarni, Harald H H Göring, Vincent Diego, Shelley Cole, Ken R Walder, Greg R Collier, John Blangero and Melanie A Carless
    Citation: BMC Medical Genomics 2012 5:37
    Content type: Research article Published on:

  38. Gankyrin was originally purified and characterized as the p28 component of the 26S proteasome, and later identified as an oncogenic protein in hepatocellular carcinomas (HCC). It has recently been found to be ...

    Authors: Xue Luo, Liang Chen, Jiang Dai, Yanfei Gao, Hongli Wang, Na Wang, Yongqiang Zhao, Feng Liu, Zhihong Sang, Jie Wang, Weihua Li, Kun He, Baofeng Jin, Jianghong Man, Wei Zhang and Qing Xia
    Citation: BMC Medical Genomics 2012 5:36
    Content type: Research article Published on:

  39. Affymetrix GeneChips and Illumina BeadArrays are the most widely used commercial single channel gene expression microarrays. Public data repositories are an extremely valuable resource, providing array-derived...

    Authors: Arran K Turnbull, Robert R Kitchen, Alexey A Larionov, Lorna Renshaw, J Michael Dixon and Andrew H Sims
    Citation: BMC Medical Genomics 2012 5:35
    Content type: Research article Published on:

  40. While there is strong evidence for phosphatidylinositol 3-kinase (PI3K) involvement in cancer development, there is limited information about the role of PI3K regulatory subunits. PIK3R3, the gene that encodes...

    Authors: Jin Zhou, Geng Bo Chen, Yew Chung Tang, Rohit Anthony Sinha, Yonghui Wu, Chui Sun Yap, Guihua Wang, Junbo Hu, Xianmin Xia, Patrick Tan, Liang Kee Goh and Paul Michael Yen
    Citation: BMC Medical Genomics 2012 5:34
    Content type: Research article Published on:

  41. MicroRNAs (miRNAs) are a class of small RNAs that have been linked to a number of diseases including cancer. The potential application of miRNAs in the diagnostics and therapeutics of ovarian and other cancers...

    Authors: Shubin W Shahab, Lilya V Matyunina, Christopher G Hill, Lijuan Wang, Roman Mezencev, L DeEtte Walker and John F McDonald
    Citation: BMC Medical Genomics 2012 5:33
    Content type: Research article Published on:

  42. Sulfamethoxazole (SMX) is a commonly used antibiotic for prevention of infectious diseases associated with HIV/AIDS and immune-compromised states. SMX-induced hypersensitivity is an idiosyncratic cutaneous dru...

    Authors: Danxin Wang, Amanda Curtis, Audrey C Papp, Susan L Koletar and Michael F Para
    Citation: BMC Medical Genomics 2012 5:32
    Content type: Research article Published on:

  45. Erythropoietin (EPO) is known to improve exercise performance by increasing oxygen blood transport and thus inducing a higher maximum oxygen uptake (VO2max). Furthermore, treatment with (or overexpression of) EPO...

    Authors: Laurence Mille-Hamard, Veronique L Billat, Elodie Henry, Blandine Bonnamy, Florence Joly, Philippe Benech and Eric Barrey
    Citation: BMC Medical Genomics 2012 5:29
    Content type: Research article Published on:

  46. Transcriptomic studies in clinical research are essential tools for deciphering the functional elements of the genome and unraveling underlying disease mechanisms. Various technologies have been developed to d...

    Authors: Nalini Raghavachari, Jennifer Barb, Yanqin Yang, Poching Liu, Kimberly Woodhouse, Daniel Levy, Christopher J O‘Donnell, Peter J Munson and Gregory J Kato
    Citation: BMC Medical Genomics 2012 5:28
    Content type: Research article Published on:

  47. Asthma is a chronic inflammatory airway disease influenced by genetic and environmental factors that affects ~300 million people worldwide, leading to ~250,000 deaths annually. Glucocorticoids (GCs) are well-k...

    Authors: Diego Diez, Susumu Goto, John V Fahy, David J Erle, Prescott G Woodruff, Åsa M Wheelock and Craig E Wheelock
    Citation: BMC Medical Genomics 2012 5:27
    Content type: Research article Published on:

  48. The noninvasive prenatal diagnosis procedures that are currently used to detect genetic diseases do not achieve desirable levels of sensitivity and specificity. Recently, fetal methylated DNA biomarkers in mat...

    Authors: Aihua Yin, Xiangzhong Zhang, Jing Wu, Li Du, Tianwen He and Xiaozhuang Zhang
    Citation: BMC Medical Genomics 2012 5:26
    Content type: Research article Published on:

  49. Abdominal aortic aneurysm (AAA) is a dilatation of the aorta affecting most frequently elderly men. Histologically AAAs are characterized by inflammation, vascular smooth muscle cell apoptosis, and extracellul...

    Authors: Matthew C Pahl, Kimberly Derr, Gabor Gäbel, Irene Hinterseher, James R Elmore, Charles M Schworer, Thomas C Peeler, David P Franklin, John L Gray, David J Carey, Gerard Tromp and Helena Kuivaniemi
    Citation: BMC Medical Genomics 2012 5:25
    Content type: Research article Published on:
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