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  1. Publicly available data repositories facilitate the sharing of an ever-increasing amount of microarray data. However, these datasets remain highly underutilized. Reutilizing the data could offer insights into ...

    Authors: Jessica D Tenenbaum, Michael G Walker, Paul J Utz and Atul J Butte

    Citation: BMC Medical Genomics 2008 1:51

    Content type: Technical advance

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  2. It has previously been shown that specific microdeletions and microduplications, many of which also associated with cognitive impairment (CI), can present with autism spectrum disorders (ASDs). Multiplex ligat...

    Authors: Guiqing Cai, Lisa Edelmann, Juliet E Goldsmith, Ninette Cohen, Alisa Nakamine, Jennifer G Reichert, Ellen J Hoffman, Danielle M Zurawiecki, Jeremy M Silverman, Eric Hollander, Latha Soorya, Evdokia Anagnostou, Catalina Betancur and Joseph D Buxbaum

    Citation: BMC Medical Genomics 2008 1:50

    Content type: Research article

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  3. Genistein is an isoflavonoid present in soybeans that exhibits anti-carcinogenic properties. The issue of genistein as a potential anti-cancer drug has been addressed in some papers, but comprehensive genomic ...

    Authors: Christian RA Regenbrecht, Marc Jung, Hans Lehrach and James Adjaye

    Citation: BMC Medical Genomics 2008 1:49

    Content type: Research article

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  4. The etiology of many chronic diseases involves interactions between environmental factors and genes that modulate physiological processes. Understanding interactions between environmental chemicals and genes/p...

    Authors: Allan P Davis, Cynthia G Murphy, Michael C Rosenstein, Thomas C Wiegers and Carolyn J Mattingly

    Citation: BMC Medical Genomics 2008 1:48

    Content type: Research article

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  5. Hypermethylation of promoter CpG islands with associated loss of gene expression, and hypomethylation of CpG-rich repetitive elements that may destabilize the genome are common events in most, if not all, epit...

    Authors: George S Watts, Bernard W Futscher, Nicholas Holtan, Koen DeGeest, Frederick E Domann and Stephen L Rose

    Citation: BMC Medical Genomics 2008 1:47

    Content type: Research article

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  6. Inflammation is a hallmark of many human diseases. Elucidating the mechanisms underlying systemic inflammation has long been an important topic in basic and clinical research. When primary pathogenetic events ...

    Authors: Bor-Sen Chen, Shih-Kuang Yang, Chung-Yu Lan and Yung-Jen Chuang

    Citation: BMC Medical Genomics 2008 1:46

    Content type: Research article

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  7. While BMPR2 mutation strongly predisposes to pulmonary arterial hypertension (PAH), only 20% of mutation carriers develop clinical disease. This finding suggests that modifier genes contribute to FPAH clinical...

    Authors: James West, Joy Cogan, Mark Geraci, Linda Robinson, John Newman, John A Phillips, Kirk Lane, Barbara Meyrick and Jim Loyd

    Citation: BMC Medical Genomics 2008 1:45

    Content type: Research article

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  8. Late-onset Alzheimer's disease (LOAD) is an age related neurodegenerative disease with a high prevalence that places major demands on healthcare resources in societies with increasingly aged populations. The o...

    Authors: Richard Abraham, Valentina Moskvina, Rebecca Sims, Paul Hollingworth, Angharad Morgan, Lyudmila Georgieva, Kimberley Dowzell, Sven Cichon, Axel M Hillmer, Michael C O'Donovan, Julie Williams, Michael J Owen and George Kirov

    Citation: BMC Medical Genomics 2008 1:44

    Content type: Research article

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  9. The regulatory subunit of cAMP-dependent protein kinase (PKA) exists in two isoforms, RI and RII, which distinguish the PKA isozymes, type I (PKA-I) and type II (PKA-II). Evidence obtained from a variety of di...

    Authors: Chris Cheadle, Maria Nesterova, Tonya Watkins, Kathleen C Barnes, John C Hall, Antony Rosen, Kevin G Becker and Yoon S Cho-Chung

    Citation: BMC Medical Genomics 2008 1:43

    Content type: Research article

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  10. The number of gene expression studies in the public domain is rapidly increasing, representing a highly valuable resource. However, dataset-specific bias precludes meta-analysis at the raw transcript level, ev...

    Authors: Andrew H Sims, Graeme J Smethurst, Yvonne Hey, Michal J Okoniewski, Stuart D Pepper, Anthony Howell, Crispin J Miller and Robert B Clarke

    Citation: BMC Medical Genomics 2008 1:42

    Content type: Research article

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  11. The rexinoid bexarotene (LGD1069, Targretin) is a highly selective retinoid × receptor (RXR) agonist that inhibits the growth of pre-malignant and malignant breast cells. Bexarotene was shown to suppress the d...

    Authors: Martin C Abba, Yuhui Hu, Carla C Levy, Sally Gaddis, Frances S Kittrell, Yun Zhang, Jamal Hill, Reid P Bissonnette, Daniel Medina, Powel H Brown and C Marcelo Aldaz

    Citation: BMC Medical Genomics 2008 1:40

    Content type: Research article

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  12. Numerous studies have used microarrays to identify gene signatures for predicting cancer patient clinical outcome and responses to chemotherapy. However, the potential impact of gene expression profiling in ca...

    Authors: Jiangang Liu, Andrew Campen, Shuguang Huang, Sheng-Bin Peng, Xiang Ye, Mathew Palakal, A Keith Dunker, Yuni Xia and Shuyu Li

    Citation: BMC Medical Genomics 2008 1:39

    Content type: Research article

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  13. Strong epidemiologic evidence correlates tobacco use with a variety of serious adverse health effects, but the biological mechanisms that produce these effects remain elusive.

    Authors: Peter C Charles, Brian D Alder, Eleanor G Hilliard, Jonathan C Schisler, Robert E Lineberger, Joel S Parker, Sabeen Mapara, Samuel S Wu, Andrea Portbury, Cam Patterson and George A Stouffer

    Citation: BMC Medical Genomics 2008 1:38

    Content type: Research article

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  14. The role of microRNAs (miRNAs) in multiple myeloma (MM) has yet to be fully elucidated. To identify miRNAs that are potentially deregulated in MM, we investigated those mapping within transcription units, base...

    Authors: Domenica Ronchetti, Marta Lionetti, Laura Mosca, Luca Agnelli, Adrian Andronache, Sonia Fabris, Giorgio Lambertenghi Deliliers and Antonino Neri

    Citation: BMC Medical Genomics 2008 1:37

    Content type: Research article

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  15. Neuroblastic tumours (NBTs) represent a heterogeneous spectrum of neoplastic diseases associated with multiple genetic alterations. Structural and numerical chromosomal changes are frequent and are predictive ...

    Authors: Cinzia Lavarino, Idoia Garcia, Carlos Mackintosh, Nai-Kong V Cheung, Gema Domenech, José Ríos, Noelia Perez, Eva Rodríguez, Carmen de Torres, William L Gerald, Esperanza Tuset, Sandra Acosta, Helena Beleta, Enrique de Álava and Jaume Mora

    Citation: BMC Medical Genomics 2008 1:36

    Content type: Research article

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  16. Methotrexate is one of the earliest cytotoxic drugs used in cancer therapy, and despite the isolation of multiple other folate antagonists, methotrexate maintains its significant role as a treatment for differ...

    Authors: Elisabet Selga, Cristina Morales, Véronique Noé, Miguel A Peinado and Carlos J Ciudad

    Citation: BMC Medical Genomics 2008 1:35

    Content type: Research article

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  17. Expression microarray analyses of epithelial ovarian cancer (EOC) cell lines may be exploited to elucidate genetic and epigenetic events important in this disease. A possible variable is the influence of growt...

    Authors: Neal AL Cody, Magdalena Zietarska, Ali Filali-Mouhim, Diane M Provencher, Anne-Marie Mes-Masson and Patricia N Tonin

    Citation: BMC Medical Genomics 2008 1:34

    Content type: Research article

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  18. Recent work, using both cell culture model systems and tumour derived cell lines, suggests that the differential recruitment into polysomes of mRNA populations may be sufficient to initiate and maintain tumour...

    Authors: Raphael Genolet, Tanguy Araud, Laetitia Maillard, Pascale Jaquier-Gubler and Joseph Curran

    Citation: BMC Medical Genomics 2008 1:33

    Content type: Technical advance

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  19. Mechanisms underlying the malignant development in bladder cancer are still not well understood. Lipolysis stimulated lipoprotein receptor (LSR) has previously been found to be upregulated by P53. Furthermore,...

    Authors: Malene Herbsleb, Karin Birkenkamp-Demtroder, Thomas Thykjaer, Carsten Wiuf, Anne-Mette K Hein, Torben F Ørntoft and Lars Dyrskjøt

    Citation: BMC Medical Genomics 2008 1:31

    Content type: Research article

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  20. In periodontitis, treatment aimed at controlling the periodontal biofilm infection results in a resolution of the clinical and histological signs of inflammation. Although the cell types found in periodontal t...

    Authors: Thomas Beikler, Ulrike Peters, Karola Prior, Martin Eisenacher and Thomas F Flemmig

    Citation: BMC Medical Genomics 2008 1:30

    Content type: Research article

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  21. Persistent infection by high risk HPV types (e.g. HPV-16, -18, -31, and -45) is the main risk factor for development of cervical intraepithelial neoplasia and cervical cancer. Tumor necrosis factor (TNF) is a ...

    Authors: Lara Termini, Enrique Boccardo, Gustavo H Esteves, Roberto Hirata Jr, Waleska K Martins, Anna Estela L Colo, E Jordão Neves, Luisa Lina Villa and Luiz FL Reis

    Citation: BMC Medical Genomics 2008 1:29

    Content type: Research article

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  22. Vaginal atrophy (VA) is the thinning of the vaginal epithelial lining, typically the result of lowered estrogen levels during menopause. Some of the consequences of VA include increased susceptibility to bacte...

    Authors: Scott A Jelinsky, Sung E Choe, Judy S Crabtree, Monette M Cotreau, Ewa Wilson, Kathryn Saraf, Andrew J Dorner, Eugene L Brown, Bryan J Peano, Xiaochun Zhang, Richard C Winneker and Heather A Harris

    Citation: BMC Medical Genomics 2008 1:27

    Content type: Research article

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  23. Despite advances in the understanding of diabetic retinopathy, the nature and time course of molecular changes in the retina with diabetes are incompletely described. This study characterized the functional an...

    Authors: Robert M Brucklacher, Kruti M Patel, Heather D VanGuilder, Georgina V Bixler, Alistair J Barber, David A Antonetti, Cheng-Mao Lin, Kathryn F LaNoue, Thomas W Gardner, Sarah K Bronson and Willard M Freeman

    Citation: BMC Medical Genomics 2008 1:26

    Content type: Research article

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  24. Lung cancer with EGFR mutation was shown to be a specific clinical entity. In order to better understand the biology behind this disease we used a genome wide characterization of loss of heterozygosity and amp...

    Authors: Hélène Blons, Karine Pallier, Delphine Le Corre, Claire Danel, Maxime Tremblay-Gravel, Claude Houdayer, Elizabeth Fabre-Guillevin, Marc Riquet, Philippe Dessen and Pierre Laurent-Puig

    Citation: BMC Medical Genomics 2008 1:25

    Content type: Research article

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  25. Variants in numerous genes are thought to affect the success or failure of cancer chemotherapy. Interindividual variability can result from genes involved in drug metabolism and transport, drug targets (recept...

    Authors: Zunyan Dai, Audrey C Papp, Danxin Wang, Heather Hampel and Wolfgang Sadee

    Citation: BMC Medical Genomics 2008 1:24

    Content type: Technical advance

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  26. Angiotensin I-converting enzyme (ACE) plays an important role in cardiovascular homeostasis. There is evidence from different ethnic groups that circulating ACE levels are influenced by a quantitative trait lo...

    Authors: Colin A McKenzie, Xiaofeng Zhu, Terrence E Forrester, Amy Luke, Adebowale A Adeyemo, Nourdine Bouzekri and Richard S Cooper

    Citation: BMC Medical Genomics 2008 1:23

    Content type: Research article

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  27. Recent genome-wide association (GWA) studies have provided compelling evidence of association between genetic variants and common complex diseases. These studies have made use of cases and controls almost excl...

    Authors: Sean Myles, Dan Davison, Jeffrey Barrett, Mark Stoneking and Nic Timpson

    Citation: BMC Medical Genomics 2008 1:22

    Content type: Research article

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  28. The P-glycoprotein, encoded by the ABCB1 gene, is expressed in human endothelial and mesangial cells, which contribute to control renal plasma flow and glomerular filtration rate. We investigated the association ...

    Authors: Murielle Bochud, Chin B Eap, Marc Maillard, Toby Johnson, Peter Vollenweider, Pascal Bovet, Robert C Elston, Sven Bergmann, Jacques S Beckmann, Dawn M Waterworth, Vincent Mooser, Anne Gabriel and Michel Burnier

    Citation: BMC Medical Genomics 2008 1:21

    Content type: Research article

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  29. Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide. At present no reliable biomarkers are available to guide the management of this condition. Microarray technology may allow...

    Authors: Austin Tanney, Gavin R Oliver, Vadim Farztdinov, Richard D Kennedy, Jude M Mulligan, Ciaran E Fulton, Susan M Farragher, John K Field, Patrick G Johnston, D Paul Harkin, Vitali Proutski and Karl A Mulligan

    Citation: BMC Medical Genomics 2008 1:20

    Content type: Research article

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  30. The major histocompatibility complex (MHC) is essential for human immunity and is highly associated with common diseases, including cancer. While the genetics of the MHC has been studied intensively for many d...

    Authors: Eleni M Tomazou, Vardhman K Rakyan, Gregory Lefebvre, Robert Andrews, Peter Ellis, David K Jackson, Cordelia Langford, Matthew D Francis, Liselotte Bäckdahl, Marcos Miretti, Penny Coggill, Diego Ottaviani, Denise Sheer, Adele Murrell and Stephan Beck

    Citation: BMC Medical Genomics 2008 1:19

    Content type: Research article

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  31. Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects ~8 million annually culminating in ~2 million deaths. Moreover, about one third of the population is latently infected, 10% of which ...

    Authors: Anat Zvi, Naomi Ariel, John Fulkerson, Jerald C Sadoff and Avigdor Shafferman

    Citation: BMC Medical Genomics 2008 1:18

    Content type: Research article

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  32. The aberrant transcription in cancer of genes normally associated with embryonic tissue differentiation at various organ sites may be a hallmark of tumour progression. For example, neuroendocrine differentiati...

    Authors: Maria Vias, Charlie E Massie, Philip East, Helen Scott, Anne Warren, Zongxiang Zhou, Alexander Yu Nikitin, David E Neal and Ian G Mills

    Citation: BMC Medical Genomics 2008 1:17

    Content type: Research article

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  33. Atherosclerotic peripheral arterial disease (PAD) affects 8–10 million people in the United States and is associated with a marked impairment in quality of life and an increased risk of cardiovascular events. ...

    Authors: Sharon LR Kardia, M Todd Greene, Eric Boerwinkle, Stephen T Turner and Iftikhar J Kullo

    Citation: BMC Medical Genomics 2008 1:16

    Content type: Research article

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  34. DNA amplifications alter gene dosage in cancer genomes by multiplying the gene copy number. Amplifications are quintessential in a considerable number of advanced cancers of various anatomical locations. The a...

    Authors: Samuel Myllykangas, Jarkko Tikka, Tom Böhling, Sakari Knuutila and Jaakko Hollmén

    Citation: BMC Medical Genomics 2008 1:15

    Content type: Research article

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  35. Obesity and insulin resistance are two major risk factors underlying the metabolic syndrome. The development of these metabolic disorders is frequently studied, but mainly in liver, skeletal muscle, and adipos...

    Authors: Nicole JW de Wit, Hanneke Bosch-Vermeulen, Philip J de Groot, Guido JEJ Hooiveld, Mechteld M Grootte Bromhaar, Jenny Jansen, Michael Müller and Roelof van der Meer

    Citation: BMC Medical Genomics 2008 1:14

    Content type: Research article

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  36. The process of malignant transformation, progression and metastasis of melanoma is poorly understood. Gene expression profiling of human cancer has allowed for a unique insight into the genes that are involved...

    Authors: Adam I Riker, Steven A Enkemann, Oystein Fodstad, Suhu Liu, Suping Ren, Christopher Morris, Yaguang Xi, Paul Howell, Brandon Metge, Rajeev S Samant, Lalita A Shevde, Wenbin Li, Steven Eschrich, Adil Daud, Jingfang Ju and Jaime Matta

    Citation: BMC Medical Genomics 2008 1:13

    Content type: Research article

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  37. With the introduction of increasingly powerful mass spectrometry (MS) techniques for clinical research, several recent large-scale MS proteomics studies have sought to characterize the entire human plasma prot...

    Authors: Sudipto Saha, Scott H Harrison, Changyu Shen, Haixu Tang, Predrag Radivojac, Randy J Arnold, Xiang Zhang and Jake Yue Chen

    Citation: BMC Medical Genomics 2008 1:12

    Content type: Database

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  38. Dupuytren's contracture (DC) is the most common inherited connective tissue disease of humans and is hypothesized to be associated with aberrant wound healing of the palmar fascia. Fibroblasts and myofibroblas...

    Authors: Latha Satish, William A LaFramboise, David B O'Gorman, Sandra Johnson, Benjamin Janto, Bing Siang Gan, Mark E Baratz, Fen Z Hu, J Christopher Post, Garth D Ehrlich and Sandeep Kathju

    Citation: BMC Medical Genomics 2008 1:10

    Content type: Research article

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  39. Molecular characterization of breast and other cancers by gene expression profiling has corroborated existing classifications and revealed novel subtypes. Most profiling studies are based on fresh frozen (FF) ...

    Authors: Andrea Oberli, Vlad Popovici, Mauro Delorenzi, Anna Baltzer, Janine Antonov, Sybille Matthey, Stefan Aebi, Hans Jörg Altermatt and Rolf Jaggi

    Citation: BMC Medical Genomics 2008 1:9

    Content type: Technical advance

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  40. Pterostilbene, a naturally occurring phenolic compound produced by agronomically important plant genera such as Vitis and Vacciunium, is a phytoalexin exhibiting potent antifungal activity. Additionally, recent s...

    Authors: Zhiqiang Pan, Ameeta K Agarwal, Tao Xu, Qin Feng, Scott R Baerson, Stephen O Duke and Agnes M Rimando

    Citation: BMC Medical Genomics 2008 1:7

    Content type: Research article

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  41. Midkine is a heparin-binding growth factor that is over-expressed in various human cancers and plays important roles in cell transformation, growth, survival, migration, and angiogenesis. However, little is kn...

    Authors: Zongbing You, Ying Dong, Xiangtian Kong, Laurel A Beckett, Regina Gandour-Edwards and Jonathan Melamed

    Citation: BMC Medical Genomics 2008 1:6

    Content type: Research article

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  42. Although the PBS-IIc SELDI-TOF MS apparatus has been extensively used in the search for better biomarkers, issues have been raised concerning the semi-quantitative nature of the technique and its reproducibili...

    Authors: Marie-Christine W Gast, Judith YMN Engwegen, Jan HM Schellens and Jos H Beijnen

    Citation: BMC Medical Genomics 2008 1:4

    Content type: Research article

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  43. Urothelial carcinoma (UC) is characterized by nonrandom chromosomal aberrations, varying from one or a few changes in early-stage and low-grade tumors, to highly rearranged karyotypes in muscle-invasive lesion...

    Authors: Markus Heidenblad, David Lindgren, Tord Jonson, Fredrik Liedberg, Srinivas Veerla, Gunilla Chebil, Sigurdur Gudjonsson, Åke Borg, Wiking Månsson and Mattias Höglund

    Citation: BMC Medical Genomics 2008 1:3

    Content type: Research article

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  44. The early detection of prostate cancer has resulted in an increase in the number of patients with localized prostate cancer and has paralleled the reported reduction in prostate cancer mortality. The increased...

    Authors: Timothy J McDonnell, Nikhil S Chari, Jeong Hee Cho-Vega, Patricia Troncoso, Xuemei Wang, Carlos E Bueso-Ramos, Kevin Coombes, Shawn Brisbay, Remigio Lopez, George Prendergast, Christopher Logothetis and Kim-Anh Do

    Citation: BMC Medical Genomics 2008 1:1

    Content type: Research article

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2019 Journal Metrics

Announcement

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.