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Table 2 Comparative analysis of gene expression changes in primary and metastatic melanoma.

From: The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis

Gene Symbol Relative increase in gene expression Gene Symbol Relative decrease in gene expression
  MIS to Thin Thin To IM IM to Thick Thick to Met MIS to Met   MIS to Thin Thin To IM IM to Thick Thick to Met MIS to Met
MAGEA2 <2 8.6 9.4 3.1 30.7 SPRR1A <2 <2 <2 129.4 239.3
MAGEA3 <2 8.1 10.7 3 83.8 SPRR1B <2 <2 <2 52.8 100.8
MAGE A6 <2 7.1 9.8 2.7 103 KRT16 <2 <2 <2 68.3 195.5
MAGEA1,2 <2 2.5 8.9 2.6 81.5 KRT17 <2 2.6 <2 27.4 57.6
MAGE A1 <2 <2 11.1 <2 25.4 KRT6B <2 <2 <2 39.7 100.9
MAGE A5 <2 2.2 3.9 <2 11.7 AQP3 <2 <2 3.2 6.1 43.2
MMP19 5.4 <2 <2 <2 7.4 CD24 <2 <2 2 4.4 18.7
PDGFRL 22.3 3.6 <2 <2 6.3 FLG <2 <2 3 24.1 140
C16orf34 5.4 <2 <2 <2 18.5 IVL <2 2.2 <2 13.9 84.1
CTH 3.9 <2 <2 <2 8.8 KLK7 <2 <2 6.5 8.9 128
GPR19 4.2 <2 3 <2 23.9 LGALS7 <2 <2 3.4 17.3 109.3
SPP1 <2 13.1 <2 <2 44.9 LOR <2 <2 2.4 22.6 120.4
HOXA10 <2 3.3 <2 <2 3.8 RAB25 <2 <2 3.3 10.3 88.4
MMP14 <2 3.6 <2 2.1 9 SFN <2 <2 <2 10.6 24.2
AKT3 <2 <2 7.5 <2 14.3 C19orf33 3.1 <2 4.6 13.3 220.3
BCL2A1 <2 2.2 4.8 <2 18.7 ASAH3 <2 <2 25.9 <2 60
BIRC5 <2 <2 3.7 <2 3.4 KRT15 <2 <2 27.1 2.2 104.9
BUB1 <2 <2 9.4 <2 10.8 ELOVL4 <2 2.3 14.7 <2 41.9
CDC45L <2 <2 13 <2 9.1 GATA3 2.5 <2 14.3 <2 23.5
CDK2 <2 <2 4.8 <2 8.4 MUC15 <2 2.2 11.9 <2 25
CSAG2 <2 <2 19.6 2.6 54.5 SCEL <2 <2 28.8 <2 71.8
DUSP4 2 <2 5.7 <2 12.5 TP73L <2 <2 5.5 3.4 41.2
DUSP6 <2 <2 3.7 <2 10.5 RORA <2 <2 6.2 2.2 26.6
GYPC <2 <2 12.2 <2 14.2 POU2F3 <2 <2 13.9 2.2 73.9
HEY1 <2 <2 5.7 <2 9.3 ICEBERG <2 2.7 6.7 4.5 32.3
KIFC1 <2 <2 10.4 <2 16 CASZ1 <2 4.8 2.8 <2 12.3
PEG10 <2 2.4 4.1 <2 11.3 HR <2 3.7 <2 <2 7.7
RASGRF1 <2 <2 5.1 <2 9.9 TMPRSS4 8.7 <2 <2 3.1 42
RGS20 3.4 <2 9.2 <2 34.3 STAR 4.9 <2 <2 <2 11.1
SLC16A4 <2 <2 4.4 <2 26.4 ST7L 4.3 <2 3.6 <2 8.4
SOX5 <2 <2 12.3 <2 19.8 LTB4R 4 <2 2.3 <2 9.9
TRIM51 <2 3.1 15.9 <2 63.6 HAS3 4.9 <2 <2 2.5 16.6
TYMS <2 <2 3.6 <2 4.7 FGFR3 3.9 <2 3.2 <2 7.6
  1. NOTE: All annotated genes listed above with a < 2 indicates that any difference between tumors for each comparative analysis was less than 2-fold. Underlined numbers indicate the greatest change in gene expression across varying PCM tumor thickness for each gene. Abbreviations: MIS, melanoma-in-situ, Thin, thin melanomas < 1.0 mm in Breslow's thickness, I.M., intermediate thickness between 1–4 mm, with thick melanomas > 4 mm. PCM, primary cutaneous melanoma.