Skip to main content

Table 1 Obesity- and/or insulin resistance-associated genes and their expression in the small intestine of C57BL/6J mice fed a high-fat diet.

From: The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice

Gene name (symbol)

Previous association with obesity and/or insulin resistance (ref.)

 

Transcriptional regulation in small intestine on a HF diet

Nuclear receptors & target genes

   

ATP-binding cassette, sub-family A, 1 (Abca1)

-/- mice; IR â–²

[45]

↓ P, M, D

Farnesoid X-activated receptor (Fxr, Nr1h4)

-/- mice; IR â–²

[46, 47]

minimal regulation, but target genes:

↑ P, M; ↓ D

Liver X receptor (LXRα/β, Nr1h2/3)

-/- mice; obesity & IR â–¼

[48]

minimal regulation, but target genes:

cholesterol metabolism ↓ P, M, D

fatty acid metabolism ↑ P, M

Peroxisome proliferator activated receptor α (Pparα)

-/- mice; obesity â–², IR â–¼

[28, 29]

minimal regulation, but target genes:

↑ P, M, D

Peroxisome proliferator activated receptor δ (Pparδ)

-/- mice; IR â–²

[32]

↓, M

Peroxisome proliferator activated receptor γ (Pparγ)

-/+ mice; IR â–¼

Agonists (TZDs) used as anti-diabetic agents

[49, 50]

minimal regulation

Pparγ, coactivator 1α (Pgc1α)

-/- mice; obesity â–², IR â–¼

[51]

↓ M

Stearoyl-Coenzyme A desaturase 1 (Scd1)

-/- mice; obesity & IR â–¼

[33, 34]

↑ P, M, D

Sterol regulatory element binding factor 1 (Srebf1)

-/- mice; obesity â–¼

[35]

↑ P

Small heterodimer partner (Shp, Nr0b2)

-/- mice; obesity & IR â–¼

[36]

↑ P, M

Secreted (signaling) proteins

   

Angiopoietin-like 4 (Angptl4)

Tg mice; obesity â–¼, IR â–²

Suppression by gut microbiota promotes triglyceride storage

[6]

↑ P, M, D

Fibroblast growth factor 15 (Fgf15)

Injection of Fgf15; glucose tolerance â–²

[41]

↓ D

Glucagon-like peptide-1 (Glp1)

High plasma levels; IR â–¼

[12, 13]

↑ (slightly) M

Gastric inhibitory polypeptide (Gip)

High plasma levels; IR â–¼

[13]

↑ (slightly) D

Insulin-like growth factor binding protein 3 (Igfbp3)

Tg mice; IR â–²

[42]

↑ P, M

Interleukin 18 (Il18)

-/- mice; obesity & IR â–²

[37]

↓ P, M

Macrophage migration inhibitory factor (Mif)

High plasma levels; obesity & IR â–²

[39]

↑ M, D

  1. -/- mice: null mice, +/- mice: heterozygous mice, Tg mice: transgenic mice, IR: insulin resistance, P, M, D: proximal, middle, distal part of the small intestine, ▲: prone to, ▼: resistant to, ↑: up-regulated expression, ↓: down-regulated expression. In bold: dietary-fat induced molecular changes in the small intestine that point in the same direction as data from previous null- and transgenic mouse studies regarding development of metabolic syndrome.
Back to article page

BMC Medical Genomics

ISSN: 1755-8794

Contact us