Classification of human cancers based on DNA copy number amplification modeling

BMC Medical Genomics

Table 1 Hypothesis testing of proportions of labile chromosomal sites within the amplification patterns.

Labile chromosomal site	Proportion in patterns	Proportion in amplification pattern borders	Proportion inside amplification patterns	p-value
Fragile sites	0.3086	0.3693	-	0.0069*
	0.3086	-	0.2975	0.8448
Dark chromosome bands	0.3739	0.3182	-	0.9896
	0.3739	-	0.4301	0.0000*
Light chromosome bands	0.4629	0.5114	-	0.0405*
	0.4629	-	0.4122	1.0000
Telomere bands	0.1217	0.2330	-	0.0000
	0.1217	-	0.0000	1.0000**
Centromere bands	0.1187	0.1477	-	0.0378*
	0.1187	-	0.1147	0.7481
Variable bands	0.0445	0.0227	-	0.9388
	0.0445	-	0.0430	0.7154

The proportion of chromosomal attributes in patterns in general is compared to the proportion of chromosomal attributes on the borders of the amplification patterns as well as inside amplification patterns (excluding the borders). Statistical significance of the difference in proportions was determined using permutation tests and p-values are marked in the table. Significant findings are marked with an asterisk.
*Statistically significant findings (p < 0.05).
**By definition, telomeres can not be located inside the amplification patterns and therefore this test could not yield any significant findings.

ISSN: 1755-8794