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Table 1 Shows regions of focal amplifications analyzed by Xba1 50000 SNPs array (Affymetrix) that are significantly linked to EGFR mutated tumors.

From: Genome wide SNP comparative analysis between EGFR and KRAS mutated NSCLC and characterization of two models of oncogenic cooperation in non-small cell lung carcinoma

Base position start Base position end Chromosome Band Genes within the region NAME Known functions
46489396 47088012 14q21.3 MAMDC1 MAM DOMAIN CONTAINING1 MAM domain containing protein
11727815 13456320 7p21.3-7p21.2 TMEM106B Hypothetical transmembrane protein unknown
    AK027618 Weakly similar to neurogenic locus notch3 protein unknown
    AK075525 Weakly similar to UROMODULIN PRECURSOR unknown
    BC075797 cDNA clone MGC:87550 unknown
    CR592342 cDNA clone MGC:87550  
    SCIN SCINDERIN Organization of microfilament network
    ARL4 ADP-ribosylation factor-like 4A ADP-ribosylation factor family of GTP-binding protein
11120441 11377580 7p21.3 PHF14 HD finger protein 14 isoform 1 unknown
    BC040327 Homo sapiens cDNA clone IMAGE:4830466 unknown
18006698 20386036 7p21.1-7p15.3 PRPS1L1 PRPS1L1 Phosphoribosyl pyrophosphate synthetase 1-like
    HDAC9 Histone deacetylase 9 isoform 4 Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA
    TWIST1 TWIST1 The protein encoded by this gene is a bHLH transcription factor. Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation.
    FERD3L Nephew of atonal 3 N-TWIST basic (helix-loop-helix protein)
    TWISTNB TWIST neighbor DNA-directed RNA polymerase I subunit RPA43-transcription
    MGC42090 Hypothetical protein LOC256130 unknown
    7A5 Putative binding protein 7a5 unknown
    ITGB8 integrin, beta 8 precursor This gene is a member of the integrin beta chain family. Integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation.