Genome wide SNP comparative analysis between EGFR and KRAS mutated NSCLC and characterization of two models of oncogenic cooperation in non-small cell lung carcinoma

Hélène Blons; Karine Pallier; Delphine Le Corre; Claire Danel; Maxime Tremblay-Gravel; Claude Houdayer; Elizabeth Fabre-Guillevin; Marc Riquet; Philippe Dessen; Pierre Laurent-Puig

doi:10.1186/1755-8794-1-25

Table 1 Shows regions of focal amplifications analyzed by Xba1 50000 SNPs array (Affymetrix) that are significantly linked to EGFR mutated tumors.

From: Genome wide SNP comparative analysis between EGFR and KRAS mutated NSCLC and characterization of two models of oncogenic cooperation in non-small cell lung carcinoma

Base position start	Base position end	Chromosome Band	Genes within the region	NAME	Known functions
46489396	47088012	14q21.3	MAMDC1	MAM DOMAIN CONTAINING1	MAM domain containing protein
11727815	13456320	7p21.3-7p21.2	TMEM106B	Hypothetical transmembrane protein	unknown
			AK027618	Weakly similar to neurogenic locus notch3 protein	unknown
			AK075525	Weakly similar to UROMODULIN PRECURSOR	unknown
			BC075797	cDNA clone MGC:87550	unknown
			CR592342	cDNA clone MGC:87550
			SCIN	SCINDERIN	Organization of microfilament network
			ARL4	ADP-ribosylation factor-like 4A	ADP-ribosylation factor family of GTP-binding protein
11120441	11377580	7p21.3	PHF14	HD finger protein 14 isoform 1	unknown
			BC040327	Homo sapiens cDNA clone IMAGE:4830466	unknown
18006698	20386036	7p21.1-7p15.3	PRPS1L1	PRPS1L1	Phosphoribosyl pyrophosphate synthetase 1-like
			HDAC9	Histone deacetylase 9 isoform 4	Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA
			TWIST1	TWIST1	The protein encoded by this gene is a bHLH transcription factor. Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation.
			FERD3L	Nephew of atonal 3	N-TWIST basic (helix-loop-helix protein)
			TWISTNB	TWIST neighbor	DNA-directed RNA polymerase I subunit RPA43-transcription
			MGC42090	Hypothetical protein LOC256130	unknown
			7A5	Putative binding protein 7a5	unknown
			ITGB8	integrin, beta 8 precursor	This gene is a member of the integrin beta chain family. Integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation.

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