Table 1 Shows regions of focal amplifications analyzed by Xba1 50000 SNPs array (Affymetrix) that are significantly linked to EGFR mutated tumors.
Base position start | Base position end | Chromosome Band | Genes within the region | NAME | Known functions |
|---|---|---|---|---|---|
46489396 | 47088012 | 14q21.3 | MAMDC1 | MAM DOMAIN CONTAINING1 | MAM domain containing protein |
11727815 | 13456320 | 7p21.3-7p21.2 | TMEM106B | Hypothetical transmembrane protein | unknown |
AK027618 | Weakly similar to neurogenic locus notch3 protein | unknown | |||
AK075525 | Weakly similar to UROMODULIN PRECURSOR | unknown | |||
BC075797 | cDNA clone MGC:87550 | unknown | |||
CR592342 | cDNA clone MGC:87550 | ||||
SCIN | SCINDERIN | Organization of microfilament network | |||
ARL4 | ADP-ribosylation factor-like 4A | ADP-ribosylation factor family of GTP-binding protein | |||
11120441 | 11377580 | 7p21.3 | PHF14 | HD finger protein 14 isoform 1 | unknown |
BC040327 | Homo sapiens cDNA clone IMAGE:4830466 | unknown | |||
18006698 | 20386036 | 7p21.1-7p15.3 | PRPS1L1 | PRPS1L1 | Phosphoribosyl pyrophosphate synthetase 1-like |
HDAC9 | Histone deacetylase 9 isoform 4 | Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA | |||
TWIST1 | TWIST1 | The protein encoded by this gene is a bHLH transcription factor. Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. | |||
FERD3L | Nephew of atonal 3 | N-TWIST basic (helix-loop-helix protein) | |||
TWISTNB | TWIST neighbor | DNA-directed RNA polymerase I subunit RPA43-transcription | |||
MGC42090 | Hypothetical protein LOC256130 | unknown | |||
7A5 | Putative binding protein 7a5 | unknown | |||
ITGB8 | integrin, beta 8 precursor | This gene is a member of the integrin beta chain family. Integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. |