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Table 3 Top coregulated clusters of genes

From: Molecular analysis of the vaginal response to estrogens in the ovariectomized rat and postmenopausal woman

   Human cluster Rat cluster
Gene Symbol Gene Description t* q** t* q**
TXNIP thioredoxin interacting protein -5.5 0.0002 -12.5 0
RBP1 retinol binding protein 1, cellular -4.2 0.0021 -15.1 0
IGFBP3 insulin-like growth factor binding protein 3 -4.6 0.0007 -10.0 0
IFITM3 interferon induced transmembrane protein 3 (1–8 U) -5.2 0.0002 -9.0 0
DHRS8 dehydrogenase/reductase (SDR family) member 8 -5.4 0.0002 -5.6 0
LDHB lactate dehydrogenase B -4.6 0.0006 -6.1 0
LAPTM4B lysosomal associated protein transmembrane 4 beta -4.5 0.0008 -8.3 0
MUC1 mucin 1, transmembrane -5.7 0.0002 -5.2 0
SFRP2 secreted frizzled-related protein 2 -5.4 0.0002 -5.8 0
IFITM1 interferon induced transmembrane protein 1 (9–27) -4.2 0.0019 -6.8 0
CD74 CD74 antigen -4.3 0.0015 -8.2 0
LR8 LR8 protein -3.6 0.0076 -7.6 0
B2M beta-2-microglobulin -4.1 0.0025 -8.0 0
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B -4.8 0.0006 -6.1 0
PRKACB protein kinase, cAMP-dependent, catalytic, beta -5.2 0.0003 -4.2 0
TSPAN3 tetraspanin 3 -4.4 0.0014 -6.5 0
PROM1 prominin 1 -2.8 0.0452 -9.0 0
TMC4 transmembrane channel-like 4 -3.8 0.0045 -8.0 0
ITM2C integral membrane protein 2C -3.0 0.0343 -8.0 0
DHRS3 dehydrogenase/reductase (SDR family) member 3 -3.6 0.0079 -5.9 0
ITM2B integral membrane protein 2B -2.5 0.0778 -9.6 0
VIM vimentin -2.7 0.0503 -9.6 0
NPC2 Niemann-Pick disease, type C2 -4.0 0.0029 -6.5 0
AXL AXL receptor tyrosine kinase -4.4 0.0012 -4.9 0
HLA-DRA major histocompatibility complex, class II, DR alpha -3.3 0.0153 -8.5 0
EEF1A1 Eukaryotic translation elongation factor 1 alpha 1 -4.1 0.0023 -5.1 0
FOXQ1 forkhead box Q1 -3.5 0.0116 -6.1 0
IFNGR1 interferon gamma receptor 1 -2.5 0.0745 -8.5 0
IGFBP7 insulin-like growth factor binding protein 7 -3.4 0.0138 -7.2 0
RNASET2 ribonuclease T2 -3.0 0.032 -7.4 0
SAT spermidine/spermine N1-acetyltransferase -3.7 0.0073 -7.6 0
BHLHB3 basic helix-loop-helix domain containing, class B, 3 -5.8 0.0002 -2.3 0.04
SELENBP1 selenium binding protein 1 -4.0 0.0033 -4.8 0
C11orf8 chromosome 11 open reading frame 8 -5.0 0.0004 -3.6 0
LSP1 lymphocyte-specific protein 1 -4.9 0.0004 -2.9 0
KRT19 keratin 19 -3.3 0.0 -10.1 0
  1. t* Average t-statistic
  2. q** Average q-value