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Table 2 "Global functional analysis" conducted using Ingenuity Pathway Analysis.

From: Increased cell motility and invasion upon knockdown of lipolysis stimulated lipoprotein receptor (LSR) in SW780 bladder cancer cells

Time after transfection siRNA Category Process Annotation Significance
18 h TP53 Cell Death cell death of tumor cell lines 5.96E-09
   Organismal Survival survival of mammalia 9.59E-09
   Cell Death cell death of lung cancer cell lines 3.72E-08
   Organismal Survival survival of mice 9.84E-08
   Cellular Growth and Proliferation colony formation of eukaryotic cells 1.48E-07
  LSR1 Cancer proliferation of tumor cell lines 3.78E-07
   DNA Replication, Recombination, and Repair synthesis of DNA 4.61E-07
   Cell Death apoptosis of cell lines 1.67E-06
   Cancer cell death of tumor cell lines 1.95E-06
   Organismal Survival survival of mammalia 2.29E-06
  LSR2 Cancer growth of tumor cell lines 2.11E-07
   Cellular Growth and Proliferation growth of cell lines 3.14E-07
   Cancer proliferation of tumor cell lines 1.38E-06
   Cardiovascular System Development and Function development of blood vessel 1.78E-06
   Cellular Growth and Proliferation growth of eukaryotic cells 2.85E-06
  TP53+LSR1 Cellular Growth and Proliferation colony formation of eukaryotic cells 5.07E-10
   Organismal Survival survival of mammalia 8.79E-09
   Cellular Growth and Proliferation colony formation of cell lines 1.11E-08
   Cell Death cell death of cell lines 3.66E-08
   Cancer colony formation of tumor cell lines 1.11E-07
48 h TP53 Cell-To-Cell Signaling and Interaction activation of eukaryotic cells 1.17E-10
   Organismal Survival survival of rodents 1.74E-09
   Cellular Growth and Proliferation proliferation of cell lines 1.29E-08
   Cellular Growth and Proliferation growth of central nervous system cells 1.76E-08
   Cellular Growth and Proliferation colony formation of cells 3.72E-08
  LSR1 Cellular Movement cell movement 3.26E-12
   Cellular Movement invasion of eukaryotic cells 2.31E-11
   Cellular Movement invasion of cell lines 1.61E-09
   Cellular Movement cell movement of cell lines 3.84E-09
   Cellular Movement cell movement of endothelial cells 4.24E-09
  LSR2 Cellular Movement cell movement 2.72E-15
   Cellular Growth and Proliferation growth of tumor cell lines 4.45E-12
   Cellular Movement cell movement of eukaryotic cells 4.54E-12
   Cell-To-Cell Signaling and Interaction adhesion of cells 4.78E-12
   Cellular Movement cell movement of cell lines 7.54E-12
  TP53+LSR1 Renal and Urological Disease renal and urological disorder of rodents 3.87E-08
   Renal and Urological Disease renal and urological disorder of rats 1.05E-07
   Cancer growth of tumor cell lines 1.99E-07
   Cellular Growth and Proliferation colony formation of eukaryotic cells 5.94E-07
   Cellular Growth and Proliferation colony formation of cell lines 1.18E-06
72 h TP53 Tissue Development development of tissue 5.91E-08
   Tissue Development angiogenesis of chorioallantoic membrane 8.76E-08
   Renal and Urological Disease renal and urological disorder of rodents 1.01E-07
   Cancer angiogenesis of tumor 1.82E-07
   Cellular Movement cell movement 1.99E-07
  LSR1 Cellular Movement cell movement 8.99E-11
   Cellular Movement migration of eukaryotic cells 2.41E-09
   Cellular Movement cell movement of eukaryotic cells 2.46E-09
   Cellular Movement cell movement of cell lines 5.27E-09
   Cellular Movement migration of tumor cell lines 1.72E-08
  LSR2 Cellular Movement cell movement 5.60E-15
   Cellular Movement cell movement of eukaryotic cells 2.46E-13
   Cellular Movement migration of eukaryotic cells 7.57E-13
   Cellular Growth and Proliferation growth of tumor cell lines 5.66E-12
   Tissue Development formation of tissue 8.77E-12
  TP53+LSR1 Cellular Movement migration of eukaryotic cells 4.19E-10
   Cellular Movement cell movement 8.74E-10
   Cellular Movement cell movement of eukaryotic cells 1.57E-09
   Cancer angiogenesis of tumor 6.86E-09
   Renal and Urological Disease renal and urological disorder of rodents 8.15E-09
  1. The list includes the annotation of the differentially expressed genes upon knockdown. The likelihood that the association between a set of differentially expressed genes and a given function was due to chance was calculated using the right-tailed Fisher's exact test. The biological functions or processes annotated to affected genes are listed according to their significance.