Hyperclustering of cotinine responsive genes. A. The 109 genes identified by SAM and GSA analysis in subjects with high versus low plasma cotinine levels were analyzed by hyperclustering. Clusters (top) were created by incorporating gene expression data with their corresponding TRANSFAC and Gene Ontology (GO) categories. Genes are represented in columns. Individual subject expression profiles (which clustered into 2 groups, high and low cotinine) and TRANSFAC categories are represented in rows and the relative expression of the genes is reflected as indicated in the color scale (upper right). Gene membership in GO categories (also represented in rows) is indicated by Carolina blue. B. Enlargement of the five functional groups identified by hyperclustering (bottom). The corresponding TRANSFAC and GO categories are indicated by groups A and B-H, respectively (see Table 4 for detailed category information).