Tobacco use induces anti-apoptotic, proliferative patterns of gene expression in circulating leukocytes of Caucasian males

Table 3 Summary of GSA.

Gene Set Pathway	Description	P-value
DEATHPATHWAY (c2:161)[71]	Genes involved in signaling via Fas and DR3, 4, and 5.	< 0.0001
METASTASIS_ADENOCARC_DN (c2:1553)[72]	Genes involved in metastasis of solid tumors.	< 0.0001
DAC_IFN_BLADDER_UP (c2:1304)[73]	Interferon responsive genes upregulated by DAC treatment.	< 0.0001

Top 3 gene sets (71 total genes) identified by GSA comparing gene expression profiles of subjects with high plasma cotinine versus low plasma cotinine, showing the names of differentially expressed gene sets as defined by Gene Set Enrichment Analysis [70] with accompanying p-value and FDR.

ISSN: 1755-8794