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Table 2 Types of curated arsenic-gene interactions

From: The Comparative Toxicogenomics Database facilitates identification and understanding of chemical-gene-disease associations: arsenic as a case study

Arsenic-to-Gene Molecular Interactions Genes1
mRNA up-regulated 810
mRNA down-regulated 652
Protein up-regulated 97
mRNA/protein altered2 82
Protein activity 78
Protein down-regulated 49
Protein phosphorylation 39
Protein cleavage/degradation 14
Protein localization 14
Protein secretion 8
Promoter methylation 7
Protein metabolism 6
mRNA/protein stabilization 4
Gene mutagenesis 4
Gene-to-Arsenic Molecular Interactions Genes 1
Arsenic resistance/susceptibility 43
Arsenic transport 5
Arsenic metabolism 5
Protein binds arsenic 5
  1. 1 Some genes are counted in more than one interaction category
  2. 2 Molecule (mRNA or protein) and/or direction (up or down-regulation) were not specified