Table 6 Cancers associated with arsenic-interacting genes

Breast

49

AKAP12; AKT1; ATM; BCL2; BCL2A1; BIRC5; BRCA1; BRCA2; CASP8; CCL20; CHEK2; CXCL2; CXCL3; CYP19A1; CYP1A1; CYP1B1; EGFR; ERBB2; ESR1; ETS2; FGFR2; FOS; FST; HMOX1; HRAS; IL1B; IL6; IL8; JUN; KRAS; NFKBIA; NR2F1; NR2F6: PDGFA; PIK3CA; PIM1; PTEN; PTGS2; RAD51; RGS2; SLC22A18; SNAI2; SYNJ2; TANK; TFPI2; TFRC; TNF; TP53; TYMS

Stomach

42

ALDH1A3; AURKB; BDNF; BIRC2; BIRC5; BNIP3; CASP8; CASP10; CAV1; CDH1; CDKN1A; CDKN2A; CDKN2D; CHFR; CTSL; EEF1A2; ERBB2; F2R; FGFR2; FST; FYN; HMOX1; IGFBP3; IGFBP7; IL1B; IL1RN; IL6R; IRF1; KRAS; MT2A; MYC; NOS3; PIK3CA; PLAU; RBP1; RGS2: RORA; SERPINE1; SOD2; SPRR2A; TFAP2C; TIMP3

Leukemia

23

AKT1; AQP9; BAD; BCL2; BCR; BIRC2; BIRC3; CCND1; CD44; CEBPA; CFLAR; ETV6; F3; HOXD4; ITGAM; ITGB2; KIT; NSD1; PML: PTEN; PTPN11; RARA; TFRC

Nervous system

19

BRCA2; CTNNB1; EGF; ERBB2; HGF; IL1B; IL8; MET; MGMT; MMP2; MMP9; MYCN; NCOR1; MNE1; PMS2; PPARG; PTEN; TFRC; VEGFA

Lung

18

AREG; BIRC5; CASP8; EGFR; ERBB2; ESR1; GCLC; HMOX1; KRAS; MAP3K8; MAPK14; PHLDA2; PIK3CA; RASSF1; SLC22A18; TFRC; TGFA; TP53

Colon

17

AKT1; CASP8; CHEK2; EGFR; EP300; ERBB2; MLH1; MSH6; ODC1; PIK3CA; PMS2; PTGS2; SMAD7; TFRC; TGFBR2; TP53; TYMS

Bladder

15

BIRC3; CDKN2A; EGFR; ESR1; HRAS; KRAS; MT1A; MT2A; MT3; PRSS3; RASSF1; RB1; SRC; TFRC; TRP53

Skin

15

CDKN2A; DDB2; ERCC2; ERCC3; ERCC4; ERCC5; GYPA; HRAS; KRT10; MDM2; PMS2; TP53; XPA; XPC; XRCC3

Prostate

11

AR; BRCA2; CHEK2; ERBB2; ESR1; ICAM1; IL8; MMP9; MT2A; PTEN; VEGFA

Liver

10

AFP; CASP8; CTNNB1; ESR1; MAPK14; MET; PIK3CA; RARA; TP53; TRIM24

Ovary

10

AKT1; BIRC5; BRCA1; BRCA2; CYP19A1; EGFR; FST; MAPK1; MAPK3; PIK3CA

Esophagus

8

CASP8; MT1; MT1G; PTGS2; RNF6; SNAI2; TGFBR2; TRP53

Lymphoma

7

BCL2; BHMT; CASP10; MLH1; MYC; TFRC; TYMS

Head and neck

6

AREG; EGFR; MAPK1; MAPK3; TGFA; TNFRSF10B

Thyroid

5

HRAS; MINPP1; PTEN; TP53; TRIM24

Kidney

3

CYP1A1; MET; OGG1

Pancreas

3

BRCA2; KRAS; TP53