Figure 5

Kaplan-Meier survival analysis comparing results from Rosenwald and EPSA. A. Kaplan-Meier survival curve from Rosenwald, in which GC type diverges from the other subtypes (p < 0.0001), but AB and Type III do not diverge significantly (n = 240) [8]. B-D. Kaplan-Meier curves for activated B cell-like and type III DLBCL (n = 125) separated based on degree of correlation with LPS, CD40, and CPG signatures respectively. Patients in these plots are only those in the lower two curves from A; the GC subtype was excluded from analysis. Survival curves for the most- and least-correlated tertiles (n = 125/3 ≈ 42 each) diverge significantly, in contrast to that of the AB vs. type III distinction. Cox proportional-hazards p-value is shown for the subset of the 125 AB and type III patients.