Figure 3

Association between in vitro signatures and clinical outcome (Dataset 1). (A): Association between time course signature and DFS: Median DFS: 9 versus 18 months for the unfavorable and favorable groups respectively (p = 0.005, log-rank test), Hazard Ratio 2.3 (95% C.I. 1.3 – 4.2). (B): Association between time course signature and OS: Median OS: 41 months versus not yet reached for the unfavorable versus favorable group (p = 0.043, log-rank test), Hazard Ratio 2.1 (95% C.I. 1 – 4.5). (C): Association between pathway signature and DFS: Median DFS: 11 versus 17 months for the unfavorable versus favorable group, (p = 0.011, log-rank test), Hazard Ratio 2.1 (95% C.I. 1.2 – 4). (D): Association between pathway signature and OS: Median OS: 34 months versus not yet reached for the unfavorable versus favorable group (p = 0.002, log-rank test), Hazard Ratio 3.1 (95% C.I. 1.5 – 6.6).