Table 4 Selected genes of the NRF2, cytokine response and NF-kB signaling pathways upregulated in patients with unfavorable DFS and OS

Oxidative stress response via Nrf2

< 0.0001

MAFF

< 0.0001

NRF2 (NFE2L2)

< 0.0001

CRYZ

< 0.001

CREB1

0.015

Cytokine and Inflammatory Response

< 0.0001

IL-6

0.005

IL-8

0.013

IL-15

0.0005

NF-kB signaling pathway

0.0002

NF-kB1

< 0.0001

IL1-R1

0.003

CHUK

0.002

RELA

0.005