Table 2 Plasma concentrations of sterols and sterol to plasma-cholesterol ratio of homozygous and heterozygous FH patients and controls.
From: Monocytes of patients with familial hypercholesterolemia show alterations in cholesterol metabolism
homozygous FH (n = 5) | heterozygous FH (n = 5) | Controls (n = 8) | ||||
|---|---|---|---|---|---|---|
plasma conc. | sterol: Cholesterol | plasma conc. | sterol: Cholesterol | plasma conc. | sterol: Cholesterol | |
Cholestanol (mg/dl) | 0.608 ± 0.075 (***) | 1,60*10-3 : 1 | 0.442 ± 0.062 (*) | 1,73*10-3 : 1 | 0.278 ± 0.038 | 1,59*10-3 : 1 |
Lathosterol (mg/dl) | 0.725 ± 0.226 | 1,78*10-3 : 1 | 0.563 ± 0.182 | 1,85*10-3 : 1 | 0.335 ± 0.121 | 1,61*10-3 : 1 |
Campesterol (mg/dl) | 0.692 ± 0.17 (**) | 1,77*10-3 : 1 | 0.651 ± 0.243 (*) | 2.58*10-3 : 1 | 0.267 ± 0.031 | 1.40*10-3 : 1 |
Campestanol (μg/dl) | 4.773 ± 1.096 (**) | 1,23*10-5 : 1 | 5.237 ± 1.402 (**) | 2.09*10-5 : 1 | 2.151 ± 0.253 | 1.37*10-5 : 1 |
Stigmasterol (μg/dl) | 24.805 ± 7.533 (**) | 6.54*10-5 : 1 | 19.163 ± 6.081 (*) | 7.79*10-5 : 1 | 7.772 ± 1.84 | 4.25*10-5 : 1 |
Sitosterol (mg/dl) | 0.522 ± 0.103 (**) | 1.37*10-3 : 1 | 0.519 ± 0.161 (*) | 2.08*10-3 : 1 | 0.184 ± 0.035 | 1.06*10-3 : 1 |
Sitostanol (μg/dl) | 8.597 ± 2.603 (*) | 2.13*10-5 : 1 | 7.206 ± 2.261 (*) | 2.76*10-5 : 1 | 2.933 ± 0.625 | 1.96*10-5 : 1 |
Brassicosterol (μg/dl) | 84.004 ± 17.864 (**) | 2.18*10-4 : 1 | 80.706 ± 26.213 (*) | 3.15*10-4 : 1 | 29.173 ± 2.612 | 1.88*10-4 : 1 |
Lanosterol (μg/dl) | 39.812 ± 8.347 | 1.01*10-4 : 1 (**) | 34.568 ± 12.712 | 1.23*10-4 : 1 | 31.123 ± 5.523 | 1.79*10-4 : 1 |
Desmosterol (mg/dl) | 0.359 ± 0.045 (**) | 9.37*10-4 : 1 | 0.254 ± 0.046 | 9.54*10-4 : 1 | 0.167 ± 0.034 | 9.62*10-4 : 1 |
24OH-Cholesterol (ng/ml) | 87.820 ± 18.094 (*) | 2.26*10-7 : 1 | 74.078 ± 9.541 | 2.90*10-7 : 1 | 50.585 ± 9.936 | 3.02*10-7 : 1 |
27OH-Cholesterol (ng/ml) | 196.463 ± 27.528 (**) | 5.12*10-7 : 1 | 179.638 ± 19. 015 (*) | 6.98*10-7 : 1 | 49.95 ± 9.533 | 7.75*10-7 : 1 |
7αOH-Cholesterol (ng/ml) | 142.908 ± 49.165 (*) | 3.95*10-7 : 1 | 63.429 ± 10.802 | 2.43*10-7 : 1 | 47.363 8.812 | 3.02*10-7 : 1 |
Cholesterol (mg/dl) | 385,748 ± 50.41 (***) | 260.55 ± 22.070 (*) | 165.669 ± 31.263 | |||