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Table 2 Plasma concentrations of sterols and sterol to plasma-cholesterol ratio of homozygous and heterozygous FH patients and controls.

From: Monocytes of patients with familial hypercholesterolemia show alterations in cholesterol metabolism

  homozygous FH (n = 5) heterozygous FH (n = 5) Controls (n = 8)
  plasma conc. sterol: Cholesterol plasma conc. sterol: Cholesterol plasma conc. sterol: Cholesterol
Cholestanol (mg/dl) 0.608 ± 0.075 (***) 1,60*10-3 : 1 0.442 ± 0.062 (*) 1,73*10-3 : 1 0.278 ± 0.038 1,59*10-3 : 1
Lathosterol (mg/dl) 0.725 ± 0.226 1,78*10-3 : 1 0.563 ± 0.182 1,85*10-3 : 1 0.335 ± 0.121 1,61*10-3 : 1
Campesterol (mg/dl) 0.692 ± 0.17 (**) 1,77*10-3 : 1 0.651 ± 0.243 (*) 2.58*10-3 : 1 0.267 ± 0.031 1.40*10-3 : 1
Campestanol (μg/dl) 4.773 ± 1.096 (**) 1,23*10-5 : 1 5.237 ± 1.402 (**) 2.09*10-5 : 1 2.151 ± 0.253 1.37*10-5 : 1
Stigmasterol (μg/dl) 24.805 ± 7.533 (**) 6.54*10-5 : 1 19.163 ± 6.081 (*) 7.79*10-5 : 1 7.772 ± 1.84 4.25*10-5 : 1
Sitosterol (mg/dl) 0.522 ± 0.103 (**) 1.37*10-3 : 1 0.519 ± 0.161 (*) 2.08*10-3 : 1 0.184 ± 0.035 1.06*10-3 : 1
Sitostanol (μg/dl) 8.597 ± 2.603 (*) 2.13*10-5 : 1 7.206 ± 2.261 (*) 2.76*10-5 : 1 2.933 ± 0.625 1.96*10-5 : 1
Brassicosterol (μg/dl) 84.004 ± 17.864 (**) 2.18*10-4 : 1 80.706 ± 26.213 (*) 3.15*10-4 : 1 29.173 ± 2.612 1.88*10-4 : 1
Lanosterol (μg/dl) 39.812 ± 8.347 1.01*10-4 : 1 (**) 34.568 ± 12.712 1.23*10-4 : 1 31.123 ± 5.523 1.79*10-4 : 1
Desmosterol (mg/dl) 0.359 ± 0.045 (**) 9.37*10-4 : 1 0.254 ± 0.046 9.54*10-4 : 1 0.167 ± 0.034 9.62*10-4 : 1
24OH-Cholesterol (ng/ml) 87.820 ± 18.094 (*) 2.26*10-7 : 1 74.078 ± 9.541 2.90*10-7 : 1 50.585 ± 9.936 3.02*10-7 : 1
27OH-Cholesterol (ng/ml) 196.463 ± 27.528 (**) 5.12*10-7 : 1 179.638 ± 19. 015 (*) 6.98*10-7 : 1 49.95 ± 9.533 7.75*10-7 : 1
7αOH-Cholesterol (ng/ml) 142.908 ± 49.165 (*) 3.95*10-7 : 1 63.429 ± 10.802 2.43*10-7 : 1 47.363 8.812 3.02*10-7 : 1
Cholesterol (mg/dl) 385,748 ± 50.41 (***)   260.55 ± 22.070 (*)   165.669 ± 31.263  
  1. Values are means ± SD. FH, familial hypercholesterolemia.