Table 3 Functional cluster analysis of differentially regulated genes in monocytes between FH individuals and controls.
From: Monocytes of patients with familial hypercholesterolemia show alterations in cholesterol metabolism
Welch T-Test (p < 0.05, Benjamini Hochberg Testing Correction FDR = 0.05) | Functional GO cluster | Genes | Group Enrichment Score |
|---|---|---|---|
2,318 transcripts regulated | protein transport, establishment of protein localization, intracellular protein transport | 130 | 7.62 |
clathrin coated vesicle, trans Golgi network transport vesicle, Golgi associated vesicle membrane, transport vesicle membrane | 15 | 2.86 | |
vacuole, lysosome, lytic vacuole | 37 | 2.42 | |
regulation of JNK activity activation of JNK activity,, positive activation of JNK activity, activation of MAPK activity | 14 | 2.32 | |
clathrin coated endocytotic vesicle, AP-2 adaptor complex, endocytotic vesicle membrane | 4 | 2.00 |