Figure 6

Functional effects and associations between candidates and benchmarks. Left panel, network of transcriptional perturbations mediated by SNPs at gene loci. Nodes represent SNP/gene loci of the 50 top-ranked candidates (Table 1) or of benchmarks, and edges represent the direction of the effect on gene expression, as shown in the inset. To avoid bias, we excluded those SNPs that are not annotated in the original data set of Dixon and colleagues [38]. Right panels, network results of the analysis of 100 randomly chosen sets of 50 genes and the same benchmarks (histograms and curves) compared to the observed values in the left panel (vertical arrows), for connected nodes (top) or edges (bottom).