Table 3 List of genes selected from microarrays analysis comparing normal mucosa matched tumour colon tissue. The different expression in tumoural tissue was showed.
From: Promoter methylation correlates with reduced NDRG2expression in advanced colon tumour
Function/category | Gene | Accession no. | Microarray Data | Gene description | |
|---|---|---|---|---|---|
| Â | Â | Â | P value | Expression | Â |
Insulin Receptor Signaling | SGK1 | NM_005627.1 | 0.059 | down | Serum glucocorticoid regulated kinase (SGK) |
Transport | CLCA4 | NM_012128.2 | 0.052 | down | chloride channel, calcium activated, family member 4 |
Transport | SLC26A3/DRA | NM_000111.1 | 0.044 | down | solute carrier family 26, member 3 (SLC26A3) |
Transport | AQP8 | NM_001169.1 | 0.052 | down | aquaporin 8 |
Transport | SCNN1B | NM_000336.1 | 0.046 | down | sodium channel, nonvoltage-gated 1, beta (S. Liddle) |
Transport (ATP binding) | ABCA8 | NM_007168.1 | 0.040 | down | ATP-binding cassette, sub-family A (ABC1), member 8 |
Protein transport | STX12 | AI816243 | 0.051 | down | syntaxin 12 |
Receptor activity (mineralcorticoid) | NR3C2 | NM_000901.1 | 0.049 | down | nuclear receptor subfamily 3, group C, member 2 |
Cell cycle (proliferation) | MXI1 | NM_005962.1 | 0.053 | down | MAX-interacting protein 1 (MXI1) |
Cell cycle (differentiation) | NDRG2 | NM_016250.1 | 0.039 | down | N-myc downstream-regulated gene 2 |
Prostaglandin metabolism | HPGD | J05594.1 | 0.050 | down | hydroxyprostaglandin dehydrogenase 15-(NAD) |
Prostaglandin and leukotriene Metabolism | PRDX6 | NM_004905.1 | 0.050 | down | peroxidase, acidic calcium-independent phospholipase A2 |
Signal tansduction | SGK2 | NM_016276.3 | 0.038 | down | serumglucocorticoid regulated kinase (SGK) |
Transcription factors | FOXM1 | NM_021953.1 | 0.046 | up | forkhead box M1 (FOXM1) |
Transcription factors | GTF2IRD1 | NM_016328.1 | 0.046 | up | GTF2I repeat domain-containing 1 (GTF2IRD1) |
Transcription factor | SOX9 | NM_000346.1 | 0.045 | up | Sex determining region Y-box 9 |
ATP-binding/proteins folding | HSPH1 | BG403660 | 0.043 | up | heat shock 105 kD (HSP105B) |
Transport solute carrier | SLC12A2 | NM_001046 | 0.048 | up | solute carrier family 12 |
Cell cycle (proliferation) | TPX2 | NM_012112.1 | 0.044 | up | restricted expressed proliferation associated protein |
Cell cycle (progression) | UBE2C | NM_007019.1 | 0.050 | up | ubiquitin carrier protein E2-C (UBCH10) |
Cell cycle (proliferation) | CSE1L/CAS | NM_001316 | 0.052 | up | CSE1 chromosome segregation 1-like (yeast) |
Signal Transduction | CCNB1 | Hs.23960 | 0.048 | up | cyclin B1 |
Focal adhesion | NEBL | NM_006393.1 | 0.038 | up | nebulette protein (NEBL, actin-binding Z-disc protein) |
Replication and repair | RFC3 | BC000149 | 0.049 | up | replication factor C (activator 1) 3 (38 kD) |