Table 1 Species and Compound Conserved Genes

Energetics

Aldoa

11674

1.36

2.04

1.34

1.75

Sustained

Atp5b

11947

1.70

1.85

1.67

1.69

Sustained

Atp5g1

11951

3.77

2.57

2.86

1.88

Sustained

Ckb

12709

2.72

2.92

1.42

2.04

Mid

Cox7b

20463

0.28

0.49

0.75

0.57

Sustained

Cycs

13063

4.69

3.72

4.22

3.11

Sustained

Ldha

16828

2.60

2.46

2.66

2.20

Sustained

Pgk1

18655

3.77

3.25

2.46

2.93

Sustained

Slc25a4

11739

2.02

1.94

1.53

1.94

Mid

Slc25a5

11740

5.32

3.17

4.31

3.09

Sustained

Txnl2

30926

1.96

2.35

1.45

1.90

Mid/Sustained

Chaperone & Protein Folding

Cct7

12468

2.76

2.71

2.18

2.08

Sustained

Hsp90aa

15519

2.65

1.47

3.21

2.69

Mid

Hspa5

14828

4.44

2.35

6.72

2.32

Sustained

Hspd1

15510

3.76

2.97

4.06

2.52

Mid

Hspe1

15528

3.64

3.67

3.43

3.08

Mid

Cell Structure

Dynll1

56455

2.33

2.26

1.67

1.73

Sustained

Krt13

16663

2.36

3.48

2.79

3.68

Sustained

Krt8

16691

1.78

2.95

1.30

3.10

Sustained

Serpinh1

12406

3.71

2.80

3.51

2.05

Mid

Tubb2c

227613

1.35

3.07

3.03

2.68

Mid

Cell Signaling

App

11820

0.40

0.39

0.48

0.51

Sustained

Cd24a

12484

2.23

4.00

5.00

3.74

Late

Dcn

13179

0.35

0.38

0.50

0.49

Sustained

Igf1

16000

4.50

7.16

4.40

5.92

Sustained

Sepp1

20363

0.26

0.25

0.19

0.31

Mid

Transcription & NA Processing

Atf4

11911

4.42

3.27

2.96

2.00

Sustained

Cnot4

53621

3.16

6.33

2.88

5.91

Sustained

Fos

14281

6.38

40.25

4.08

7.86

Early

Hnrpab

15384

3.31

3.17

2.28

2.18

Sustained

Hnrpu

51810

2.22

1.82

1.71

1.49

Sustained

Translation & Protein Turnover

Eif1

20918

1.57

2.37

1.41

1.71

Mid

Eif2s2

67204

3.50

1.87

1.82

2.38

Sustained

Psma5

26442

1.64

1.99

1.42

1.70

Mid

Psmb5

19173

3.11

2.31

2.33

1.90

Mid

Uncategorized or Other

Armet

315989

9.77

3.67

2.21

3.11

Sustained

C3

12266

3.62

9.27

5.36

4.85

Late

Car3

12350

0.06

0.11

0.12

0.31

Late

Cst3

13010

0.72

0.34

0.61

0.35

Sustained

Hba-a1

15122

0.25

0.40

0.41

0.49

Late

Itm2b

16432

0.52

0.21

0.48

0.35

Mid

Ly6e

17069

1.90

2.49

1.96

1.38

Early/Late

Mgp

17313

0.22

0.40

0.38

0.51

Sustained

Ran

19384

3.23

4.25

3.68

3.19

Mid

Txn1

22166

1.51

2.10

1.64

1.72

Mid