Table 3 Top hubs differentially activated in the DI network
From: Network analysis of human glaucomatous optic nerve head astrocytes
network hubs | hub type | edges | in | out |
|---|---|---|---|---|
up-regulated hubs | ||||
SP1 | TF | 58 | 7 | 53 |
VDR | TF | 40 | 7 | 33 |
NF-kB | TF | 32 | 5 | 27 |
AP1 | TF | 21 | 2 | 19 |
AR | TF | 18 | 9 | 8 |
c-Fos | TF | 19 | 10 | 9 |
IGF-1 | growth factor | 17 | 7 | 10 |
c-Myb | TF | 14 | 7 | 7 |
STAT5B | TF | 13 | 9 | 4 |
HNF4-alpha | TF | 12 | 3 | 9 |
E2A | TF | 12 | 4 | 8 |
IL8 | cytokine | 11 | 10 | 1 |
MMP2 | protease | 10 | 8 | 2 |
down-regulated hubs | ||||
Interferon-gamma | growth factor | 19 | 3 | 16 |
STAT1 | TF | 17 | 6 | 11 |
c-Myb | TF | 6 | 0 | 6 |
PAI1 | ligand | 5 | 3 | 2 |