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Table 2 Functional profiling, negatively correlated genes

From: Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia

Functional group Gene set name No. of related sets Gene set size
(range) 		FDR q value
(range)
Neuron development Axon guidance 1 26 0.156
  Learning and/or memory 1 15 0.152
  Neuron development 10 47–246 0.074 – 0.165
  Cell development 7 36–425 0.059 – 0.192
  Chemotaxis 1 113 0.194
  Cell motility 4 94–219 0.151 – 0.167
  Cell adhesion 4 37–178 0.066 – 0.177
  Cell recognition 1 16–26 0.158
Neurotransmitter signalling Neuropeptide signalling pathway 1 72 0.008
  Glutamate signalling pathway 1 18 0.198
Receptor signalling Enzyme linked receptor protein signaling 2 128–176 0.046 – 0.047
  Regulation of G protein coupled receptor protein 1 25 0.194
Ion transport Cation transport 2 79–120 0.052 – 0.130
  Regulation of heart contraction 2 22–106 0.153 – 0.158
Protein processing Positive regulation of protein metabolism 1 51 0.061
  Positive regulation of protein kinase activity 1 56 0.149
  Proteoglycan biosynthesis 1 17 0.181
  Protein polymerization 1 34 0.199
Others Detection of stimulus 4 19–34 0.116–0.163
  Regulation of cell shape 1 30 0.076
  1. Functional gene sets are shown which show enrichment in the list of genes negatively correlated with a template showing peak expression in the 15–25 age range. Related gene sets as defined by leading edge analysis are grouped together in column 2 and the range of q values for these gene sets is indicated. Gene sets/groups of gene sets which are functionally associated but are composed of non-overlapping genes in the leading edge are indicated by headings in column 1. A full detailed list of significant gene sets can be found in Additional File 3.
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BMC Medical Genomics

ISSN: 1755-8794

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