Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia

BMC Medical Genomics

Table 2 Functional profiling, negatively correlated genes

Functional group	Gene set name	No. of related sets	Gene set size (range)	FDR q value (range)
Neuron development	Axon guidance	1	26	0.156
	Learning and/or memory	1	15	0.152
	Neuron development	10	47–246	0.074 – 0.165
	Cell development	7	36–425	0.059 – 0.192
	Chemotaxis	1	113	0.194
	Cell motility	4	94–219	0.151 – 0.167
	Cell adhesion	4	37–178	0.066 – 0.177
	Cell recognition	1	16–26	0.158
Neurotransmitter signalling	Neuropeptide signalling pathway	1	72	0.008
	Glutamate signalling pathway	1	18	0.198
Receptor signalling	Enzyme linked receptor protein signaling	2	128–176	0.046 – 0.047
	Regulation of G protein coupled receptor protein	1	25	0.194
Ion transport	Cation transport	2	79–120	0.052 – 0.130
	Regulation of heart contraction	2	22–106	0.153 – 0.158
Protein processing	Positive regulation of protein metabolism	1	51	0.061
	Positive regulation of protein kinase activity	1	56	0.149
	Proteoglycan biosynthesis	1	17	0.181
	Protein polymerization	1	34	0.199
Others	Detection of stimulus	4	19–34	0.116–0.163
	Regulation of cell shape	1	30	0.076

Functional gene sets are shown which show enrichment in the list of genes negatively correlated with a template showing peak expression in the 15–25 age range. Related gene sets as defined by leading edge analysis are grouped together in column 2 and the range of q values for these gene sets is indicated. Gene sets/groups of gene sets which are functionally associated but are composed of non-overlapping genes in the leading edge are indicated by headings in column 1. A full detailed list of significant gene sets can be found in Additional File 3.