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Table 2 Functional profiling, negatively correlated genes

From: Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia

Functional group

Gene set name

No. of related sets

Gene set size

(range)

FDR q value

(range)

Neuron development

Axon guidance

1

26

0.156

 

Learning and/or memory

1

15

0.152

 

Neuron development

10

47–246

0.074 – 0.165

 

Cell development

7

36–425

0.059 – 0.192

 

Chemotaxis

1

113

0.194

 

Cell motility

4

94–219

0.151 – 0.167

 

Cell adhesion

4

37–178

0.066 – 0.177

 

Cell recognition

1

16–26

0.158

Neurotransmitter signalling

Neuropeptide signalling pathway

1

72

0.008

 

Glutamate signalling pathway

1

18

0.198

Receptor signalling

Enzyme linked receptor protein signaling

2

128–176

0.046 – 0.047

 

Regulation of G protein coupled receptor protein

1

25

0.194

Ion transport

Cation transport

2

79–120

0.052 – 0.130

 

Regulation of heart contraction

2

22–106

0.153 – 0.158

Protein processing

Positive regulation of protein metabolism

1

51

0.061

 

Positive regulation of protein kinase activity

1

56

0.149

 

Proteoglycan biosynthesis

1

17

0.181

 

Protein polymerization

1

34

0.199

Others

Detection of stimulus

4

19–34

0.116–0.163

 

Regulation of cell shape

1

30

0.076

  1. Functional gene sets are shown which show enrichment in the list of genes negatively correlated with a template showing peak expression in the 15–25 age range. Related gene sets as defined by leading edge analysis are grouped together in column 2 and the range of q values for these gene sets is indicated. Gene sets/groups of gene sets which are functionally associated but are composed of non-overlapping genes in the leading edge are indicated by headings in column 1. A full detailed list of significant gene sets can be found in Additional File 3.