Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia

BMC Medical Genomics

Table 3 Myelination related genes showing expression changes during adolescence

Gene	Symbol	Correlation with 15–25 template		Change in SZ	Number of studies
		r	*Adjusted p-value*
Claudin 11	CLDN11	0.42	0.0613	Down	3 ^(2,4,6)
2',3'-cyclic nucleotide 3' phosphodiesterase	CNP	0.49	0.0258	Down	4 ^(2,3,4)
myelin associated glycoprotein	MAG	0.44	0.0496	Down	4 ^(1,2,3,4)
mal, T-cell differentiation protein	MAL	0.44	0.0471	Down	3 ^(1,3,5)
myelin basic protein	MBP	0.51	0.0201	Down	2 ^(5,6)
Myelin-associated oligodendrocytic basic protein	MOBP	0.35	0.1384	Down	2 ^(5,6)
myelin oligodendrocyte glycoprotein	MOG	0.49	0.0271	Down	2 ^(4,6)
plasma membrane proteolipid (plasmolipin)	PLLP	0.48	0.0285	Down	1 ⁽¹⁾
proteolipid protein 1	PLP1	0.46	0.0386	Down	2 ^(1,6)
myelin protein zero-like 1	MPZL1	-0.63	0.0063	Up	1 ⁽⁶⁾
aspartoacylase	ASPA	0.48	0.0298	Down	1 ⁽⁷⁾

Myelination related genes showing expression changes during adolescence and relevant findings from the schizophrenia literature are shown. Citations are indicated by a footnote in the final column as follows: 1 [46] 2. [47] 3. [48] 4. [49] 5[50] 6. [45] 7. [52]

ISSN: 1755-8794