Table 1 Genes differentially expressed between diabetic models and controls that map to regions conserved with human DN susceptibility loci.
GK vs WKY | STZ vs WKY | STZ vs GK | ||||||
|---|---|---|---|---|---|---|---|---|
Gene Symbol | Gene description | Genbank | TR | p-value | TR | p-value | TR | p-value |
Human 3q23-q29 | ||||||||
Bdh | 3-hydroxybutyrate dehydrogenase | NM_053995 | +1.3 | Ns | -1.2 | Ns | -1.6 | 0.007 |
Centb2 | Centaurin beta 2 | BM389190 | -1.4 | Ns | 1.0 | Ns | +1.3 | 0.047 |
Clcn2 | Chloride channel 2 | NM_017137 | +1.2 | Ns | -1.1 | Ns | -1.4 | 0.038 |
Cldn16 | Claudin 16 | NM_131905 | -1.1 | Ns | -1.6 | 0.002 | -1.4 | 0.01 |
Dgkg | Diacylglycerol kinase gamma | NM_013126 | +1.2 | Ns | +1.6 | 0.025 | +1.3 | Ns |
Dnajb11 | DnaJ (Hsp40) subfamily B11 | BI295873 | 1.0 | Ns | -1.3 | 0.043 | -1.3 | Ns |
Eif4g1 | Eukaryotic translation initiation factor | BC098868 | +1.1 | Ns | -1.2 | Ns | -1.4 | 0.011 |
Fad104 | FAD104 (predicted) | AI176320 | +1.3 | Ns | -1.3 | 0.05 | -1.7 | 5 × 10-4 |
Fam43a | Family with sequence similarity 43A | BE108405 | -1.1 | Ns | -1.7 | 0.017 | -1.5 | Ns |
Hrg | Histidine-rich glycoprotein | NM_133428 | -1.2 | Ns | +2.0 | 0.034 | +2.5 | 0.007 |
Mfn1 | Mitofusin 1 | AI169627 | 1.0 | Ns | +1.7 | 0.046 | +1.7 | 0.035 |
AA943135 | 1.0 | Ns | +1.5 | 0.018 | +1.5 | 0.009 | ||
Ncbp2 | Nuclear cap binding protein subunit 2 | BI282103 | +1.3 | Ns | -1.5 | 0.046 | -2 | 0.002 |
Pld1 | Phospholipase D1 | U69550 | -1.3 | Ns | -1.8 | 0.036 | -1.4 | Ns |
Pigx | Subunit of GPI-mannosyltransferase | AI172192 | +1.3 | Ns | 1.0 | Ns | -1.3 | 0.043 |
Rbp1 | Retinol binding protein 1 | NM_012733 | 1.0 | Ns | +2.3 | 3 × 10-4 | +2.2 | 3 × 10-4 |
Siat1 | Sialyltransferase 1 | M83143 | 1.0 | Ns | -1.6 | 0.002 | -1.6 | 0.001 |
Slc2a2 | Solute carrier family 2 member 2 (Glut2) | NM_012879 | +3.0 | 5 × 10-4 | +3.6 | 1 × 10-4 | +1.2 | Ns |
Ssr3 | Signal sequence receptor gamma | NM_031120 | -1.2 | Ns | +1.3 | Ns | +1.6 | 0.003 |
Zbed4 | Zinc finger, BED domain containing 4 | AI170289 | -1.1 | Ns | -1.3 | 0.046 | -1.2 | Ns |
--- | Similar to protein NP_079596 | AI412011 | +1.4 | Ns | -1.5 | 0.044 | -2.1 | 0.001 |
Human 7q32.3-q33 | ||||||||
Akr1b4 | Aldo-keto reductase family 1B4 | NM_012498 | 1.0 | Ns | +2.2 | Ns | +2.1 | 0.024 |
Akr1b8 | Aldo-keto reductase family 1B8 | NM_173136 | -6.2 | 6 × 10-5 | +1.4 | Ns | +8.5 | 8 × 10-6 |
Slc35b4 | Solute carrier family 35 member B4 | XM_216122 | +1.2 | Ns | -1.1 | Ns | -1.4 | 0.010 |
Human 18q12-q23 | ||||||||
Acaa2 | Acetyl-Coenzyme A acyltransferase 2 | NM_130433 | -1.6 | 0.041 | -1.3 | Ns | +1.2 | Ns |
Brunol4 | RNA binding protein bruno-like 4 | AW530502 | +1.1 | Ns | +1.3 | 0.036 | +1.2 | Ns |
Cndp1 | Carnosinase 1 | AI231438 | 1.0 | Ns | -3.4 | 3 × 10-5 | -3.5 | 8 × 10-6 |
Cndp2 | Carnosinase 2 | BI279729 | +1.1 | Ns | -1.3 | 0.042 | -1.4 | 0.01 |
G0S2 | Putative lymphocyte G0/G1 switch gene | AI406939 | +1.3 | Ns | -1.6 | Ns | -2.1 | 0.004 |
Mapk4 | Mitogen-activated protein kinase 4 | BG378232 | +1.3 | Ns | +1.5 | 0.023 | +1.2 | Ns |
Mep1b | meprin 1 beta (endopeptidase-2) | NM_013183 | 1.0 | Ns | -1.4 | 0.042 | -1.4 | 0.050 |
Pqlc1 | PQ loop repeat containing 1 | AI228284 | +1.6 | 0.044 | +1.7 | 0.011 | +1.1 | Ns |
Slc14a2 | Solute carrier family 14, member 2 | NM_019347 | -1.1 | Ns | +1.5 | 0.020 | +1.7 | 0.005 |
AF042167 | -1.1 | Ns | +1.4 | Ns | +1.6 | 0.035 | ||
Human 20p12.3-p13 | ||||||||
Cdc25b | Cell division cycle 25 homolog B | NM_133572 | +1.2 | Ns | +1.6 | 0.028 | +1.4 | Ns |
Prnp | Prion protein | NM_012631 | +1.6 | 0.029 | +1.1 | Ns | -1.5 | 0.030 |