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Table 1 Genes differentially expressed between diabetic models and controls that map to regions conserved with human DN susceptibility loci.

From: Functional annotations of diabetes nephropathy susceptibility loci through analysis of genome-wide renal gene expression in rat models of diabetes mellitus

    GK vs WKY STZ vs WKY STZ vs GK
Gene Symbol Gene description Genbank TR p-value TR p-value TR p-value
Human 3q23-q29
Bdh 3-hydroxybutyrate dehydrogenase NM_053995 +1.3 Ns -1.2 Ns -1.6 0.007
Centb2 Centaurin beta 2 BM389190 -1.4 Ns 1.0 Ns +1.3 0.047
Clcn2 Chloride channel 2 NM_017137 +1.2 Ns -1.1 Ns -1.4 0.038
Cldn16 Claudin 16 NM_131905 -1.1 Ns -1.6 0.002 -1.4 0.01
Dgkg Diacylglycerol kinase gamma NM_013126 +1.2 Ns +1.6 0.025 +1.3 Ns
Dnajb11 DnaJ (Hsp40) subfamily B11 BI295873 1.0 Ns -1.3 0.043 -1.3 Ns
Eif4g1 Eukaryotic translation initiation factor BC098868 +1.1 Ns -1.2 Ns -1.4 0.011
Fad104 FAD104 (predicted) AI176320 +1.3 Ns -1.3 0.05 -1.7 5 × 10-4
Fam43a Family with sequence similarity 43A BE108405 -1.1 Ns -1.7 0.017 -1.5 Ns
Hrg Histidine-rich glycoprotein NM_133428 -1.2 Ns +2.0 0.034 +2.5 0.007
Mfn1 Mitofusin 1 AI169627 1.0 Ns +1.7 0.046 +1.7 0.035
   AA943135 1.0 Ns +1.5 0.018 +1.5 0.009
Ncbp2 Nuclear cap binding protein subunit 2 BI282103 +1.3 Ns -1.5 0.046 -2 0.002
Pld1 Phospholipase D1 U69550 -1.3 Ns -1.8 0.036 -1.4 Ns
Pigx Subunit of GPI-mannosyltransferase AI172192 +1.3 Ns 1.0 Ns -1.3 0.043
Rbp1 Retinol binding protein 1 NM_012733 1.0 Ns +2.3 3 × 10-4 +2.2 3 × 10-4
Siat1 Sialyltransferase 1 M83143 1.0 Ns -1.6 0.002 -1.6 0.001
Slc2a2 Solute carrier family 2 member 2 (Glut2) NM_012879 +3.0 5 × 10-4 +3.6 1 × 10-4 +1.2 Ns
Ssr3 Signal sequence receptor gamma NM_031120 -1.2 Ns +1.3 Ns +1.6 0.003
Zbed4 Zinc finger, BED domain containing 4 AI170289 -1.1 Ns -1.3 0.046 -1.2 Ns
--- Similar to protein NP_079596 AI412011 +1.4 Ns -1.5 0.044 -2.1 0.001
Human 7q32.3-q33
Akr1b4 Aldo-keto reductase family 1B4 NM_012498 1.0 Ns +2.2 Ns +2.1 0.024
Akr1b8 Aldo-keto reductase family 1B8 NM_173136 -6.2 6 × 10-5 +1.4 Ns +8.5 8 × 10-6
Slc35b4 Solute carrier family 35 member B4 XM_216122 +1.2 Ns -1.1 Ns -1.4 0.010
Human 18q12-q23
Acaa2 Acetyl-Coenzyme A acyltransferase 2 NM_130433 -1.6 0.041 -1.3 Ns +1.2 Ns
Brunol4 RNA binding protein bruno-like 4 AW530502 +1.1 Ns +1.3 0.036 +1.2 Ns
Cndp1 Carnosinase 1 AI231438 1.0 Ns -3.4 3 × 10-5 -3.5 8 × 10-6
Cndp2 Carnosinase 2 BI279729 +1.1 Ns -1.3 0.042 -1.4 0.01
G0S2 Putative lymphocyte G0/G1 switch gene AI406939 +1.3 Ns -1.6 Ns -2.1 0.004
Mapk4 Mitogen-activated protein kinase 4 BG378232 +1.3 Ns +1.5 0.023 +1.2 Ns
Mep1b meprin 1 beta (endopeptidase-2) NM_013183 1.0 Ns -1.4 0.042 -1.4 0.050
Pqlc1 PQ loop repeat containing 1 AI228284 +1.6 0.044 +1.7 0.011 +1.1 Ns
Slc14a2 Solute carrier family 14, member 2 NM_019347 -1.1 Ns +1.5 0.020 +1.7 0.005
   AF042167 -1.1 Ns +1.4 Ns +1.6 0.035
Human 20p12.3-p13
Cdc25b Cell division cycle 25 homolog B NM_133572 +1.2 Ns +1.6 0.028 +1.4 Ns
Prnp Prion protein NM_012631 +1.6 0.029 +1.1 Ns -1.5 0.030
  1. Gene expression results from Affymetrix chip hybridizations are given as transcription ratio (TR). The list of genes in these regions represented on the Affymetrix chip and not differentially expressed is given in Additional file 7. Ns, not statistically significant differences.