Table 4 Oncogenes and tumor suppressor genes known to be associated with genomic changes in lung adenocarcinoma
Gene | CNA class | Cytoband | Deletion (%) | Amplification (%) |
|---|---|---|---|---|
FHIT | k = 3 (D) | 3p14.2 | 52.3 | 1.5 |
LIMD1 | k = 3 (D) | 3p21.3 | 34.4 | 1.5 |
hTERT | k = 7 (A) | 5p15.33 | 6.2 | 55.4 |
SKP2 | k = 7 (A) | 5p13 | 1.5 | 38.5 |
EGFR-1 | k = 7 (A) | 7p11.2 | 1.5 | 24.6 |
c-MET | k = 7 (A) | 7q31 | 7.7 | 23.1 |
c-MYC | k = 7 (A) | 8q24.12-13 | 4.6 | 36.9 |
CDKN2A | k = 3 (D) | 9p21 | 29.2 | 6.2 |
PTEN | k = 2 (D) | 10q23.3 | 18.5 | 5.2 |
CCND1 | k = 7 (A) | 11q13 | 6.2 | 21.5 |
RB | k = 3 (D) | 13q14.2 | 43.1 | 1.5 |
NKX2-1 | k = 7 (A) | 14q13.3 | 3.1 | 21.5 |
WWOX | k = 3 (D) | 16q23.3-24.1 | 33.8 | 6.2 |
P53 | k = 3 (D) | 17p13.1 | 36.9 | 4.6 |
E2F | k = 7 (A) | 20q11.2 | 3.1 | 23.1 |