Figure 4

Clorgyline treatment affected androgen signaling in E-CA-88 cells. (A) Expression changes of androgen-regulated genes identified by DePrimo et al. in response to clorgyline treatment. Red indicates higher expression in treated vs. control E-CA cells, and green indicates lower expression. Only changes ≥ 2-fold were displayed. The degree of color saturation corresponding to the fold change is shown at the bottom of the image. (B) Number of genes whose expression changed ≥ 2-fold after clorgyline treatment found in the list of androgen-regulated genes. Bars above the X-axis represent genes upregulated by clorgyline and bars below the X-axis downregulated. Asterisk indicates statistical significance by Chi-square test.