Table 2 Differentially expressed genes (>2 Fold) in response to HDACi in HT29 colon cancer cells.
| Â | Â | Â | HT29 | |
|---|---|---|---|---|
Accession # | Gene Symbol | Gene Name | Fold Change | P-Value |
Induced | Â | Â | LBH589 | |
NM_002305.2 | LGALS1 | Lectin, galactoside-binding soluble 1 | 5.22 | 3.0E-03 |
NM_003088.2 | FSCN1 | Fascin homolog 1, actin-bundling protein | 5.06 | 5.6E-03 |
NM_006262.3 | PRPH | Peripherin | 4.58 | 9.8E-04 |
NM_004223.3 | UBE2L6 | Ubiquitin-conjugating enzyme E2L 6 | 4.58 | 9.7E-04 |
NM_182908.3 | DHRS2 | Dehydrogenase/reductase member 2 | 4.37 | 5.5E-03 |
NM_006086.2 | TUBB3 | Tubulin, beta 3 | 4.06 | 1.4E-02 |
NM_002084.2 | GPX3 | Glutathione peroxidase 3 | 4.05 | 5.2E-03 |
NM_153247.1 | SLC29A4 | Solute carrier family 29, member 4 | 3.92 | 1.1E-03 |
NM_003283.3 | TNNT1 | Troponin T type 1 | 3.92 | 1.3E-03 |
NM_178012.3 | TUBB2B | Tubulin, beta 2B | 3.92 | 3.4E-03 |
NM_001928.2 | CFD | Complement factor D (adipsin) | 3.87 | 5.4E-03 |
NM_006117.2 | PECI | Peroxisomal D3, D2-enoyl-CoA isomerase | 3.83 | 6.8E-03 |
NM_005319.3 | HIST1H1C | Histone 1, H1c | 3.78 | 1.3E-03 |
NM_005952.2 | MT1X | Metallothionein 1× | 3.66 | 5.9E-03 |
NM_017707.2 | DDEFL1 | Development and differentiation enhancing factor-like 1 | 3.60 | 6.6E-04 |
Repressed | Â | Â | Â | Â |
NM_206963.1 | RARRES1 | Retinoic acid receptor responder 1 | -2.41 | 1.0E-02 |
NM_001031733.1 | CALML4 | Calmodulin-like 4 | -2.42 | 1.1E-03 |
NM_007167.2 | ZMYM6 | Zinc finger, MYM-type 6 | -2.43 | 8.8E-03 |
NM_002423.3 | MMP7 | Matrix metallopeptidase 7 | -2.55 | 7.1E-03 |
NM_080911.1 | UNG | Uracil-DNA glycosylase | -2.58 | 1.1E-02 |
NM_145810.1 | CDCA7 | Cell division cycle associated 7 | -2.59 | 2.0E-03 |
NM_006169.2 | NNMT | Nicotinamide N-methyltransferase | -2.61 | 4.4E-03 |
NM_020371.2 | AVEN | Apoptosis, caspase activation inhibitor | -2.66 | 4.3E-04 |
NM_005375.2 | MYB | V-myb myeloblastosis viral oncogene homolog | -2.72 | 1.2E-03 |
NM_052813.2 | CARD9 | Caspase recruitment domain family, member 9 | -2.75 | 1.8E-02 |
NM_014312.3 | VSIG2 | V-set and immunoglobulin domain containing 2 | -2.81 | 2.5E-03 |
NM_020384.2 | CLDN2 | Claudin 2 | -3.03 | 2.5E-02 |
NM_020299.3 | AKR1B10 | Aldo-keto reductase family 1, member B10 | -3.20 | 1.7E-02 |
NM_007193.3 | ANXA10 | Annexin A10 | -3.69 | 4.1E-03 |
NM_001071.1 | TYMS | Thymidylate synthase | -3.82 | 1.1E-03 |
Induced | Â | Â | Vorinostat | |
NM_002305.2 | LGALS1 | Lectin, galactoside-binding, soluble, 1 | 5.07 | 1.6E-03 |
NM_003088.2 | FSCN1 | Fascin homolog 1, actin-bundling protein | 4.61 | 2.3E-04 |
NM_004223.3 | UBE2L6 | Ubiquitin-conjugating enzyme E2L 6 | 4.47 | 1.2E-02 |
NM_006262.3 | PRPH | Peripherin | 4.39 | 5.9E-03 |
NM_182908.3 | DHRS2 | Dehydrogenase/reductase member 2 | 4.21 | 1.1E-04 |
NM_006086.2 | TUBB3 | Tubulin, beta 3 | 4.08 | 1.6E-03 |
NM_002084.2 | GPX3 | Glutathione peroxidase 3 | 3.98 | 2.0E-03 |
NM_017707.2 | DDEFL1 | Development and differentiation enhancing factor-like 1 | 3.74 | 7.9E-03 |
NM_001928.2 | CFD | Complement factor D | 3.72 | 1.5E-02 |
NM_003078.3 | SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | 3.67 | 2.0E-02 |
NM_003283.3 | TNNT1 | Troponin T type 1 | 3.67 | 1.5E-03 |
NM_006117.2 | PECI | Peroxisomal D3, D2-enoyl-CoA isomerase | 3.62 | 3.5E-03 |
NM_178012.3 | TUBB2B | Tubulin, beta 2B | 3.59 | 7.1E-04 |
NM_015896.2 | ZMYND10 | Zinc finger, MYND-type containing 10 | 3.57 | 8.8E-03 |
NM_005319.3 | HIST1H1C | Histone 1, H1c | 3.50 | 7.7E-03 |
Repressed | Â | Â | Â | Â |
NM_001031733.1 | CALML4 | Calmodulin-like 4 | -2.43 | 5.0E-03 |
NM_005752.2 | CLEC3A | C-type lectin domain family 3, member A | -2.45 | 7.5E-04 |
NM_005375.2 | MYB | V-myb myeloblastosis viral oncogene homolog | -2.56 | 3.5E-03 |
NM_020371.2 | AVEN | Apoptosis, caspase activation inhibitor | -2.60 | 7.8E-03 |
NM_014312.3 | VSIG2 | V-set and immunoglobulin domain containing 2 | -2.62 | 3.5E-04 |
NM_005117.2 | FGF19 | Fibroblast growth factor 19 | -2.64 | 9.3E-03 |
NM_007167.2 | ZMYM6 | Zinc finger, MYM-type 6 | -2.67 | 1.6E-02 |
NM_004688.1 | NMI | N-myc (and STAT) interactor | -2.69 | 3.9E-04 |
NM_052813.2 | CARD9 | Caspase recruitment domain family, member 9 | -2.70 | 2.8E-04 |
NM_080911.1 | UNG | Uracil-DNA glycosylase | -2.79 | 1.6E-02 |
NM_018689.1 | KIAA1199 | KIAA1199 | -2.95 | 3.2E-04 |
NM_020384.2 | CLDN2 | Claudin 2 | -3.06 | 2.3E-02 |
NM_020299.3 | AKR1B10 | Aldo-keto reductase family 1, member B10 | -3.07 | 2.8E-05 |
NM_007193.3 | ANXA10 | Annexin A10 | -3.49 | 1.3E-02 |
NM_001071.1 | TYMS | Thymidylate synthase | -3.59 | 8.3E-03 |
NM_001031733.1 | CALML4 | Calmodulin-like 4 | -2.43 | 5.0E-03 |