Table 4 Selected Human Genes and Disease Phenotype (MeSH counts), positive associations
Gene ID | HUGO Gene Sym. | MESH TERM 1 | MESH TERM 2 | MESH TERM 3 | MESH TERM 4 |
|---|---|---|---|---|---|
348 | APOE | Alzheimer Disease(70) | Coronary Disease(8) | Cardiovascular Diseases(7) | Diabetes Mellitus, Type 2(6) |
1636 | ACE | Hypertension(47) | Diabetes Mellitus, Type 2(25) | Myocardial Infarction(17) | Coronary Disease(16) |
3119 | HLA-DQB1 | Diabetes Mellitus, Type 1(30) | Papillomavirus Infections(7) | Celiac Disease(6) | Tuberculosis, Pulmonary(5) |
1493 | CTLA4 | Diabetes Mellitus, Type 1(28) | Graves Disease(21) | Thyroiditis, Autoimmune(10) | Autoimmune Diseases(8) |
183 | AGT | Hypertension(24) | Coronary Disease(6) | Diabetic Nephropathies(5) | Myocardial Infarction(5) |
1814 | DRD3 | Schizophrenia(24) | Dyskinesia, Drug-Induced(6) | Psychotic Disorders(5) | Alcoholism(2) |
4846 | NOS3 | Hypertension(20) | Myocardial Infarction(18) | Coronary Artery Disease(15) | Coronary Disease(12) |
3075 | CFH | Macular Degeneration(19) | Choroidal Neovascularization(3) | Hemolytic-Uremic Syndrome(2) | Atrophy(2) |
3077 | HFE | Hemochromatosis(18) | Cardiovascular Diseases(1) | Colorectal Neoplasms(1) | Liver Cirrhosis(1) |
3356 | HTR2A | Schizophrenia(18) | Alzheimer Disease(4) | Depressive Disorder(4) | Depressive Disorder, Major(4) |
1585 | CYP11B2 | Hypertension(18) | Cardiovascular Diseases(2) | Ventricular Dysfunction, Left(2) | Cardiomyopathy, Dilated(2) |
5468 | PPARG | Diabetes Mellitus, Type 2(18) | Obesity(11) | Diabetes Mellitus(6) | Insulin Resistance(4) |
2784 | GNB3 | Hypertension(18) | Insulin Resistance(4) | Diabetes Mellitus, Type 2(3) | Obesity(3) |
1815 | DRD4 | Attention Def. Dis. with Hyperact. (17) | Schizophrenia(8) | Substance-Related Disorders(4) | Mood Disorders(4) |
1813 | DRD2 | Alcoholism(17) | Schizophrenia(14) | Personality Disorders(2) | Depressive Disorder(2) |
155 | ADRB3 | Obesity(17) | Diabetes Mellitus, Type 2(9) | Insulin Resistance(6) | Endometrial Neoplasms(2) |
9370 | ADIPOQ | Diabetes Mellitus, Type 2(17) | Insulin Resistance(11) | Obesity(8) | Hypertension(4) |
3123 | HLA-DRB1 | Arthritis, Rheumatoid(16) | Diabetes Mellitus, Type 1(16) | Multiple Sclerosis(8) | Lupus Erythematosus, Systemic(7) |
118 | ADD1 | Hypertension(16) | Cardiovascular Diseases(3) | Cerebral Hemorrhage(1) | Diabetic Angiopathies(1) |
3117 | HLA-DQA1 | Diabetes Mellitus, Type 1(15) | Graves Disease(4) | Autoimmune Diseases(4) | Celiac Disease(4) |
1956 | EGFR | Lung Neoplasms(15) | Carcinoma, Non-SC Lung(10) | Adenocarcinoma(6) | Neoplasm Recurrence, Local(3) |
6690 | SPINK1 | Pancreatitis(15) | Chronic Disease(11) | Acute Disease(3) | Pancreatitis, Alcoholic(3) |
6934 | TCF7L2 | Diabetes Mellitus, Type 2(15) | Insulin Resistance(4) | Diabetes Mellitus(2) | Liver Neoplasms(1) |
1234 | CCR5 | HIV Infections(14) | Diabetes Mellitus, Type 2(4) | Diabetic Nephropathies(4) | Asthma(3) |
5663 | PSEN1 | Alzheimer Disease(14) | Down Syndrome(2) | Dementia(1) | Cerebral Amyloid Angiopathy(1) |
11132 | CAPN10 | Diabetes Mellitus, Type 2(14) | Insulin Resistance(3) | Polycystic Ovary Syndrome(2) | Obesity(2) |
3553 | IL1B | Stomach Neoplasms(14) | Helicobacter Infections(6) | Alzheimer Disease(5) | Periodontitis(3) |
6532 | SLC6A4 | Depressive Disorder, Major(13) | Depressive Disorder(13) | Bipolar Disorder(10) | Alcoholism(8) |
4210 | MEFV | Familial Mediterranean Fever(13) | Amyloidosis(4) | Behcet Syndrome(3) | Colitis, Ulcerative(2) |
3172 | HNF4A | Diabetes Mellitus, Type 2(13) | Glucose Intolerance(2) | Birth Weight(1) | Fetal Macrosomia(1) |
7157 | TP53 | Carcinoma, Squamous Cell(13) | Lung Neoplasms(12) | Breast Neoplasms(10) | Carcinoma, Non-SC Lung(9) |
672 | BRCA1 | Breast Neoplasms(12) | Ovarian Neoplasms(5) | Carcinoma, Endometrioid(1) | DNA Damage(1) |
185 | AGTR1 | Hypertension(12) | Myocardial Infarction(3) | Coronary Disease(3) | Pregnancy Comp., Cardiovascular(2) |
154 | ADRB2 | Asthma(12) | Obesity(10) | Hypertension(8) | Diabetes Mellitus, Type 2(4) |
3953 | LEPR | Obesity(12) | Body Weight(4) | Insulin Resistance(4) | Glucose Intolerance(3) |
2169 | FABP2 | Diabetes Mellitus, Type 2(12) | Insulin Resistance(10) | Obesity(7) | Hyperlipidemias(4) |
929 | CD14 | Asthma(12) | Myocardial Infarction(5) | Arteriosclerosis(4) | Colitis, Ulcerative(4) |
26191 | PTPN22 | Arthritis, Rheumatoid(11) | Diabetes Mellitus, Type 1(9) | Lupus Erythematosus, Systemic(5) | Arthritis, Psoriatic(2) |
3596 | IL13 | Asthma(11) | Hypersensitivity, Immediate(4) | Pulmonary Dis., Chronic Obstr. (4) | Respiratory Hypersensitivity(2) |
1080 | CFTR | Cystic Fibrosis(10) | Pancreatitis(5) | Chronic Disease(3) | Acute Disease(2) |