Figure 5

Gene expression profile of trisomic BG01V APCs is similar to glioblastomas. A. Heat map of unsupervised hierarchical cluster analysis of microarray hybridization data derived from the twenty-three glioblastoma patient samples (N), the three trisomic BG01V APC samples (G) and the three diploid H9 APC samples (C). Relative over expression is indicated by red and under expression by blue in the heat map. Data filtered using a p value of < 0.001. Individual gene dot plots displaying changes in mean expression levels of four transcripts: GPNMB (panel B), HDAC9 (panel C), MGMT (panel D) and TNFRSF11b (panel E). Each panel shows the individual hybridization data for all samples from each of the three groups, including the twenty-three glioblastoma samples (green), the three biological replicates of trisomic BG01V APCs (blue) and the three independent replicates of diploid H9 APCs (red).