From: Predicting environmental chemical factors associated with disease-related gene expression data
Actual Chemical Exposure (GEO accession) | Chemicals Predicted | Hypergeometric P-value | Rank (Percentile) | q-value | Relevant Genes Expressed |
---|---|---|---|---|---|
Vitamin D3 on H. sapiens muscle cells (GSE5145) | Calcitriol | 1 × 10-23 | 1 (100) | 0 | VDR (25), CYP24A1 (14) |
TCDD on M. musculus (GSE10082) | TCDD | 2 × 10-15 | 3 (99) | 0 | CYP1A1 (59), CYP1B1 (15), AHRR(6), CYP1A2 (14) |
Bisphenol A on H. sapiens Ishikawa cells (GSE17624) | Bisphenol A | 1 × 10-6 | 15 (99) | 0 | ESR1(31), ESR2(7), S100G (6) |
Zinc sulfate on H. sapiens bronchial tissue (GSE2111) | Zinc sulfate | 3 × 10-3 | 15 (99) | 0.04 | SLC30A1 (3), MT1F(2), MT1G(2) |
Estradiol on M. musculus thymus (GSE2889) | Estradiol | 5 × 10-3 | 17 (99) | 0.08 | C3(6), LPL (4), CTSB (2) |
Estradiol on H. sapiens MCF7 cell line (GSE11352) | Estradiol | 5 × 10-3 | 19 (99) | 0.08 | ISG20 (2), MGP (2), SERPINA1 (2) |