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Table 3 Prediction of environmental chemicals associated with lung cancer samples (GSE10072).

From: Predicting environmental chemical factors associated with disease-related gene expression data

Chemical Predicted Hypergeometric P-value Rank (percentile) q-value Relevant genes in set (number of references) Citations
Doxorubicin 1 × 10-6 16 (99) 4 × 10-4 CASP3(60), ABCB1(28), BAX(26), BCL2 (23) [54]
Sodium arsenite 8 × 10-6 20 (98) 4 × 10-4 JUN(13), NQ01(6), EGR1(6) [5557]
Vanadium pentoxide 1 × 10-5 24 (98) 6 × 10-4 HBEGF(3), CDK7(1), CDKN1B (1), CDKN1C(1) [58]
Dimethylnitrosamine 6 × 10-5 27 (98) 7 × 10-4 TGFB1(23), TIMP1(15), PCNA(6) [31]
Indomethacin 2 × 10-4 34 (97) 0.002 BIRC5(3), CDKN1B(2), MMP9(2) [5961]
2-Acetylaminofluorene 3 × 10-4 36 (97) 0.003 ABCB1(4), ABCG2(4), KRT19(2) [62]
Asbestos, Serpentine 4 × 10-4 39 (97) 0.004 IL6(2), MMP9(2), MMP12(2), PDGFB(2) [63]
  1. Shown in the table are a subset of the highly ranked chemicals (p < 0.001) that were predicted to have association with lung cancer gene expression (non-smokers) and had evidence of association with the MeSH term "Lung Neoplasms". Columns have similar definitions as Table 2.