Figure 3
![Figure 3](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2F1755-8794-3-19/MediaObjects/12920_2009_Article_154_Fig3_HTML.jpg)
Counting for the cross-talk ranking values (CTRVs). CTRV is a ranking value which reflects the potential of a protein in connection with multiple pathways. (A) All proteins connected with protein A belong to the same pathway A. In this case, the CTRV of protein A will not be changed. (B) If protein A connects with protein B, which belongs to a different pathway, then both CTRVs of protein A and B will be added by one.