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Table 3 Cross-talk ranking values (CTRVs) and link values of significant proteins in PPAN.

From: Dynamic cross-talk analysis among TNF-R, TLR-4 and IL-1R signalings in TNFα-induced inflammatory responses

No. Protein CTRV Link No. Protein CTRV Link
1 IRAK1 108 140 31 IL1R1 21 21
2 TRAF6 83 124 32 FADD 19 55
3 NIK 77 89 33 GRB2 18 46
4 A20 61 61 34 TAK1 17 66
5 MYD88 59 107 35 SOCS1 17 17
6 TRAF2 58 198 36 TRIF 16 54
7 IKKα 55 83 37 TMED1 12 12
8 SIGIRR 53 73 38 CASP8 10 87
9 TLR4 53 53 39 TAB2 10 53
10 IKKγ 52 84 40 CAV1 10 44
11 IKKβ 47 97 41 TAB1 9 44
12 BCL10 43 62 42 TTRAP 8 8
13 UBE2N 41 41 43 ECSIT 8 50
14 IRAK4 38 112 44 CYLD 6 6
15 RIP 38 57 45 TNF 0 48
16 TRAF3 37 57 46 TNFR2 0 39
17 IRAK3 36 36 47 IKKε 0 29
18 ST2L 32 32 48 PELI2 0 19
19 TNIP3 32 32 49 IL1B 0 18
20 PTPN11 31 31 50 MEKK3 0 18
21 TIRAP 29 40 51 TRAM 0 18
22 TRAF4 27 27 52 IL1A 0 17
23 TOLLIP 26 47 53 IL1R2 0 17
24 RNF216 25 25 54 TRAF5 0 17
25 TNFR1 24 111 55 SOS1 0 10
26 RIP3 23 93 56 IRF3 0 9
27 TRADD 23 32 57 NOD2 0 0
28 TBK1 22 39 58 CD14 0 0
29 PELI1 21 49 59 SARM1 0 0
30 TANK 21 40 60 FLN29 0 0
  1. To integrate the information from the complex PPANs, the cross-talk ranking values (CTRVs) at different time stages are summed up for each protein. In contrast with CTRVs, the values of link represent the total number of protein-protein associations at six time stages of each protein. It reveals that not all nodes with high connective degree will also have high CTRVs such as CASP8.