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Table 2 Genes over-expressed in the megakaryoblastic leukaemias

From: Gene profiling of the erythro- and megakaryoblastic leukaemias induced by the Graffi murine retrovirus

Probeset Gene SAM results Leukaemic samples * GSE 6593
   d-score p-value FDR T1 T2 T3 B1 B2 B3 M E1 E2 E3 Mk1 Mk2 Mk3  
Genes potentially implicated in the disease **
Mk                   
1443260_at Meis1 12.0 <0.001 0.1 -1.5 -1.3 -1.7 -1.5 -1.3 -1.7 -1.4 -1.4 -1.3 -1.3 4.5 5.9 4.0 ND
1428647_at Pbx1 10.2 <0.001 0.07 -1.6 -1.1 -1.1 -1.3 -1.3 -1.6 -1.2 -1.2 -1.1 -1.4 4.3 5.3 3.3 ND
1417155_at Nmyc 16.0 <0.001 0.08 -2.0 -1.6 -1.9 -0.7 -0.6 -1.2 -1.6 -1.8 -1.5 -1.9 4.8 5.6 4.4 NS
1451332_at Evi3 13.0 <0.001 0.08 -1.1 -1.3 -1.1 -1.1 -1.0 -0.9 -0.7 -0.7 -0.6 -0.9 3.5 3.3 2.6 NS
1441350_at Fgf3 5.4 0.002 0.12 -0.7 -0.7 -0.6 -0.6 -0.7 -0.8 -0.6 -0.4 -0.6 -0.5 1.3 2.9 1.9
1417552_at Fap 7.2 <0.001 0.09 -1.7 -1.6 -1.7 -1.8 -1.7 -1.7 -1.7 -1.5 -1.6 -1.4 5.9 7.0 3.6 ND
1438325_at Evi1 4.5 0.005 0.16 -1.8 -0.9 -1.4 -1.7 -1.7 -1.4 -1.8 -1.1 -1.4 -1.5 7.3 2.4 4.8 ND
1440964_s_at Cbfa2t3h 11.0 <0.001 0.08 -0.4 -0.7 -1.1 -0.3 -0.6 -0.3 -0.1 0.2 -0.6 -0.2 1.4 1.4 1.2 NS
MkE1                   
1452072_at Myct1 7.2 <0.001 0.07 -2.0 -1.7 -1.7 -1.6 -1.5 -1.6 -1.4 2.0 -1.1 0.6 3.0 4.5 2.5 NS
MkMB                   
1437247_at FosL2 10.3 <0.001 0.01 -0.8 -0.5 -0.8 -0.7 -0.7 -0.8 1.8 -0.5 -0.5 -0.6 1.6 1.6 0.8 ND
1417409_at Jun 5.1 <0.001 0.03 -0.3 -1.4 -3.3 1 1.1 1.4 4.1 -1.3 -1.5 -2.3 0.8 0.8 0.91
1434705_at Ctbp2 15.3 <0.001 0.01 -1.1 -1.0 -1.6 -0.9 -1.1 -1.3 3.2 -1.2 -1.4 -1.9 3.3 2.7 2.4 NS
1452514_a_at Kit 10.5 <0.001 0.01 -2.2 -2.1 -2.2 -2.2 -2.3 1.2 2.8 -1.7 -1.6 -2.2 3.8 4.6 4.0
1418747_at Sfpi1 9.9 <0.001 <0.01 -2.6 -1.7 -1.7 1.4 0.9 1.1 3.0 -1.7 -1.4 -1.8 1.2 2.1 1.1
1452410_a_at Fes 10.2 <0.001 <0.01 -2.3 -1.7 -1.7 1.8 0.5 1.0 3.0 -1.4 -2.0 -1.9 1.4 2.2 1.1
1428669_at Bmyc 5.8 <0.001 0.04 0.8 -0.9 0.9 -1.5 -1.2 -0.5 1.3 -1.6 -1.2 -1.4 1.7 2.2 1.4
1420710_at Rel 5.8 <0.001 0.02 -0.4 0.0 -0.8 0.4 1.0 0.9 1.0 -0.9 -1.3 -1.1 0.6 -0.1 0.6 NS
Genes potentially implicated in inflammation response
MkMB                   
1449222_at Ebi3 11.2 <0.001 0.01 -1.4 -1.3 -1.2 -1.4 -1.2 -1.3 3.6 -0.7 -1.1 -1.6 2.2 3.1 2.23
1418262_at Syk 1.6 <0.001 <0.01 -2.4 -2.5 -2.8 2.8 2.4 2.6 1.5 -1.6 -2.2 -2.8 1.4 1.6 1.96 NS
1419132_at Tlr2 6.7 <0.001 0.01 -0.8 -1.4 -1.6 0.6 0.1 0.6 2.4 -0.9 -1.4 -1.5 1 2 0.9
1418163_at Tlr4 6.3 <0.001 0.01 -1.8 -1.6 -1.4 0.5 1.8 2.2 2.5 -1.2 -0.8 -1.3 0.4 0.7 0.0 ND
1456046_at C1qr1 8.1 <0.001 <0.01 -2.2 -3.7 -4.2 4.1 3.9 4.1 3.7 -2.3 -2.2 -4.1 0.9 0.6 1.4 ND
Genes selected for RT-PCR validation
1434141_at Gucy1a3 18.2 <0.001 0.07 -1.2 -0.6 -1.0 -1.0 -1.1 -1.2 -1.0 0.2 -1.1 -1.0 3.0 3.2 2.7 -
1437687_x_at Fkbp9 23.7 <0.001 0.07 -1.4 -1.3 -1.6 -1.3 -1.3 -1.3 -1.1 -1.0 -1.0 -1.1 4.1 4.6 3.9 NS
1453771_at Gulp1 14.2 <0.001 0.07 -0.7 -0.7 -0.5 -0.6 -0.9 -0.9 -0.9 -1.0 -0.9 -0.9 3.1 2.6 2.3 -
1448561_at Ncf2 18.5 <0.001 <0.01 -2.6 -2.4 -2.1 2.0 1.6 1.6 3.0 -2.1 -2.2 -2.4 1.6 2.5 1.6 NS
1450333_a_at Gata2 7.4 <0.001 0.01 -2.3 -2.0 -2.3 -2.1 -2.4 -1.9 -1.6 0.2 2.4 1.1 3.6 4.0 3.4
  1. * amplitude of deviation from the mean calculated from the RMA values
  2. ** cell cycle/cell growth/development/angiogenesis/DNA repair/transcription regulation
  3. ND (not determined), NS (not significant)