Table 2 Genes over-expressed in the megakaryoblastic leukaemias
Probeset | Gene | SAM results | Leukaemic samples * | GSE 6593 | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | d-score | p-value | FDR | T1 | T2 | T3 | B1 | B2 | B3 | M | E1 | E2 | E3 | Mk1 | Mk2 | Mk3 | Â |
Genes potentially implicated in the disease ** | ||||||||||||||||||
Mk | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1443260_at | Meis1 | 12.0 | <0.001 | 0.1 | -1.5 | -1.3 | -1.7 | -1.5 | -1.3 | -1.7 | -1.4 | -1.4 | -1.3 | -1.3 | 4.5 | 5.9 | 4.0 | ND |
1428647_at | Pbx1 | 10.2 | <0.001 | 0.07 | -1.6 | -1.1 | -1.1 | -1.3 | -1.3 | -1.6 | -1.2 | -1.2 | -1.1 | -1.4 | 4.3 | 5.3 | 3.3 | ND |
1417155_at | Nmyc | 16.0 | <0.001 | 0.08 | -2.0 | -1.6 | -1.9 | -0.7 | -0.6 | -1.2 | -1.6 | -1.8 | -1.5 | -1.9 | 4.8 | 5.6 | 4.4 | NS |
1451332_at | Evi3 | 13.0 | <0.001 | 0.08 | -1.1 | -1.3 | -1.1 | -1.1 | -1.0 | -0.9 | -0.7 | -0.7 | -0.6 | -0.9 | 3.5 | 3.3 | 2.6 | NS |
1441350_at | Fgf3 | 5.4 | 0.002 | 0.12 | -0.7 | -0.7 | -0.6 | -0.6 | -0.7 | -0.8 | -0.6 | -0.4 | -0.6 | -0.5 | 1.3 | 2.9 | 1.9 | ↓ |
1417552_at | Fap | 7.2 | <0.001 | 0.09 | -1.7 | -1.6 | -1.7 | -1.8 | -1.7 | -1.7 | -1.7 | -1.5 | -1.6 | -1.4 | 5.9 | 7.0 | 3.6 | ND |
1438325_at | Evi1 | 4.5 | 0.005 | 0.16 | -1.8 | -0.9 | -1.4 | -1.7 | -1.7 | -1.4 | -1.8 | -1.1 | -1.4 | -1.5 | 7.3 | 2.4 | 4.8 | ND |
1440964_s_at | Cbfa2t3h | 11.0 | <0.001 | 0.08 | -0.4 | -0.7 | -1.1 | -0.3 | -0.6 | -0.3 | -0.1 | 0.2 | -0.6 | -0.2 | 1.4 | 1.4 | 1.2 | NS |
MkE1 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1452072_at | Myct1 | 7.2 | <0.001 | 0.07 | -2.0 | -1.7 | -1.7 | -1.6 | -1.5 | -1.6 | -1.4 | 2.0 | -1.1 | 0.6 | 3.0 | 4.5 | 2.5 | NS |
MkMB | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1437247_at | FosL2 | 10.3 | <0.001 | 0.01 | -0.8 | -0.5 | -0.8 | -0.7 | -0.7 | -0.8 | 1.8 | -0.5 | -0.5 | -0.6 | 1.6 | 1.6 | 0.8 | ND |
1417409_at | Jun | 5.1 | <0.001 | 0.03 | -0.3 | -1.4 | -3.3 | 1 | 1.1 | 1.4 | 4.1 | -1.3 | -1.5 | -2.3 | 0.8 | 0.8 | 0.91 | ↓ |
1434705_at | Ctbp2 | 15.3 | <0.001 | 0.01 | -1.1 | -1.0 | -1.6 | -0.9 | -1.1 | -1.3 | 3.2 | -1.2 | -1.4 | -1.9 | 3.3 | 2.7 | 2.4 | NS |
1452514_a_at | Kit | 10.5 | <0.001 | 0.01 | -2.2 | -2.1 | -2.2 | -2.2 | -2.3 | 1.2 | 2.8 | -1.7 | -1.6 | -2.2 | 3.8 | 4.6 | 4.0 | ↓ |
1418747_at | Sfpi1 | 9.9 | <0.001 | <0.01 | -2.6 | -1.7 | -1.7 | 1.4 | 0.9 | 1.1 | 3.0 | -1.7 | -1.4 | -1.8 | 1.2 | 2.1 | 1.1 | ↓ |
1452410_a_at | Fes | 10.2 | <0.001 | <0.01 | -2.3 | -1.7 | -1.7 | 1.8 | 0.5 | 1.0 | 3.0 | -1.4 | -2.0 | -1.9 | 1.4 | 2.2 | 1.1 | ↓ |
1428669_at | Bmyc | 5.8 | <0.001 | 0.04 | 0.8 | -0.9 | 0.9 | -1.5 | -1.2 | -0.5 | 1.3 | -1.6 | -1.2 | -1.4 | 1.7 | 2.2 | 1.4 | ↓ |
1420710_at | Rel | 5.8 | <0.001 | 0.02 | -0.4 | 0.0 | -0.8 | 0.4 | 1.0 | 0.9 | 1.0 | -0.9 | -1.3 | -1.1 | 0.6 | -0.1 | 0.6 | NS |
Genes potentially implicated in inflammation response | ||||||||||||||||||
MkMB | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1449222_at | Ebi3 | 11.2 | <0.001 | 0.01 | -1.4 | -1.3 | -1.2 | -1.4 | -1.2 | -1.3 | 3.6 | -0.7 | -1.1 | -1.6 | 2.2 | 3.1 | 2.23 | ↓ |
1418262_at | Syk | 1.6 | <0.001 | <0.01 | -2.4 | -2.5 | -2.8 | 2.8 | 2.4 | 2.6 | 1.5 | -1.6 | -2.2 | -2.8 | 1.4 | 1.6 | 1.96 | NS |
1419132_at | Tlr2 | 6.7 | <0.001 | 0.01 | -0.8 | -1.4 | -1.6 | 0.6 | 0.1 | 0.6 | 2.4 | -0.9 | -1.4 | -1.5 | 1 | 2 | 0.9 | ↓ |
1418163_at | Tlr4 | 6.3 | <0.001 | 0.01 | -1.8 | -1.6 | -1.4 | 0.5 | 1.8 | 2.2 | 2.5 | -1.2 | -0.8 | -1.3 | 0.4 | 0.7 | 0.0 | ND |
1456046_at | C1qr1 | 8.1 | <0.001 | <0.01 | -2.2 | -3.7 | -4.2 | 4.1 | 3.9 | 4.1 | 3.7 | -2.3 | -2.2 | -4.1 | 0.9 | 0.6 | 1.4 | ND |
Genes selected for RT-PCR validation | ||||||||||||||||||
1434141_at | Gucy1a3 | 18.2 | <0.001 | 0.07 | -1.2 | -0.6 | -1.0 | -1.0 | -1.1 | -1.2 | -1.0 | 0.2 | -1.1 | -1.0 | 3.0 | 3.2 | 2.7 | - |
1437687_x_at | Fkbp9 | 23.7 | <0.001 | 0.07 | -1.4 | -1.3 | -1.6 | -1.3 | -1.3 | -1.3 | -1.1 | -1.0 | -1.0 | -1.1 | 4.1 | 4.6 | 3.9 | NS |
1453771_at | Gulp1 | 14.2 | <0.001 | 0.07 | -0.7 | -0.7 | -0.5 | -0.6 | -0.9 | -0.9 | -0.9 | -1.0 | -0.9 | -0.9 | 3.1 | 2.6 | 2.3 | - |
1448561_at | Ncf2 | 18.5 | <0.001 | <0.01 | -2.6 | -2.4 | -2.1 | 2.0 | 1.6 | 1.6 | 3.0 | -2.1 | -2.2 | -2.4 | 1.6 | 2.5 | 1.6 | NS |
1450333_a_at | Gata2 | 7.4 | <0.001 | 0.01 | -2.3 | -2.0 | -2.3 | -2.1 | -2.4 | -1.9 | -1.6 | 0.2 | 2.4 | 1.1 | 3.6 | 4.0 | 3.4 | ↓ |