Figure 4

Expression of Lipolytic genes in LAT vs HAT. Gene expression of lipolytic genes (A) LPL and LIPC, (B) PNLIP and EL and (E) CES1, MGLL, HSL, perilipin and (F) adiponutrin in SC adipose tissue from LAT (hatched bars) and HAT (solid bars) as assessed by microarray where LAT expression is set at 100%. Correlation between the ASP triad of genes and (C) LPL and (D) LIPC are shown for C3 (open circles), FB (solid circles), and adipsin (stars). R values (Spearman coefficients) for C3, FB, and adipsin respectively are (C) 0.430, 0.600, 0.564 and (D) 0.673, 0.842, 0.709. Correlations between lipid metabolism genes GLUT4 and DGAT2 with (G) HSL and (H) perilipin are shown for GLUT4 (solid circles) and DGAT2 (stars). R values (Spearman coefficients) for GLUT4 and DGAT2 respectively are (G) -0.952, 0.915 and (H) -0.564, 0.515. Lines are based on linear regression. Data is expressed as means ± SEM where * p < 0.025, ** p < 0.01 and *** p < 0.001.