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Figure 3 | BMC Medical Genomics

Figure 3

From: Molecular signature of response and potential pathways related to resistance to the HSP90 inhibitor, 17AAG, in breast cancer

Figure 3

Effect of HSP90 inhibition by 17AAG in a biopsy from a breast cancer patient. A) Cell cycle analysis in untreated cells and cells treated with 17AAG for 24 H and 48 H, exhibiting G2/M arrest at both time points. B) Validation of a group of genes from the signature of response to 17AAG in the primary tumor cells. All these genes showed increased expression after treatment >2fold at 24 H or 48 H, as occurred in the sensitive cell lines.

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