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Table 1 Differentially expressed host genes which mapped to immune related responses.

From: Chemokine gene expression in lung CD8 T cells correlates with protective immunity in mice immunized intra-nasally with Adenovirus-85A

Annotation Name Accession Fold Difference
I Cytokine and chemokine-mediated immunity and signalling    lung i.n. vs spleen i.d. lung i.n.vs lung i.d.
CD40 antigen Cd40 NM_170702.2   3.0
Chemokine (C motif) ligand 1 Xcl1 NM_008510.1 4.0 8.0
Chemokine (C-C motif) ligand 1 Ccl1 NM_011329.1 9.7 6.7
Chemokine (C-C motif) ligand 2 Ccl2 NM_011333.1 3.2 2.2
Chemokine (C-C motif) ligand 3 Ccl3 NM_011337.1   4.3
Chemokine (C-C motif) ligand 4 Ccl4 NM_013652.1   7.4
Chemokine (C-C motif) ligand 5 Ccl5 NM_013653.1   3.4
Chemokine (C-C motif) ligand 7 Ccl7 NM_013654 17.9 6.9
Chemokine (C-C motif) ligand 8 Ccl8 NM_021443.1 10.7 4.3
Chemokine (C-C motif) ligand 12 Ccl12 NM_011331 2.7  
Chemokine (C-C motif) ligand 24 Ccl24 NM_019577.2 -4.3  
Chemokine (C-X-C motif) ligand 1 Cxcl1 NM_008176.1 2.9  
Chemokine (C-X-C motif) ligand 2 Cxcl2 NM_009140 2.4  
Chemokine (C-X-C motif) ligand 9 Cxcl9 NM_008599   12.6
Chemokine (C-C motif) receptor 3 Ccr3 NM_009914.2 -2.1  
Chemokine (C-X-C motif) receptor 6 Cxcr6 NM_030712.1   5.3
Colony stimulating factor 1 (macrophage) Csf1 NM_007778.1 2.1  
Colony stimulating factor 3 receptor (granulocyte) Csf3r NM_007782.1 -2.1  
Cytokine inducible SH2-containing protein Cish NM_009895.2 4.7 4.5
Interferon gamma Ifng NM_008337.1   5.2
Interferon gamma receptor 2 Ifngr2 NM_008338.2 3.2  
Interleukin 18 Il18 NM_008360.1 -4.3  
Lymphocyte-activation gene 3 Lag3 NM_008479.1 2.8 5.0
Protein tyrosine phosphatase, non-receptor type 6 Hcph NM_013545.1   2.0
Signal-regulatory protein alpha Ptp4a3 NM_008975.2 -2.1  
Transferrin Trf NM_133977.1 -8.8  
Tumor necrosis factor Tnf NM_013693   2.6
II Inflammation mediated pathway     
Cyclin-dependent kinase inhibitor 1A (P21) Cdkn1a NM_007669.2 2.2  
Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog Fgr NM_010208 -3.5  
Integrin alpha 9 Itga9 NM_133721.1 -3.0  
Procollagen, type XIV, alpha 1 Col14a1 AK052963 -3.4  
Prostaglandin-endoperoxide synthase 1 Ptgs1 NM_008969.1 -7.0  
Vav2 oncogene Vav2 NM_009500.1 -3.7  
III Interferon-stimulated genes     
2'-5' oligoadenylate synthetase-like 2 Oasl2 NM_011854.1 4.0 3.3
2'-5' oligoadenylate synthetase 1G Oas1g NM_011852.2   3.2
Guanylate nucleotide binding protein 1 Gbp1 NM_010259.1 2.2 5.5
Guanylate nucleotide binding protein 2 Gbp2 NM_010260.1   4.4
Guanylate nucleotide binding protein 4 Gbp4 NM_018734.2   3.2
Interferon activated gene 202B Ifi202b NM_008327.1   2.4
Interferon-induced protein with tetratricopeptide repeats 2 Ifit2 NM_008332.2   2.0
Interferon-induced protein with tetratricopeptide repeats 3 Ifit3 NM_010501.1   3.9
Interferon regulatory factor 8 Icsbp1 NM_008320.2   3.2
Signal transducer and activator of transcription 1 Stat1 NM_009283   3.0
SLAM family member 8 Slamf8 XM_129596.2   5.0
IV T cell activation     
Beta-2 microglobulin B2m NM_009735.2   2.3
Cathepsin S Ctss NM_021281.1   3.0
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) li BC003476   5.6
CD86 antigen Cd86 NM_019388.2 -2.3 2.5
CD274 antigen Pdcd1lg1 NM_021893.2 2.5 3.8
Cytotoxic T-lymphocyte-associated protein 4 Ctla4 NM_009843.2   3.9
Histocompatibility 2, Q region locus 6 H2-Q6 NM_207648   3.0
Interferon gamma inducible protein 30 Ifi30 NM_023065.2   2.5
Histocompatibility 2, class II antigen A, beta 1 H2-Ab1 NM_207105.1   7.7
Histocompatibility 2, D region locus 1 H2-D1 NM_010380.2   3.0
Histocompatibility 2, class II, locus Dma H2-DMa NM_010386   3.9
Histocompatibility 2, class II, locus Mb1 H2-DMb1 NM_010387.2   5.8
Histocompatibility 2, class II, locus Mb2 H2-DMb2 NM_010388   5.5
Histocompatibility 2, class II antigen E alpha H2-Ea NM_010381.2   6.5
Histocompatibility 2, class II antigen E beta H2-Eb1 NM_010382.1   7.9
Histocompatibility 2, K1, K region H2-K1 NM_001001892.1   3.0
Histocompatibility 2, M region locus 3 H2-M3 NM_013819.1   2.6
Histocompatibility 2, Q region locus 2 H2-Q2 NM_010392.2   2.7
Histocompatibility 2, Q region locus 5 H2-Q5 NM_010393.1   2.9
Histocompatibility 2, T region locus 10 H2-T10 NM_010395.5   2.5
Histocompatibility 2, T region locus 23 H2-T23 NM_010398.1   2.9
Histocompatibility 2, T region locus 9 H2-T9 NM_010399   3.1
Peroxiredoxin 5 Prdx5 NM_012021   2.2
V Other ligand-mediated signalling     
Calcitonin/calcitonin-related polypeptide, alpha Calca NM_007587 2.0  
E2F transcription factor 2 E2f2 NM_177733.2 -3.4  
Endothelin 1 Edn1 NM_010104.2 2.1  
Endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 Edg5 NM_010333   2.1
FMS-like tyrosine kinase 1 Flt1 NM_010228.2 3.9  
Granulin Grn NM_008175.2   2.8
Mannose-6-phosphate receptor, cation dependent M6pr NM_010749.4   2.2
Paired-Ig-like receptor A1 Pira1 NM_011087.1 -2.1  
Paired-Ig-like receptor A11 Pira11 NM_011088.1 -2.1  
Paired-Ig-like receptor A3 Pira3 NM_011090.1 -3.8  
Paired-Ig-like receptor A4 Pira4 NM_011091.1 -2.4  
Peroxisome proliferator activated receptor gamma Pparg NM_011146.1 -2.7  
Pre-B-cell colony-enhancing factor 1 Pbef1 NM_021524.1   2.7
Secretoglobin, family 1A, member 1 (uteroglobin) Scgbla1 NM_011681.1 40.0  
Solute carrier family 1 (glial high affinity glutamate transporter), member 3 Slcla3 NM_148938.2 -2.5  
Spermine oxidase Smox NM_145533.1 -2.7  
Vascular endothelial growth factor A Vegfa NM_009505.2 2.5  
VI Complement-mediated     
Complement component 1, q subcomponent, alpha polypeptide C1qa NM_007572 -3.6  
Complement component 1, q subcomponent, beta polypeptide C1qb NM_009777.1 -4.5 3.8
Complement component 1, q subcomponent, C chain C1qg NM_007574.1 -4.3  
Complement component 2 (within H-2S) C2 NM_013484.1 -3.3  
Complement component 3 C3 NM_009778.1   4.2
Complement component 4A (Rodgers blood group) Slp NM_011413 2.3  
Complement component 6 C6 NM_016704.1 -2.6  
Complement factor B H2-Bf NM_008198.1 11.5 6.5
Complement factor properdin Pfc XM_135820.3 -10.3  
Four and a half LIM domains 1 Fhl1 NM_010211.1 2.3  
VII Apoptosis     
B-cell leukemia/lymphoma 2 related protein A1b Bcl2a1b NM_007534   2.5
B-cell leukemia/lymphoma 2 related protein A1d Bcl2a1d NM_007536   2.7
Caspase 1 Casp1 NM_009807.1   4.0
Caspase 4, apoptosis-related cysteine peptidase Casp4 NM_007609.1   2.4
Epithelial membrane protein 3 Emp3 NM_010129.1   2.3
Lectin, galactose binding, soluble 1 Lgals1 NM_008495.1   4.0
Thioredoxin 1 Txn1 NM_011660.3   2.1
VIII Signal transduction     
AXL receptor tyrosine kinase Axl NM_009465.2 -6.4  
C-mer proto-oncogene tyrosine kinase Mertk NM_008587 -3.7  
C-type lectin domain family 4, member a1 BC049354 XM_194289.2 -3.0  
C-type lectin domain family 4, member b1 Clec4b1 NM_027218.1 -3.9  
C-type lectin domain family 4, member a3 Clec4a3 NM_153197.3 -2.1  
CD63 antigen Cd63 NM_007653.1 3.3  
CD81 antigen Cd81 NM_133655.1 -4.6  
CD93 antigen C1qr1 NM_010740.1 3.7  
CD207 antigen Cd207 NM_144943.2 -2.2  
Chemokine (C-X-C motif) ligand 15 Cxcl15 NM_011339.1 5.0  
Colony stimulating factor 1 receptor Csf1r NM_007779.1 -9.5  
Integrin beta 5 Itgb5 NM_010580 -3.4  
Neutrophilic granule protein Ngp NM_008694.1 -8.9  
Plasminogen activator, urokinase Plau NM_008873.2 2.2  
S100 calcium binding protein A9 (calgranulin B) S100a9 NM_009114.1 -4.2  
Thrombomodulin Thbd NM_009378.1 4.6  
IX Other cell communication     
Cadherin 1 Cdh1 NM_009864.1 4.8 3.2
Hematological and neurological expressed sequence 1 Hn1 NM_008258.1   2.3
Intercellular adhesion molecule Icam1 NM_010493.2   2.3
Lectin, galactoside-binding, soluble, 3 binding protein Lgals3bp NM_011150.1   4.0
Proteolipid protein 2 Plp2 NM_019755.2   2.5
Purine-nucleoside phosphorylase Pnp NM_013632.2   3.2
X Natural killer cell-mediated immunity    
Fc fragment of IgG, low affinity IIIa, receptor Fcrl3 NM_144559.1   3.8
Killer cell lectin-like receptor subfamily C, member 1 Klrc1 NM_010652   3.8
Killer cell lectin-like receptor subfamily K, member 1 Klrk1 NM_033078.2   2.0
Natural killer cell group 7 sequence Nkg7 NM_024253.3   3.7
XI Other host immune responses     
Allograft inflammatory factor 1 Aif1 NM_019467.2 -2.8 2.7
ATP-binding cassette, sub-family C (CFTR/MRP), member 3 Abcc3 XM_358306.1 -10.6  
Carboxylesterase 3 Ces3 NM_053200.1 2.9  
Catalase Cat NM_009804.1 -2.3  
Cathelicidin antimicrobial peptide Camp NM_009921.1 -18.3  
Cathepsin E Ctse NM_007799 -2.3  
CD59a antigen Cd59a NM_007652.2 -3.0  
CD93 antigen C1qr1 NM_010740.1 3.7  
CD163 antigen Cd163 NM_053094.1 -10.1  
CD244 natural killer cell receptor 2B4 Cd244 NM_018729 -3.3  
Coagulation factor X F10 NM_007972.2 2.6  
Fc receptor, IgG, alpha chain transporter Fcgrt NM_010189.1 -4.8  
Glutathione peroxidase 1 Gpx1 NM_008160.1 -2.7  
Glutathione peroxidase 3 Gpx3 NM_008161.1 -2.0  
Glutathione S-transferase, mu 2 Gstm2 NM_008183.2 5.0  
Glutathione S-transferase omega 1 Gsto1 NM_010362.1 -2.1  
Guanine nucleotide binding protein (G protein), gamma 2 subunit Gng2 NM_010315.2   2.9
Guanine nucleotide binding protein (G protein), gamma 10 Gng10 NM_025277   2.4
Hemochromatosis Hfe NM_010424.2 -5.3  
Immunoresponsive gene 1 Irg1 XM_127883 2.8  
Interferon, alpha-inducible protein 27 2310061N23Rik NM_029803   3.9
Interferon induced transmembrane protein 2 Ifitm2 NM_030694.1 -2.0  
Interferon induced transmembrane protein 6 Ifitm6 XM_133956.3 -5.0  
Kruppel-like factor 6 Copeb NM_011803.1   2.5
Lipocalin 2 Lcn2 NM_008491.1 -5.1  
LPS-induced TN factor Litaf NM_019980   2.6
Lymphocyte antigen 96 Ly96 NM_016923.1 -2.2  
Lysozyme Lyzs NM_017372 2.5  
Mannose receptor, C type 1 Mrc1 NM_008625.1 -7.6  
Membrane-associated ring finger (C3HC4) 8 Mir NM_027920.3 -2.2  
Myeloperoxidase Mpo NM_010824.1 -3.3  
Peptidoglycan recognition protein 1 Pglyrp1 NM_009402.1 -2.5  
Peripheral myelin protein Pmp22 NM_008885.1 3.5  
Peroxidasin homolog (Drosophila) 2310075M15Rik XM_283052 2.0  
Peroxiredoxin 2 Prdx2 NM_011563.2 -3.5  
Peroxiredoxin 5 Prdx5 NM_012021   2.4
Phytoceramidase, alkaline Phca NM_025408.1 -2.1  
Prosaposin Psap NM_011179 -2.1 2.3
Regulator of G-protein signaling 1 Rgs1 NM_016846.2   4.8
S100 calcium binding protein A4 S100a4 NM_011311.1   4.6
S100 calcium binding protein A8 (calgranulin A) S100a8 NM_013650.1 -4.4  
SAM domain and HD domain, 1 Samhd1 BC067198   2.8
Selenoprotein P, plasma, 1 Sepp1 NM_009155.3 -2.4  
Serum amyloid A 3 Saa3 NM_011315 4.5  
Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 Slc11a1 NM_013612.1 -2.2  
Superoxide dismutase 2, mitochondrial Sod2 NM_013671.2   2.9
Surfactant associated protein A1 Sftpa1 NM_023134.3 2.5  
Surfactant associated protein D Sftpd NM_009160.1 10.4  
XII Genes mentioned in text but not categorized by Panther   
Chemokine (C-X-C motif) ligand 12 Cxcl12 NM_013655.2 4.0  
Chemokine (C-X-C motif) ligand 13 Cxcl13 NM_018866.1 2.1  
Chemokine (C-X-C motif) ligand 16 Cxcl16 NM_023158   4.1
Expressed sequence AA467197 AA467197 NM_001004174.1   8.8
Lymphocyte antigen 6 complex, locus A Ly6a NM_010738.2 5.8 4.7
Immunity-related GTPase family, M Irgm NM_008326.1   2.8
Lymphocyte antigen 6 complex, locus C Ly6c NM_010741   3.0
Mus musculus lactotransferrin Ltf NM_08522.2 -16.8  
Proteasome (prosome, macropain) subunit, beta type 9 Psmb9 NM_013585.1   2.9
Proteasome (prosome, macropain) subunit, beta type 8 Psmb8 NM_010724   3.2
Proteasome (prosome, macropain) subunit, beta type 10 Psmb10 NM_013640.1   2.4
Serine (or cysteine) peptidase inhibitor, clade A, member 3G Serpina3g NM_009251.1   14.8
Three prime repair exonuclease 1 Trex1 NM_011637.4   2.0
Tryptophanyl-tRNA synthetase Wars NM_011710.2   2.2
Tumor necrosis factor (ligand) superfamily, member 13b Tnfsf13b NM_033622 3.1 3.0
Ubiquitin D (Ubd) Ubd NM_023137.2   4.2
Ubiquitin specific peptidase 18 Usp18 NM_011909.1   2.6
  1. Expression was analyzed using Genome Studio and classified by immune function through Panther Immune Processes. Genes not classified by Panther but clearly related to immune processes were added manually (section XII). All processes were analyzed statistically with a p-value ≤ 0.05.