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Table 3 Enriched functions of 1,026 ROS-diabetes targets

From: Literature-based discovery of diabetes- and ROS-related targets

Category

Term

#target

p-value

Fold

Biological Processes GO

metabolic process

113

3.40E-26

3.3

 

protein amino acid phosphorylation

98

2.90E-24

3.5

 

response to hypoxia

36

8.80E-24

12

Molecular Functions GO

protein binding

514

2.80E-71

2.1

 

oxidoreductase activity

103

1.50E-31

4.2

 

transferase activity

148

1.70E-26

2.7

Cellular Components GO

cytoplasm

381

1.50E-57

2.3

 

extracellular region

220

9.10E-44

2.9

 

mitochondrion

154

6.30E-43

3.9

Pathway

Focal adhesion

75

2.40E-42

9.4

 

Apoptosis

49

6.70E-35

14.5

 

MAPK signaling pathway

73

4.30E-34

6.9

  1. '#target' refers to the number of ROS-diabetes targets with each biological function with Benjamini-Hochberg adjusted p-values. Fold is the ratio of targets from the ROS-diabetes set to the complete HUGO gene set.