Figure 2

Summary of the enrichments found in childhood ALL and AML when analyzed against gene sets derived from a large set of normal hematopoietic cells, normal tissues and different types of human cancers using GSEA. Only enrichments found among the upregulated genes in the various leukemia subtypes and the different gene sets are shown. A-C depict enrichments found in ALL and D-F in AML. A red colored square indicate a significant enrichment among genes being upregulated in a genetic subtype with genes contained within a gene set being upregulated in a specific tissue. A green colored square indicates a significant enrichment among genes being upregulated in a genetic subtype with genes contained within a gene set that is downregulated in a specific tissue. The number in the squares shows the normalized enrichment score, which can be used to compare the results across gene sets. Only scores for significant enrichments as determined by FDR are shown in the figure. A and D) genes contained in genes sets from normal flow sorted hematopoietic cells. Also included, as positive controls, are gene sets from previously generated gene expression data of pediatric ALL, B and E) genes contained in genes sets from a large set of different normal human tissues, and C and F) genes contained in genes sets from different human cancers.