Figure 1

Microarray gene expression profile of subcutaneous adipose tissues. A) Hierarchical clustering analysis of the gene expression profiles of the subcutaneous adipose tissues of 15 morbidly obese patients. The results are represented as log₂ ratios. Increasing red intensity denotes increased gene expression and increasing green intensity denotes decreased gene expression according to the scale bar at the top of the figure. The genes are grouped according to the similarity of their expression patterns using Euclidean distances and the average linkage clustering method. B) Upregulated and downregulated gene expression in the adipose tissues of morbidly obese subjects. The bars represent the mean gene expression ± SE determined with the microarray (n = 15). Grey areas represent the genes with average gene expression over or below the cut-off log₂ ratio value of 0.8 or -0.8, respectively.