Animal model integration to AutDB, a genetic database for autism

BMC Medical Genomics

Table 1 PhenoBase.

Category ID	PhenoBase Category	Relationship to Autism	Relevance to Autism
1	General observations
2	Social behavior	Core behavioral phenotype: Social interactions	DSM IV diagnostic criteria
3	Communications	Core behavioral phenotype: Communications	DSM IV diagnostic criteria
4	Repetitive behavior	Core behavioral phenotype: Restricted interests & Repetitive behavior	DSM IV diagnostic criteria
5	Maternal behavior	Broader phenotype of social memory, affect & attachment
6	Motor phenotype	Auxiliary phenotype of ASD	Turner et al., 2001 [24]
7	Sensory	Auxiliary phenotype of ASD	Geyer and Swedlow, 1998 [25]
8	Learning & memory	Auxiliary phenotype of ASD
9	Emotion	Hypothesis: Dysfunction of amygdala	Tsai, 1999 [26]
10	Seizure	25% cases	Ballaban-Gil and Tuchman, 2000 [27]
11	Circadian sleep/wake cycle	Auxiliary phenotype: sleep disturbances	Harvey and Kennedy, 2002 [28]
12	Homeostasis	Unresolved
13	Inflammatory response	Auxiliary phenotype of ASD
14	Synaptic function	Hypothesis: Imbalance in E/I ratio
15	Neuroanatomy/Ultra- structure/Cytoarchitecture	Macrocephaly	Piven et al., 1992 [29]
16	Molecular profile	Unresolved

Table depicting the 16 categories of PhenoBase, along with their relationships and relevance to autism.

ISSN: 1755-8794