Skip to main content

Table 2 Enriched biological processes of miRNA and miRNA* target genes.

From: Integrative analysis of next generation sequencing for small non-coding RNAs and transcriptional regulation in Myelodysplastic Syndromes

biological processes (pval) Cell Death
(1.84E-06)
Cellular Development (3.93E-06) Gene Expression
(8.34E-06)
Cell Cycle
(1.05E-04)
Cellular Function and Maintenance
(1.05E-04)
involved genes ACVR2B,BACH2 (includes EG:60468), CCDC6, E2F3, EGR3, HMGA2, IGF1, IGF1R,IKZF2, IRS2, MECP2, MIB1, NLK, NOVA1 CCDC6, CHD7, CNOT6L, DYRK1A, E2F3, EGR3, ESRRG, FNDC3A, HMGA2, IGF1, IGF1R, IGF2BP1, IRS2, MECP2, MIB1, MLL2, NLK, ONECUT2 ACVR2B, ATXN1, BACH2 (includes EG:60468), BAZ2A, BRWD1, CEP350, E2F3, EGR3, ESRRG, HMGA2, IGF1, IGF2BP1, JARID2, KLF12, MECP2, NFAT5, NFIB, NLK, ONECUT2 E2F3, ESRRG, IGF1, IGF1R, IRS2, JARID2 CLCN5, EGR3, IGF1, IGF1R, IRS2
selected genes (miRNA) ACVR2B (↑),ADAMTS6 (↑),ANKRD52 (↓),ARPP-19 (N/A),ATXN1 (↑),BACH2 (↑),BAZ2A ( ),BRWD1 ( ),CCDC6 (↑),CEP350 ( ),CHD7 (N/A),CLCN5 (↑),CNOT6L ( ),CPD ( ),CPEB2 ( ),CPEB3 (↑),CPEB4 (↓),CSNK1G1 (↑),DCBLD2 ( ),DYRK1A ( ),E2F3 (↓),EGR3 (↓),EIF2C1 (↑),ESRRG ( ),ETNK1 (↓),FIGN ( ),FNDC3A ( ),GLT8D3 (↓),HIC2 (↑),HMGA2 (↓),IGF1 ( ),IGF1R (↓),IGF2BP1 (↑),IKZF2 (↓),IRS2 ( ),ITGB8 (↑),JARID2 (↓),JHDM1 D (N/A),KLF12 (↑),LIN28 (↑),LIN28B (↑),MECP2 ( ),MIB1 (↑),MIER3 (↓),MLL2 (↓),NFAT5 ( ),NFIB (↑),NLK (↓),NOVA1 (↑),NRK (↑),ONECUT2 (↑),OTUD4 (↓),PALM2 (↑),PAPD5 ( ),PBX3 (↓),PGM2L1 (↑),PLAG1 ( ),PLAGL2 ( ),PTPRD (↑),PURB (↓),QKI ( ),RNF165 (↑),RNF38 ( ),RPS6KA3 (↓),SNX16 (↑),SOCS6 (↓),SP1 ( ),SRGAP3 (↑),TBL1XR1 (↓),TGFBR1 ( ),TMCC1 (↑),TNRC6B (↓),ZBTB34 ( ),ZFHX4 (↑)
biological processes (pval) Gene Expression
(2.02E-09)
Cell Cycle
(3.12E-05)
RNA Post-Transcriptional Modification
(3.14E-05)
Cell Death
(3.43E-05)
Cellular Development
(5.40E-05)
involved genes ACVR2B, BACH2 (includes EG:60468), BCL11B, BMPR2, CBL, CREBZF, CTDSP2, DDX6, ESRRG, FGF7, FOXN3, HIPK2, HLF (includes EG:3131), IGF1, KLF12, MAF, MECP2, MEF2 D, MTF1, NFAT5, NFIB, ONECUT2, PBX1, PURB, SMAD4, SOX11, SP1, TEAD1, THRB, TRPS1, ZNF148 CBL, DCX, ESRRG, FGF7, FOXN3, IGF1, IGF1R, RPS6KA3, SMAD4, SP1, THRB CNOT6L, CUGBP2, MBNL1, NOVA1, SFRS1 ACVR2B, BACH2 (includes EG:60468), BCL11B, BMPR2, CBL, CREBZF, CTDSP2, DDX6, ESRRG, FGF7, FOXN3, HIPK2, HLF (includes EG:3131), IGF1, KLF12, MAF, MECP2, MEF2 D, MTF1, NFAT5, NFIB, ONECUT2, PBX1, PURB, SMAD4, SOX11, SP1, TEAD1, THRB, TRPS1, ZNF148 ACVR2B, BCL11A, BCL11B, BMPR2, CBL, CNOT6L, COL11A1, DCX, DYRK1A, ESRRG, FGF7, HIPK2, IGF1, IGF1R, KCNMA1, MAF, MARCKS (includes EG:4082), MBNL1, MECP2, MEF2 D, MLL2, NDST1, ONECUT2, PBX1, PLAG1, RC3H1, SMAD4, SP1, THRB, ZFX
selected genes (miRNA*) AAK1 (↓),ACVR2B (↑),ADCY1 (↑),AFF2 (↓),ANKS1B (↑),ARHGEF12 ( ),BACH2 (↑),BCL11A (↑),BCL11B (↓),BMPR2 (↑),BNC2 (↑),BSN ( ),C1orf21 (↑),CBL ( ),CNOT6L ( ),COL11A1 (↑),CPEB2 ( ),CREBZF (↓),CTDSP2 (↓),CUGBP2 ( ),DCX (↑),DDX6 ( ),DYRK1A ( ),ENAH (↑),ESRRG ( ),FGF7 (↑),FLJ20309 (N/A),FOXJ3 (↓),FOXN3 (↓),GATAD2B ( ),HELZ ( ),HIPK2 (↓),HLF (↑),HNRNPU (↓),IGF1 ( ),IGF1R (↓),IKZF2 (↓),JHDM1 D (N/A),KCMF1 ( ),KCNMA1 (↑),KLF12 (↑),LPHN2 (↑),MAF (↑),MAPK1IP1L ( ),MARCKS ( ),MBNL1 (↓),MECP2 ( ),MEF2 D (↓),MEX3A (N/A),MLL2 (↓),MTF1 (N/A),MYT1L (↑),NAV1 (↑),NDST1 (↑),NFAT5 ( ),NFIB (↑),NOVA1 (↑),NUFIP2 ( ),ONECUT2 (↑),PBX1 (↑),PHF15 (↑),PLAG1 ( ),PTPRD (↑),PURB (↓),RC3H1 (N/A),RIC8B (↑),RPS6KA3 (↓),SAMD12 (↑),SERBP1 (↑),SFRS1 ( ),SHANK2 (↑),SLC5A3 (↓),SMAD4 ( ),SMG1 (↑),SOX11 (↑),SP1 ( ),SPOPL ( ),STXBP5L (N/A),TEAD1 (↑),THRB (↑),THSD7B (N/A),TMEM170B (N/A),TNRC6B (↓),TRPS1 (↓),UBL3 ( ),ZC3H12C (N/A),ZCCHC24 (↑),ZFAND5 ( ),ZFHX4 (↑),ZFX ( ),ZNF148 (↓),ZNF609 (N/A),tcag7.1228 (N/A),
  1. This tables gives an overview of the selected miRNA (top) and miRNA* (bottom) target genes, their regulation (bold is used for significant expression and italic for non-significant expression), the top five molecular functions of these genes as well as the genes involved in these functions.