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Table 1 The identified significant proteins in lung carcinogenesis

From: A network-based biomarker approach for molecular investigation and diagnosis of lung cancer

Protein symbol CRV p-value Functional annotation* Literature evidence§
    Cell growth Cell survival Cell migration  
MAPK1 8.3418 < 1e-5 + + + [31, 32]
SMAD2 7.7901 < 1e-5 + + + [36]
CREBBP 5.7870 0.00002 +    [44]
EGFR 4.3635 0.00086 + + + [3941]
AR 4.0966 0.00159 + + + [49]
UBC 4.0331 0.00180     
SRC 3.9446 0.00218 + + + [51, 63]
FGFR1 3.9227 0.00237 +   + [42]
BRCA1 3.9049 0.00243 + +   [58]
ESR1 3.8409 0.00295 + + + [50]
INSR 3.7946 0.00329 +   + [43]
PTK2 3.6758 0.00432 + + + [63, 64]
HSP90AA1 3.6732 0.00436 + + + [54]
CALM1 3.6363 0.00482   +   
POLR2A 3.5701 0.00547     
CSNK2A1 3.4128 0.00761 + +   [61]
PRKACA 3.3688 0.00856   +   
CTNNB1 3.2935 0.00994 + + + [45]
SP1 3.2397 0.01133 + +   [59]
SMAD4 3.1947 0.01266 + + + [36]
E2F1 3.1382 0.01407 + +   [46]
YWHAZ 3.1212 0.01467 +    [52]
MEPCE 3.0968 0.01545     
AKT1 3.0193 0.01857 + + + [62]
PLCG1 2.9654 0.02069    + [66]
MYC 2.8987 0.02385 + +   [47]
MAPK3 2.8545 0.02654 + + + [31, 32]
NCOA6 2.8132 0.02892 + +   
FYN 2.7833 0.03089 +   + [48]
MAPK8IP3 2.7746 0.03141    +  
YWHAQ 2.7582 0.03242 +    [53]
TRAF6 2.7150 0.03535   +   [57]
SMAD1 2.6940 0.03697 + + + [37]
SMAD3 2.6815 0.03815 + + + [36]
MAPK14 2.6727 0.03894 + + + [34]
TP53 2.6522 0.04056 + + + [40, 41, 55]
XRCC6 2.6270 0.04263   +   
EZR 2.6213 0.04314    + [67]
TSC2 2.6116 0.04401 + + + [65]
HGS 2.5730 0.04744 +    
  1. The full names of these proteins according to UniProt database http://www.uniprot.org/ are listed in Additional file 2.
  2. * The functional annotations are from the Gene Ontology database http://www.geneontology.org/ and literatures.
  3. § The literature evidences indicate that overexpression/dysregulation of the specific protein or mutation of the corresponding gene would result in carcinogenesis.