An integrative approach to identifying cancer chemoresistance-associated pathways

BMC Medical Genomics

Table 3 Genes identified in figure 3 with p-value < 0.05 by t-test

Gene Symbol	Ovarian p-value	Betweenness (mean = 3.8E-4)	Degree (mean = 9.71E-4)	Connected nodes
c-KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, also called KIT or C-kit receptor)	3.53E-07	0.00178	0.006483
GRB2 (growth factor receptor-bound protein 2)	5.74E-06	0.020155	0.023064	V
AKT2 (v-akt murine thymoma viral oncogene homolog 2)	0.022784	3.89E-04	0.002369	V
PIK3CG (phosphoinositide-3-kinase, catalytic, gamma polypeptide)	1.29E-04	9.77E-05	0.001247

Genes listed in this table are significant in ovarian expression data with p-value < 0.05. Moreover, the betweenness and degree centrality of each gene are also listed. Both GRB2 and AKT2 gene are connected nodes; which indicates they pass down signals between pathways. GRB2 with significant betweenness and degree centrality indicates it has potential to act as a "hub node" in biological interaction networks and to involve in chemoresistant mechanisms as well.

ISSN: 1755-8794