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Table 3 Genes identified in figure 3 with p-value < 0.05 by t-test

From: An integrative approach to identifying cancer chemoresistance-associated pathways

Gene Symbol Ovarian p-value Betweenness
(mean = 3.8E-4)
Degree
(mean = 9.71E-4)
Connected nodes
c-KIT
(v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, also called KIT or C-kit receptor)
3.53E-07 0.00178 0.006483  
GRB2
(growth factor receptor-bound protein 2)
5.74E-06 0.020155 0.023064 V
AKT2
(v-akt murine thymoma viral oncogene homolog 2)
0.022784 3.89E-04 0.002369 V
PIK3CG
(phosphoinositide-3-kinase, catalytic, gamma polypeptide)
1.29E-04 9.77E-05 0.001247  
  1. Genes listed in this table are significant in ovarian expression data with p-value < 0.05. Moreover, the betweenness and degree centrality of each gene are also listed. Both GRB2 and AKT2 gene are connected nodes; which indicates they pass down signals between pathways. GRB2 with significant betweenness and degree centrality indicates it has potential to act as a "hub node" in biological interaction networks and to involve in chemoresistant mechanisms as well.