Figure 4

Immunological components of normal tissue. (A) Heatmap of the immunological gene expression fold-change comparisons among the 79 tissues from the SymAtlas [24]. This matrix displays the average immune score from those genes that contribute to greater than 2 times fold change difference between each tissue's pairwise comparisons. This combination of expression profiling and immunological grading detects a heterogeneous difference in the immunological components between tissues in a global manner. Both the X and Y-axis are numerical index of the 79 tissues (the mapping of this index to tissue name is listed in Additional File 8). With respect to the robustness of immune genes in the interactome : (B) Tissue specific interactome networks for Wholeblood (eccentricity centrality = 0.67) and Heart (eccentricity centrality = 0.72). The difference in the average eccentricity value is only marginally visible by eye as evidenced by a lower symmetry of the Heart network (the same transparent circle drawn on top of the two networks displayed by means of the same algorithm using the software yEd).