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Table 2 Genes found in altered modules of head and neck squamous cell carcinoma (HNSCC).

From: Functional microarray analysis suggests repressed cell-cell signaling and cell survival-related modules inhibit progression of head and neck squamous cell carcinoma

Module Status Gene symbol p-value
Negative lymph node (20 samples)    
Protein biding repressed FOSB 4.1E-31
   KLK6 5.7E-18
   AREG 1.3E-11
   CCL20 4.0E-08
   IL1B 7.5E-05
   MYC 2.0E-04
   INHBA 7.0E-03
   EGFR 1.4E-02
   AKT1 2.1E-02
Regulation of apoptosis repressed SPHK1 9.0E-09
   INHBA 9.0E-09
   AKT1 9.7E-03
KLK pathway induced KLK13 4.0E-15
   KLK7 2.8E-05
   KLK6 1.5E-02
   SERPINA3 1.7E-02
Positive lymph node (61 samples)    
KLK pathway repressed KLK13 4.0E-15
   KLK7 2.8E-05
   KLK6 1.5E-02
   SERPINA3 1.7E-02
Recurrent tumors (20 samples)    
Cell-cell signaling induced IL1F9 4.1E-20
   AREG 5.5E-15
   INHBA 1.5E-12
   BST2 7.6E-10
   CCL20 2.1E-3
   KLK6 8.9E-3
Non-recurrent tumor (27samples)    
Cell-cell signaling repressed IL1F9 4.1E-20
   AREG 5.5E-15
   INHBA 1.5E-12
   BST2 7.6E-10
   CCL20 2.1E-3
   KLK6 8.9E-3
Extracellular region repressed INHBA 6.6E-15
   POSTN 3.0E-9
   KLK13 1.9E-6
   AREG 2.4E-6
   MMP13 7.3E-4
   KLK6 1.6E-2
  1. HNSCC patients were classified according to pathologic lymph node status (positive or negative) or tumor recurrence (recurrent or non-recurrent tumor) after treatment (surgery with neck dissection followed by radiotherapy) and samples from primary tumors were collected. Gene expression was assessed by microarray and functional module analysis was performed. Functional modules were defined according to the following databases: Biocarta], GeneDecks, Gene Ontology, and to the Kyoto Encyclopedia of Genes and Genomes Pathway Database (KEGGPD).