Table 2 Genes found in altered modules of head and neck squamous cell carcinoma (HNSCC).
Module | Status | Gene symbol | p-value |
|---|---|---|---|
Negative lymph node (20 samples) | |||
Protein biding | repressed | FOSB | 4.1E-31 |
KLK6 | 5.7E-18 | ||
AREG | 1.3E-11 | ||
CCL20 | 4.0E-08 | ||
IL1B | 7.5E-05 | ||
MYC | 2.0E-04 | ||
INHBA | 7.0E-03 | ||
EGFR | 1.4E-02 | ||
AKT1 | 2.1E-02 | ||
Regulation of apoptosis | repressed | SPHK1 | 9.0E-09 |
INHBA | 9.0E-09 | ||
AKT1 | 9.7E-03 | ||
KLK pathway | induced | KLK13 | 4.0E-15 |
KLK7 | 2.8E-05 | ||
KLK6 | 1.5E-02 | ||
SERPINA3 | 1.7E-02 | ||
Positive lymph node (61 samples) | |||
KLK pathway | repressed | KLK13 | 4.0E-15 |
KLK7 | 2.8E-05 | ||
KLK6 | 1.5E-02 | ||
SERPINA3 | 1.7E-02 | ||
Recurrent tumors (20 samples) | |||
Cell-cell signaling | induced | IL1F9 | 4.1E-20 |
AREG | 5.5E-15 | ||
INHBA | 1.5E-12 | ||
BST2 | 7.6E-10 | ||
CCL20 | 2.1E-3 | ||
KLK6 | 8.9E-3 | ||
Non-recurrent tumor (27samples) | |||
Cell-cell signaling | repressed | IL1F9 | 4.1E-20 |
AREG | 5.5E-15 | ||
INHBA | 1.5E-12 | ||
BST2 | 7.6E-10 | ||
CCL20 | 2.1E-3 | ||
KLK6 | 8.9E-3 | ||
Extracellular region | repressed | INHBA | 6.6E-15 |
POSTN | 3.0E-9 | ||
KLK13 | 1.9E-6 | ||
AREG | 2.4E-6 | ||
MMP13 | 7.3E-4 | ||
KLK6 | 1.6E-2 |